An LC–MS/MS method for quantification of HR011303, a novel highly selective urate transporter 1 inhibitor in beagle dogs and the application to a pharmacokinetic study

HR011303 is a novel and highly selective urate transporter 1 (URAT1) inhibitor. In this study, a sensitive liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed and validated for quantification of HR011303 in beagle dog plasma. Plasma samples were pretreated with protein‐precipitation extraction by acetonitrile and added with a trifluoromethyl substituted analog of HR011303 as internal standard. The chromatographic separation was performed on a Shiseido C₁₈ column (100 × 4.6 mm, i.d., 5 μm) by mobile phases consisting of 5 mm ammonium–formic acid (100:0.1) and acetonitrile–formic acid (100:0.1) solutions in gradient elution. The MS detection was conducted in electrospray positive ionization with multiple reactions monitoring at m/z 338 → 240 for HR011303 and m/z 328 → 230 for the internal standard using 25 eV argon gas collision induced dissociation. The established LC–MS/MS method showed good selectivity, sensitivity, precision and accuracy. The plasma pharmacokinetics of HR011303 in beagle dogs following both oral and intravenous administration were then successfully evaluated using this LC–MS/MS method.     

富氮多孔有机聚合物催化制备α⁃氰基肉桂酸乙酯

α-氰基肉桂酸乙酯作为含多种官能团的缺电子烯烃, 是一种极具应用价值的有机合成反应底物, 主要通过催化Knoevenagel缩合反应获得. 本文以多聚甲醛和三聚氰胺为前驱体, 采用溶剂热法制备富氮多孔有机聚合物mPMF, 经K₂CO₃处理得到K₂CO₃-mPMF-X(X=1, 10, 50). 考察了mPMF在苯甲醛和氰乙酸乙酯Knoevenagel缩合反应中的催化性能, 通过mPMF与K₂CO₃-mPMF-X催化活性的比较, 探讨了碱性强弱对Knoevenagel缩合反应的影响, 并对催化反应机理进行了探索. 结果表明, 催化剂中丰富的氮物种为反应提供了碱性环境和大量的碱性活性位点, 催化剂碱性强弱的控制是催化合成α-氰基肉桂酸乙酯的关键因素. mPMF在甲醇溶剂中于60 ℃反应3 h后, 苯甲醛转化率为97%, 目标产物选择性在99.9%以上.     

膨胀石墨/聚苯胺/Fe_3O_4复合材料的制备及吸波性能

采用原位聚合方法制备了膨胀石墨/聚苯胺(EG/PANI)复合材料,将Fe_3O_4负载于EG/PANI表面,得到具有电磁吸收性能的EG/PANI/Fe_3O_4复合材料.通过扫描电子显微镜(SEM)、X射线衍射仪(XRD)、傅里叶变换红外光谱仪(FTIR)及矢量网络分析仪(VNA)等对复合材料的形貌、成分和吸波性能进行了研究.吸波性能分析结果表明,当掺杂浓度为0.05 mol/L,匹配厚度d=2 mm时,样品的最小反射损耗(RLmin)在8.64 GHz处达到-37 dB.随着掺杂浓度的增加,最小反射损耗峰向低频移动,对应的匹配厚度逐渐变厚.材料的介电弛豫极化、涡流损耗及λ/4模型的干涉相消现象出现的双峰,使EG/PANI/Fe_3O_4复合材料在电磁波吸收领域有一定的应用前景.     

二阶椭圆方程的下解及Holder连续的一个新证明(英文)

借助于检试函数和迭代技术,在系数弱光滑性假设条件下,本文研究了二阶椭圆方程的下解和正则性.进一步借助于局部估计和Poincare不等式,我们给出了Holder连续的一个新证明.     

CeO_2和Y_2Ba_1Cu_1O_(5-δ)共同掺杂对Y_1Ba_2Cu_3O_(7-δ)的超导电性及其晶格结构的影响

采用固相反应法成功制备出一批Y123与Y211的摩尔比为1∶0.47的混合物,并在此混合物的基础上掺入CeO2,掺入的比例x分别为0.5wt%、1.0wt%、2.0wt%、3.0wt%、4.0wt%。采用了X-射线衍射仪对样品的晶格结构进行了分析,测量结果表明:x=1.0wt%时掺杂效果最好,同时也充分说明Y123的晶格结构与其超导电性之间存在着一种内在的必然关联。并通过对其测试临界转变温度以及转变宽度,测量结果也充分验证了上述结论。     

Simplified fabrication of high areal capacitance all-solid-state micro-supercapacitors based on graphene and MnO2 nanosheets

A universal simplified strategy was developed to fabricate all-solid-state planar micro-supercapacitors with high areal capacitance (~355 mF/cm²), based on interdigital patterned films of 2D pseudocapacitive MnO₂ nanosheets and electrochemically exfoliated graphene.     

On the Cauchy problem for Wigner–Poisson–BGK equation in the Wiener algebra

In this paper, we prove the existence and uniqueness of the local mild solution to the Cauchy problem of the n‐dimensional (n≥3) Wigner–Poisson–BGK equation in the space of some integrable functions whose inverse Fourier transform are integrable. The main difficulties in establishing mild solution are to derive the boundedness and locally Lipschitz properties of the appropriate nonlinear terms in the Wiener algebra. Copyright © 2015 John Wiley & Sons, Ltd.     

Two bifurcation routes to multiple chaotic coexistence in an inertial two-neural system with time delay

Nonlinear Dynamics - In this article, we establish an inertial two-neural system with time delay and illustrate the stable coexistence of three chaotic attractors that arise via two different...     

Sphericity Test for High Dimensional Data Based on Random Matrix Theory

In this article we study test of sphericity for high-dimensional covariance matrix in the general population based on random matrix theory. When the sample size is less than data dimension, the classical likelihood ratio test has poor performance for test of sphericity. Thus, we propose a new statistic for test of sphericity by using the higher moments of spectral distribution of the sample covariance matrix, and derive the asymptotic distribution of the statistic under the null hypothesis. Simulation results show that the proposed statistics can effectively improve the power of the test of sphericity for high dimensional data, and have especially significant effects for Spiked model, on the basis of controlling the type-one error probability.