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Huo Guang-Hua Cui Chao-Yu He Tian Yan Jun-Qing Peng Wen-Wen 《Chemistry of Natural Compounds》2022,58(3):468-470
Chemistry of Natural Compounds - A new carotane sesquiterpenoid, methyl gymnabloate (1), was isolated from the fermentation broth of the wild macrofungus Gymnopus sp. 0612-9. Its structure was... 相似文献
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Wen-Wen Zhao Ke Zan Jing-Yue Wu Wei Gao Jie Yang Yin-Ying Ba 《Natural product research》2019,33(17):2435-2439
One new triterpenoid (1) and seven known analogues (2–8) were isolated from the leaves of Ilex hainanensis Merr.. Their structures were established by analysis of their MS, 1D and 2D NMR spectroscopic data and comparison with those in the literature. The antibacterial activity of compounds 1–8 were evaluated by determination of minimum inhibitory concentration using twofold microdilution broth method against Streptococcus mutans ATCC 25175 (Gram-positive) and Fusobacterium nucleatum ATCC 10953 (Gram-negative). Compounds 3 and 5 showed significant antibacterial activity against S. mutans in concentration of 9.7 μg/mL, while showed little antibacterial activity against F. nucleatum. On the contrary, the inhibitory activity of compounds 1, 2 and 6 against F. nucleatum were higher than them against S. mutans. 相似文献
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Wen-Wen Zhang Prof. Dr. Bi-Jie Li 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2023,135(1):e202214534
Despite the advances in the area of catalytic alkene hydrosilylation, the enantioselective hydrosilylation of alkenes bearing a heteroatom substituent is scarce. Here we report a rhodium-catalyzed hydrosilylation of β,β-disubstituted enamides to directly afford valuable α-aminosilanes in a highly regio-, diastereo-, and enantioselective manner. Stereodivergent synthesis could be achieved by regulating substrate geometry and ligand configuration to generate all the possible stereoisomers in high enantio-purity. 相似文献
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Hong-Jing YU Wen-Wen XIA Li-Guo SONG Yang DING Yu HAO Li-Qiang KANG Xin-Xiang PAN Li YAO 《物理化学学报》2017,33(11):2207-2218
In this work, the harmonic and anharmonic rate constants of the decomposition reaction of monomethylhydrazine (MMH) radicals have been calculated by using transition state (TS) and Rice-Ramsperger-Kassel-Marcus (RRKM) theories with either MP2 or B3LYP method at 6-311++G (3df, 2p) basis set, respectively. The reaction mechanism and anharmonic effect of the MMH radicals are studied in detail and both of the harmonic and anharmonic rate constants increase sharply with increasing temperature in the canonical system. In the microcanonical system, these constants also show sharp increase with the energies. Overall, the anharmonic effect becomes more pronounced with the increasing temperature or energy in the canonical and microcanonical systems, respectively. These results indicate that the anharmonic effect of the decomposition reaction of MMH radicals is quite significant and cannot be ignored. 相似文献
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Jun-Jie Shi Qi-Hui Jiang Tian-Ning Zhang Hao Sun Wen-Wen Shi Hendra Gunosewoyo Fan Yang Jie Tang Tao Pang Li-Fang Yu 《Molecules (Basel, Switzerland)》2021,26(5)
Sigma-1 (σ-1) receptor agonists are considered as potential treatment for stroke. TS-157 is an alkoxyisoxazole-based σ-1 receptor agonist previously discovered in our group. The present study describes TS-157 profile in a battery of tests for cerebral ischemia. Initial evaluation demonstrated the compound’s safety profile and blood–brain barrier permeability, as well as its ability to induce neurite outgrowth in vitro. The neurite outgrowth was shown to be mediated via σ-1 receptor agonism and involves upregulation of ERK phosphorylation (pERK). In particular, TS-157 also significantly accelerated the recovery of motor function in rats with transient middle cerebral artery occlusion (tMCAO). Overall, the results herein support the notion that σ-1 receptor agonists are potential therapeutics for stroke and further animal efficacy studies are warranted. 相似文献
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A microwave-assisted base-free intramolecular cross dehydrogenative coupling (CDC) of 3-aniline substituted coumarins and quinolinones have been developed. A broad range of indolo[2,3-c]coumarins and indolo[2,3-c]quinolinones can be easily afforded in good to high yields (up to 93%) under palladium catalysis. The method is among the most straightforward and convenient ways to access these fused polyheterocycles. 相似文献
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Liu Wen-Wen Yang Zi-Feng Fei Shao-Ming 《International Journal of Theoretical Physics》2021,60(11-12):4177-4195
International Journal of Theoretical Physics - We investigate the monogamy relations related to the concurrence, the entanglement of formation, convex-roof extended negativity, Tsallis-q... 相似文献
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Wen-Wen Zi Zihao Gao Prof. Jun Zhang Bao-Xun Zhao Xian-Shu Cai Prof. Hong-Bin Du Prof. Fei-Jian Chen 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(10):3976-3979
Extra-large-pore zeolites for processing large molecules have long been sought after by both the academia and industry. However, the synthesis of these materials, particularly extra-large-pore pure silica zeolites, remains a big challenge. Herein we report the synthesis of a new extra-large-pore silica zeolite, designated NUD-6, by using an easily synthesized aromatic organic cation as structure-directing agent. NUD-6 possesses an intersecting 16×8×8-membered ring pore channel system constructed by four-connected (Q4) and unusual three-connected (Q3) silicon species. The organic cations in NUD-6 can be removed in nitric acid to yield a porous material with high surface area and pore volume. The synthesis of NUD-6 presents a feasible means to prepare extra-large pore silica zeolites by using assembled aromatic organic cations as structure-directing agents. 相似文献