Facile Synthesis of Manganese Tellurite Nanoparticles for Magnetic Resonance Imaging-Guided Photothermal Therapy |
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| Authors: | Yu He Yating Guo Yanbin Yu Peifu Luo Honglong Qiu Guoming Huang |
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| Institution: | 1. MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, 350116 P. R. China;2. College of Environment and Resources, Fuzhou University, Fuzhou, 350116 P. R. China;3. College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116 P. R. China |
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| Abstract: | In this study, manganese tellurite (MnTeO3) nanoparticles are developed as theranostic agents for magnetic resonance imaging (MRI)-guided photothermal therapy of tumor. MnTeO3 nanoparticles are synthesized via a simple one-step method. The as-synthesized MnTeO3 nanoparticles with uniform size show good biocompatibility. In particular, MnTeO3 nanoparticles exhibit a high photothermal conversion efficiency (η = 26.3%), which is higher than that of gold nanorods. Moreover, MnTeO3 nanoparticles also have high MRI performance. The longitudinal relaxivity (r1) value of MnTeO3 nanoparticles is determined to be 8.08 ± 0.2 mm −1 s−1, which is higher than that of clinically approved T1-contrast agents Gd-DTPA (4.49 ± 0.1 mm −1 s−1). The subsequent MnTeO3 nanoparticles-mediated photothermal therapy displays a highly efficient ablation of tumor cells both in vitro and in vivo with negligible toxicity. It is demonstrated that MnTeO3 nanoparticles can serve as promising theranostic agents with great potentials for MRI-guided photothermal therapy. |
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| Keywords: | cancer treatments magnetic resonance imaging manganese tellurite nanoparticles photothermal therapies theranostic agents |
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