生物可降解医用聚氨酯及其应用

生物可降解医用聚氨酯由于其优良的生物相容性、降解性、功能化修饰和力学性能可调控等优点,逐渐引起研究者的关注,尤其在药物传递和组织工程支架等方面可望具有广阔的应用前景。结合本课题组开展的工作,本文综述了生物可降解医用聚氨酯材料在结构、功能化设计及医学应用上的研究进展,并展望了其在医学材料中的发展前景。     

Effect of trastuzumab on the micellization properties,endocytic pathways and antitumor activities of polyurethane-based drug delivery system

Polyurethane micelles (PM)-based nanovehicles have shown great potential in targeted delivery of therapeutics and diagnostics into tumors.However,the pathways of PMs entering cancer cells and the action mechanism of targeting ligands have yet to be understood.In this contribution,the actively-targeted PM were developed using trastuzumab as a model targeting group.It was found that PM were mainly taken up by SKOV-3 tumor cells via a micropinocytosis process,while the incorporation of trastuzumab to PM enabled a receptor-mediated endocytosis of nanocarriers in cancer cells,leading to more efficient cell entry and enhanced anticancer efficacy of chemotherapeutic drugs both in vitro and in vivo.This study is advantageous to the understanding of the action mechanism of trastuzumab,and significant for the construction of improved formulations for targeted delivery and precise therapy.     

第二类曲线积分的一题多解举例

为能熟练掌握第二类曲线积分的计算方法,在习题课中适当讲解一题多解的例题,有利于引导学生掌握常用的几种计算方法,举例如下:     

Preparation and characterization of controlled heparin release waterborne polyurethane coating systems

In this study, to improve hemocompatibility of biomedical materials, a waterborne polyurethane (WPU)/heparin release coating system (WPU/heparin) is fabricated via simply blending biodegradable WPU emulsions with heparin aqueous solutions. The surface compositions and hydrophilicity of these WPU/heparin blend coatings are characterized by attenuated total reflectance infrared spectroscopy (ATR-FTIR) and water contact angle measurements. These WPU/heparin blend coatings show effectively controlled release of heparin, as determined by the toluidine blue method. Furthermore, the biocompatibility and anticoagulant activity of these blend coatings are evaluated based on the protein adsorption, platelet adhesion, activated partial thromboplastin time (APTT), thrombin time (TT), hemolysis, and cytotoxicity. The results indicate that better hemocompatibility and cytocompatilibity are obtained due to blending heparin into this waterborne polyurethane. Thus, the WPU/heparin blend coating system is expected to be valuable for various biomedical applications.     

生物医用磷脂化聚氨酯的设计、制备与性能

聚氨酯因其具有优异的力学性能和良好的生物相容性广泛地应用于医疗领域.但医用聚氨酯常常会引起蛋白吸附、血小板激活、凝血、血栓和补体激活等不良生物学反应,使其应用受到限制.仿生物膜的磷脂表面被认为是和人体最亲和的表面,聚氨酯磷脂化是提高医用聚氨酯材料生物相容性的非常有效的手段之一.近年来国内外课题组在生物医用磷脂化聚氨酯的设计、制备与生物相容性等方面开展了大量的工作,取得了重要的研究进展.本文综述了磷脂改进医用聚氨酯的最新研究成果,指出含氟磷脂化聚氨酯和可降解的磷脂聚氨酯因其优异的性能,代表了该领域的发展方向并具有重要的应用前景.     

分段函数的求导方法

分段函数f(x)的求导步骤可归结为:一、如果函数在各段开区间内可导,则可求出它在各开区间内的导数.二、判断分界点x_0处的可导性:1.若函数在x_0点不连续,则它在x_0点不可导.2.若函数在x_0点连续,且在x_0的邻域内(x_0除外)可导,则(1)当(?)f′(x)存在,设为A时,函数f(x)在x_0点可导,且f′(x_0)=A;     

基于现实场景导入的高分子通识课程建设

为了培养符合新时代需求的高素质拔尖人才，打造一流的高分子通识课程，本文分析了传统高分子通识课程教学中存在的痛点问题，从教学内容、授课方式和考核方式等方面提出改革思路，并在《高分子与人类生活》教学实践过程中重构适合跨专业学生的课程框架，搭建现实场景导入的知识模块，探索现实场景导入的“探究式-小班化”教学方法，推进以现实场景为基础的全过程考核，实现了良好的教学效果。该教学改革思路可以推广到其他专业的通识课程和公共课程建设。