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1.
A new organic reference material,l‐glutamic acid,USGS41a,for δ13C and δ15N measurements − a replacement for USGS41 下载免费PDF全文
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Stanley E. Ukwueze Patience O. Osadebe Festus B.C. Okoye 《Natural product research》2015,29(18):1728-1734
Bioactivity-guided fractionation of methanol extract from the leaves of Psidium guajava L. (Myrtaceae) yielded a new benzophenone glycoside, Guajaphenone A (2) together with two known compounds, Garcimangosone D (1) and Guaijaverin (3). Their structures were elucidated by analysis of spectroscopic data including 1D and 2D NMR and electrospray ionisation mass spectrometry (ESI-MS). The isolated compounds were screened against standard strains of Gram-positive and Gram-negative bacteria using broth dilution assay method, and the MIC values determined and compared with reference antibiotic ceftriaxone. They were found to have significant antibacterial activities against Escherichia coli and Staphylococcus aureus with all of them showing better activities against S. aureus, but displaying weaker activities, in comparison to ceftriaxone. However, despite reduced effect of these compounds against the organisms, this work opens the perspective to use these molecules as ‘leads’ for the design of novel and selective drug candidates for some tropical infectious diseases. 相似文献
3.
Inversion twinning in a second polymorph of the hydrochloride salt of the recreational drug ethylone
T. Stanley Cameron J. Stuart Grossert Chad R. Maheux Idralyn Q. Alarcon Catherine R. Copeland Anthony Linden 《Acta Crystallographica. Section C, Structural Chemistry》2015,71(4):266-270
A second polymorph of the hydrochloride salt of the recreational drug ethylone, C12H16NO3+·Cl−, is reported [systematic name: (±)‐2‐ethylammonio‐1‐(3,4‐methylenedioxyphenyl)propane‐1‐one chloride]. This polymorph, denoted form (A), appears in crystallizations performed above 308 K. The originally reported form (B) [Wood et al. (2015). Acta Cryst. C 71 , 32–38] crystallizes preferentially at room temperature. The conformations of the cations in the two forms differ by a 180° rotation about the C—C bond linking the side chain to the aromatic ring. Hydrogen bonding links the cations and anions in both forms into similar extended chains in which any one chain contains only a single enantiomer of the chiral cation, but the packing of the ions is different. In form (A), the aromatic rings of adjacent chains interleave, but pack equally well if neighbouring chains contain the same or opposite enantiomorph of the cation. The consequence of this is then near perfect inversion twinning in the structure. In form (B), neighbouring chains are always inverted, leading to a centrosymmetric space group. The question as to why the polymorphs crystallize at slightly different temperatures has been examined by density functional theory (DFT) and lattice energy calculations and a consideration of packing compactness. The free energy (ΔG) of the crystal lattice for polymorph (A) lies some 52 kJ mol−1 above that of polymorph (B). 相似文献
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In this paper we address the existence of smooth manifolds proper homotopy equivalent to nonuniform arithmetic manifolds M = Γ\G/K that are not homeomorphic to it. While the manifolds M are properly rigid if rankℚ(Γ) ≤ 2, we show that the so‐called virtual structure group has infinite rank as a ℚ‐vector space if rankℚ(Γ) ≥ 4.© 2015 Wiley Periodicals, Inc. 相似文献
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A variety of cephalosporins have been converted into the corresponding 2-alkoxy derivatives using ceric ammonium nitrate in the appropriate alcohol. 相似文献
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Nicholas Douglas Charles J. Neef Robert A. Rogers Jake A. Stanley Jacob Armitage Ben Martin Todd W. Hudnall William J. Brittain 《Journal of Physical Organic Chemistry》2013,26(8):688-695
The synthesis and reactivity of a tetrahydrochromeno[2,3‐b]indoles are reported. Evidence for reversible ring‐opening is based on H/D exchange and trapping experiments. These compounds readily undergo reaction with tetra‐n‐butylammonium cyanide. The cyanide reaction is 10–100× faster when the solution is irradiated with 350 nm light. Reaction with trimethylsilyl cyanide occurs only with UV irradiation demonstrating photoreactivity. The rate of tetrahydrochromeno[2,3‐b]indole ring‐opening is greater for (i) Me substitution at the hemiaminal carbon (compared to Ph), and (ii) substitution of fluorine at the 9‐position of the indole. Under acidic conditions, the ring‐opened indolium ion is observed. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
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Morphine fluorescence spectra were obtained for morphine sulfate in distilled water, in KRP solution, and in KRP solutions with various concentrations of Ca++ and Mg++. No evidence of fluorescence shifting indicative of complex formation was observed. Similar solutions were used in a potentiometric study, and no evidence for complex formation was observed. 相似文献