The induction of PANoptosis in KRAS-mutant pancreatic ductal adenocarcinoma cells by a multispecific platinum complex

Science China Chemistry - Oncogenic KRAS reprograms pancreatic ductal adenocarcinoma (PDAC) cells to a state that is awfully resistant to apoptosis. An alternative coping strategy is to trigger a...     

Power spectrum in the MIM waveguide with single tooth-structure and nano-structure detection

The paper proposes the metal–insulator–metal (MIM) waveguides with different tooth-shapes (rectangle-tooth and triangle-tooth) and calculates the corresponding power spectrums by discrete Fourier transform. The finite difference time domain (FDTD) simulation results show that the spectrum transformations reveal the significant differences in the two structures with the same tooth-depth, such as amplitudes, amplitudes difference and spacing of the two peaks. The study will be useful in waveform modulation in the communication wavelength. Furthermore, the spectrum may also be used to detect different nanostructures based on the corresponding transformations.     

Reconfigurable Plasmonic Nanostructures Controlled by DNA Origami

Precise surface functionalization and reconfigurable capability of nanomaterials are essential to construct complex nanostructures with specific functions.Here we show tire assembly of a reconfigurable plasmonic nanostructure,which executes both conformational and plasmonic changes in response to DNA strands.In this work,different sized gold nanoparticles(AuNPs)were arranged site-specifically on the surface of a DNA origami clamp nanostructure.The opening and closing of the DNA origami clamp could be precisely controlled by a series of strand emplacement reactions.Therefore,the patterns of these AuNPs could be switched between two different configura-tions.The observed plasmon band shift indicates the change of the plasmonic interactions among the assembled AuNPs.Our study achieves the construction of reconfigurable nanomaterials with tunable plasmonic interactions,and will enrich the toolbox of DNA-based functional nanomachinery.     

Ring-Stacking Water Clusters: Morphology and Stabilities

The structures and interaction energies of water clusters with ring stacking motifs are studied by using ab initio calculations. The structures of the water clusters are constructed by stacking either single rings or multi-rings of tetramer, pentamer, and hexamer. We found that, in the single-ring-stacking motif, the most stable isomers exhibit an alternative clockwise-anticlockwise stacking pattern. We also show that four-layer single-ring-stacking isomers are not energetically favorable in comparison with those of two-layer multi-ring-stacking isomers. The relative stability of the isomers is also analyzed in terms of H-bond strength and elastic distortions of the water molecules.     

Electromechanical coupling dynamics of TBM main drive system

Nonlinear Dynamics - Tunnel boring machine (TBM) is seriously damaged due to excessive vibration, and its anti-vibration design is the key of the drive system design. At present, the coupling model...     

Palladium-catalyzed construction of poly-substituted indolizinones

We have developed a highly efficient one-pot approach to poly-substituted indolizinones from tertiary propargylic alcohols by using a palladium-catalyzed domino reaction. This reaction is proposed to proceed via successive aminopalladation, reductive elimination, and 1,2-shift. While our previous effort to the same skeleton via 2-iodoindolizinones selected α,β-unsaturated esters, terminal acetylenes, or boronic acids as coupling partners, this strategy introduces new functional groups at the C2 position of indolizinone core with (hetero)aryl halides or diallyl carbonate, expanding the substrate scope for decoration at the C2 site. Furthermore, a new preparation route to tertiary propargylic alcohols for this study is described to rapidly diversify the molecular framework.     

Phosphine-Functionalized Syndiotactic Polystyrenes: Synthesis and Application to Immobilization of Transition Metal Nanoparticle Catalysts

The precise control of monomer sequence and stereochemistry in copolymerization is of much interest and importance for the synthesis of high performance materials, but studies toward this goal have met with only limited success to date. The coordination polymerization of diphenylphosphinostyrene (p-StPPh₂ and o-StPPh₂) and its copolymerization with styrene (St) by (C₅Me₄SiMe₃)Sc(CH₂C₆H₄NMe₂-o)₂ have been achieved for the first time to afford a new series of phosphine functionalized syndiotactic polystyrene. By the design of the polymer structure, the copolymer of o-StPPh₂ and St (poly(o-StPPh₂-alt-St)-b-sPS) containing o-StPPh₂ and St atactic alternating copolymer block and syndiotactic polystyrene block (sPS) showed excellent thermal stability and chemical resistance. The simple combination of the triphenylphosphine and syndiotactic polystyrene realized the stable immobilization of metal nanoparticles to afford highly robust metal@poly(o-StPPh₂-alt-St)-b-sPS nanocatalysts at high temperature and various atmospheres. The Cu@poly(o-StPPh₂-alt-St)-b-sPS catalyst can serve as a highly efficient heterogeneous catalyst for the synthesis of quinoline derivatives by acceptorless dehydrogenative coupling of o-aminobenzylalcohol with ketones.     

Electrophoretic ratcheting of spherical particles in well/channel microfluidic devices: Making particles move against the net field

We examine the electrophoresis of spherical particles in microfluidic devices made of alternating wells and narrow channels, including a system previously used to separate DNA molecules. Our computer simulations predict that such systems can be used to separate spherical particles of different sizes that share the same free-solution mobility. Interestingly, the electrophoretic velocity shows an inversion as the field intensity is increased: while small particles have higher velocities at low field, the situation is reversed at high fields with the larger particles then moving faster. The resulting nonlinearity suggests that asymmetric pulsed electric fields could be used to build separation ratchets: particles then have a net size-dependent velocity in the presence of a zero-mean external field. Exploiting the inversion mentioned above, we show how to design pulsed field sequences that make particles move against the mean field (an example of negative mobility). Finally, we demonstrate that it is possible to use pulsed fields to make particles of different sizes move in opposite directions, even though their charge have the same sign.     

基于紫外刻写相移光栅的温度应力同时测量传感器

传统光纤光栅传感器存在温度应力交叉敏感的问题,无法同时测量被测物体的温度应力变化情况。针对这种情况,提出一种新型的利用紫外光刻写相移光栅的方法,在刻写光栅前用电极放电的方法去除掉极小一段光纤的光敏性,使光纤原有的均匀周期分布状态被破坏,从而形成相移光栅,并对其进行理论分析。此种相移光栅的透射光谱存在2个明显的谐振峰,利用2个峰对温度和应变灵敏度不同的性质,可以通过建立解调矩阵来实现温度与应力的同时测量。实验结果表明:利用此种方法制成的相移布拉格光栅能够较为精确地实现温度、应力的同时测量,所制作的传感器温度灵敏度最高可达9.51 pm/℃,灵敏度方差低于2.125×10?7,应变灵敏度最高可达0.767 pm/με,灵敏度方差低于2.156×10?10。