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螺旋桨结构的三苯胺荧光团既能作为强的电子供体,又能作为潜在的聚集诱导发光(AIE)骨架.同时,三苯胺衍生物很容易通过简单的反应进行结构修饰,如醛基、氨基、硼酸基、卤素、乙炔基等取代的三苯胺能够发生缩合反应或偶联反应等,进一步功能化.因此,功能性三苯胺类化合物被广泛用于太阳能电池、荧光染料、固态发光材料和荧光探针的分子设计中.根据三苯胺基荧光探针的检测对象,将其分为阳离子、阴离子和中性小分子荧光探针三类,并从分子的结构和性能出发,重点综述了近五年来国内外三苯胺基荧光探针在分子设计、合成与检测应用方面的最新进展.展望未来,构建近红外发光和高量子效率的AIE荧光探针值得关注. 相似文献
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在信息技术和知识经济快速发展的今天,创新已成为民族振兴的关键,国家兴旺的基石.创新教育是现代教育的灵魂,要培养勇于创新的综合型人才,在现代教育中实施创新教育已成为人们的共识.而创新能力的培养,教育起着举足轻重的作用.在教学中应有意识地加强学生的创新意识和创新能力的培养,而中学物理实验教学则在这一培养链条中扮演着不可替代的角色.因此,实验教学在物理教学乃至整个创新教育中具有重要的地位.我们必须以这样的视角,认识目前中学物理实验教学的现状和解决问题的思路. 相似文献
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用Co2(CO)8与CH3CSNH2反应制得产物Ⅰ,又用Na2Fe(CO)4与Ⅰ反应制得产物Ⅱ(Ⅰ:Co3(μ3-S)(CO)7(CH3CSNH),Ⅱ:Co2Fe(μ3-S)(CO)7(CH3CSNH).通过元素分析。IR、UV、1HNMR、MS表征并用X射线衍射法测得Ⅱ的单晶结构.该簇合物属三斜晶系、PT空间群,晶胞参数:a=0.9203(1),b=1.1296(2),c=1.1425(2)nm;α=116.40°(2),β=101.92°(2),γ=92.58°(1);z=2,V=1.2162nm3,Dc=1.698cm3,μ=21.89cm-1.结构分析表明,Co2FeS构三角锥分子骨架,所有CO均为端基配体,S1为面桥基配体,CH3CSNH为双齿配体,与Co、Fe形成五元环结构. 相似文献
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Yanyan Kong Xingqin Zhou Guoxian Cao Xijie Xu Meifen Zou Xiaofeng Qin Rongjun Zhang 《Journal of Radioanalytical and Nuclear Chemistry》2011,287(1):93-101
Pyrroloquinoline quinone (PQQ), an essential nutrient, antioxidant, redox modulator and nerve growth factor found in a class
of enzymes called quinoproteins, was labeled with 99mTc by using stannous fluoride (SnF2) method. Radiolabeling qualification, quality control and characterization of 99mTc-PQQ and its biodistribution studies in mice were performed and discussed. Effects of pH values, temperature, time and reducing
agents concentration on the radiolabeling yield were investigated. The quality control procedure of 99mTc-PQQ was determined by thin layer chromatography (TLC), radio high-performance liquid chromatography (RHPLC) and paper electrophoresis
methods. The average radiolabeling yield was 94 ± 1% under optimum conditions of 0.99 mg of PQQ, 30 μg of SnF2, 0.5 mg of ethylenediaminetetraacetic acid disodium salt (EDTA-2Na) and 18.5 MBq of Na99mTcO4 at pH 6 and 25 °C with a response volume of 1 ± 0.1 mL. 99mTc-PQQ was stable and anionic. Lipid–water partition coefficient of 99mTc-PQQ was −1.49 ± 0.16. The pharmacokinetics parameters of 99mTc-PQQ were t
1/2α = 18.16 min, t
1/2β = 100.45 min, K
12 = 0.013 min−1, K
21 = 0.017 min−1, K
e = 0.016 min−1, AUC (area under the curve) = 1040.78 ID% g−1 min and CL (plasma clearance) = 0.096 mL min−1. The dual-exponential equation was Y = 10.88e−0.038t
+ 5.21e−0.0069t
. The biodistribution of 99mTc-PQQ was studied in ICR (Institute for Cancer Research 7701 Burhelme Are., Fox Chase, Philadelphia, PA 1911 USA) mice. In
vitro autoradiographic studies clearly showed that the 99mTc-PQQ radioactivity accumulated predominantly in the hippocampus and cortex, which had a high density of N-methyl-d-aspartate Receptor (NMDAR). The enrichment can be blocked by NMDAR redox modulatory site antagonists-ebselen (EB) and 99mTc-PQQ is therefore a promising candidate for the molecular imaging of NMDAR. To date, however, there have been no studies
characterizing 99mTc-PQQ. 相似文献
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Gu G Wang H Liu P Fu C Li Z Cao X Li Y Fang Q Xu F Shen J Wang PG 《Chemical communications (Cambridge, England)》2012,48(22):2788-2790
Novel bisaryl maleimide derivatives to mimic natural kinase inhibitors were prepared through click chemistry. A highly selective hit was discovered in a 124-kinase-assay, and docking studies revealed a π-π stacking interaction with the Phe67 at the P-loop of GSK-3β kinase. 相似文献
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本文用循环伏安曲线和恒电位极化方法考察了具有金属薄层的p型单晶外延硅(p+/p-Si)阴极在碱溶液中的光电化学性能。结果表明,镀有钨-镍合金层的p+/p-Si阴极和镀有钯的p+/p-Si阴极,使氢析出的光电流明显增加。前者的电位比光电流达到相同值的空白p+/p-Si电极向正方移动了0.3V以上,后者移动0.25V。同时对p型外延硅(p+/p-Si)阴极比p型单晶硅(p-Si)阴极光响应较大的实验结果作了初步解释。扫描电镜结果显示,钨-镍合金沉积层是由许多不连续的“团块”构成的,而不是连续层。 相似文献
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InfluenceofBuffer-LayerThicknessonPerformanceofWaveguideModulators¥XAINGYunnan;WANGKuiru;YUGuoxian;XUDaxiong(BeijingUnversity... 相似文献