In this study, manganese tellurite (MnTeO
3) nanoparticles are developed as theranostic agents for magnetic resonance imaging (MRI)-guided photothermal therapy of tumor. MnTeO
3 nanoparticles are synthesized via a simple one-step method. The as-synthesized MnTeO
3 nanoparticles with uniform size show good biocompatibility. In particular, MnTeO
3 nanoparticles exhibit a high photothermal conversion efficiency (η = 26.3%), which is higher than that of gold nanorods. Moreover, MnTeO
3 nanoparticles also have high MRI performance. The longitudinal relaxivity (
r1) value of MnTeO
3 nanoparticles is determined to be 8.08 ± 0.2 mm
−1 s
−1, which is higher than that of clinically approved
T1-contrast agents Gd-DTPA (4.49 ± 0.1 mm
−1 s
−1). The subsequent MnTeO
3 nanoparticles-mediated photothermal therapy displays a highly efficient ablation of tumor cells both in vitro and in vivo with negligible toxicity. It is demonstrated that MnTeO
3 nanoparticles can serve as promising theranostic agents with great potentials for MRI-guided photothermal therapy.
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