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A Study of Possible Morphine Complexes Formed with Calcium and Magnesium
Authors:Leon L Combs  Charles Waggoner  Stanley K Burt  Gary Dukes
Institution:1. Department of Chemistry , Mississippi State University , Mississippi State, MS, 39762;2. Department of Pharmacology and Toxicology , University Medical Center , Jackson, Mississippi, 39216;3. Department of Genetic , Stanford Universityk Medical Center , Standford, California , 94305;4. Department of Chemistry , University of Alabama University , Alabama, 35486
Abstract:Morphine fluorescence spectra were obtained for morphine sulfate in distilled water, in KRP solution, and in KRP solutions with various concentrations of Ca++ and Mg++. No evidence of fluorescence shifting indicative of complex formation was observed. Similar solutions were used in a potentiometric study, and no evidence for complex formation was observed.
Keywords:Morphine  Ca++  Mg++  Complexes  Fluorescence  Potentiometric Titration
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