排序方式: 共有24条查询结果,搜索用时 15 毫秒
1.
Lu Lu Xirong Huang Yanjie Dong Yu Huang Xinmeng Pan Xingyue Wang Miao Feng Yun Luo Duowen Fang 《Mikrochimica acta》2015,182(7-8):1509-1517
2.
Xingyue He Qing Wu Chen Hou Min Hu Qigang Wang Xia Wang 《Angewandte Chemie (International ed. in English)》2023,62(15):e202218766
Some cellular enzymatic pathways are located within a single organelle, while most others involve enzymes that are located within multiple compartmentalized cellular organelles to realize the efficient multi-step enzymatic process. Herein, bioinspired by enzyme-mediated biosynthesis and biochemical defense, a compartmented nanoreactor (Burr-NCs@GlSOD) was constructed through a self-confined catalysis strategy with burr defect-engineered molybdenum disulfide/Prussian blue analogues (MoS2/PBA) and an interfacial diffusion-controlled hydrogel network. The specific catalytic mechanism of the laccase-like superactivity induced hydrogelation and cascade enzyme catalytic therapy were explored. The confined hydrogelation strategy introduces a versatile means for nanointerface functionalization and provides insight into biological construction of simulated enzymes with comparable activity and also the specificity to natural enzymes. 相似文献
3.
Ya Zhou Lijuan Zhu Biaoxiang Liu Weiping Xu Xingyue Yang Yi Liu Bankang Ruan Shujuan Yi Baoshuai Liang Guoqi Dong Jiaguo Huang 《Angewandte Chemie (International ed. in English)》2023,62(52):e202315457
Drug-induced renal failure (DIRF) poses a serious medical complication with high mortality risk. However, early diagnosis or prognosis of DIRF remain challenging, as current methods rely on detecting late-stage biomarkers. Herein we present a library of zwitterionic unimolecular hemicyanines (ZCs) available for constructing activatable reporters to detect DIRF since its initial stage. Zwitterionic properties of these probes are achieved through interspersedly integrating alkyl sulfonates and quaternary ammonium cations onto hemicyanine skeleton, which result in record low plasma protein binding (<5 %) and remarkable renal clearance efficiencies (≈96 %). An activatable reporter ZCRR is further developed by masking the optimal candidate ZC6 with a tetrapeptide specifically cleavable by caspase-8, an initiating indicator of apoptosis. In living mice with cisplatin-induced DIRF, systematically administered ZCRR efficiently accumulates in kidneys and responds to elevated caspase-8 for near-infrared fluorescence signals ‘turn-on’, enabling sensitive detection of intrarenal apoptosis 60 h earlier than clinical methods, and precise evaluation of apoptosis remediation effects by different medications on DIRF mice. As it's urinary excretable, ZCRR also allows for remote detection of DIRF and predicting renoprotective efficacy through in vitro optical urinalysis. This study thus presents unimolecular renal clearable scaffolds that are applicable to developing versatile activatable reporters for renal diseases management. 相似文献
4.
Nonlinear Dynamics - This article investigates the issue of hybrid-triggered control for fuzzy Markov jump system under input saturation. First, a hybrid-triggered control scheme is presented,... 相似文献
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Ladie Kimberly De La Cruz Xiaoxiao Yang Anna Menshikh Maya Brewer Wen Lu Minjia Wang Siming Wang Xingyue Ji Alyssa Cachuela Haichun Yang David Gallo Chalet Tan Leo Otterbein Mark de Caestecker Binghe Wang 《Chemical science》2021,12(31):10649
Carbon monoxide as an endogenous signaling molecule exhibits pharmacological efficacy in various animal models of organ injury. To address the difficulty in using CO gas as a therapeutic agent for widespread applications, we are interested in developing CO prodrugs through bioreversible caging of CO in an organic compound. Specifically, we have explored the decarboxylation–decarbonylation chemistry of 1,2-dicarbonyl compounds. Examination and optimization of factors favorable for maximal CO release under physiological conditions led to organic CO prodrugs using non-calorific sweeteners as leaving groups attached to the 1,2-dicarbonyl core. Attaching a leaving group with appropriate properties promotes the desired hydrolysis–decarboxylation–decarbonylation sequence of reactions that leads to CO generation. One such CO prodrug was selected to recapitulate the anti-inflammatory effects of CO against LPS-induced TNF-α production in cell culture studies. Oral administration in mice elevated COHb levels to the safe and efficacious levels established in various preclinical and clinical studies. Furthermore, its pharmacological efficacy was demonstrated in mouse models of acute kidney injury. These studies demonstrate the potential of these prodrugs with benign carriers as orally active CO-based therapeutics. This represents the very first example of orally active organic CO prodrugs with a benign carrier that is an FDA-approved sweetener with demonstrated safety profiles in vivo.1,2-Dicarbonyl compounds with FDA-approved sweeteners as leaving groups deliver CO for protection against acute kidney injury in mice. 相似文献
6.
应用原子吸收分光光度法对济南市健康老年人血清中铜、锌、镁含量进行了测定。结果表明,健康老年人血液铜、锌水平低,但铜、锌比值正常,而镁的含量则较高。提示这组健康老年人未患心、脑血管疾病及糖尿病的原因可能与铜、锌、镁等微量元素有关。 相似文献
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We estimate the kinematic measure of one convex domain moving to another under the groupG of rigid motions in
n
. We first estimate the kinematic formula for the total scalar curvature D
0gD
1
Rdv of then–2 dimensional intersection submanifold D
0gD
1. Then we use Chern and Yen's kinematic fundamental formula and our integral inequality to obtain a sufficient condition for one convex domain to contain another in
n
(4). Forn=4, we directly obtain another sufficient condition in 4. 相似文献
8.
The pK of p-(methylamino)biphenyl, 1, on our Li scale, pK(Li) = 22.09, compared to the cesium scale, pK(Cs) = 28.60. For hexamethyldisilazane, HMDS, pK(Li) = 23.05, pK(Cs) = 29.26. These results are those for the monomers in THF; corrections were made for dimers present in some cases. The pK(Li) of these two amines fit well the previously found correlation with Hartree-Fock calculations at 6-31+g(d) using RLi coordinated with three dimethyl ethers as a computational model for RLi in THF. The results are also compared with earlier pK(Li)s reported from equilibria with lithium amides in which aggregation was not considered. 相似文献
9.
Wang Gang Wang Dan Mei Xingyue Huang Min Zhang Li Li Xuemei 《Journal of Radioanalytical and Nuclear Chemistry》2022,331(9):3927-3933
Journal of Radioanalytical and Nuclear Chemistry - In this study, Shengmai Yin (SMY) was irradiated at doses of 2, 3, 5, and 7 kGy of electron-beam, to investigate the effects of electron... 相似文献
10.