A Novel Mononuclear Copper（Ⅱ） Complex：Crystal Structure and DNA Cleavage Ability

The reaction of N-tosylatirdine with 1,2-diaminopropane in dry benzene solution yields an intermediate H2L, N,N,N',N'-tetrakis(2-(p-tolylsulfonyl)aminoethyl) propane-1,2-diamine. The mononuclear copper(Ⅱ) complex, [CuLH2O]·H2O, was synthesized by the reaction between the intermediate and copper(Ⅱ) in absolute methanol. The complex has been characterized by IR, UV-vis and X-ray diffraction technology, and its crystal crystallizes in the orthorhombic system, space group Pbca with a = 15.589(1), b = 21.897(2), c = 27.645(2) , V = 9436.4(1) 3, Dc = 1.352 g/cm3, Z = 8, Mr = 960.68, F(000) = 4040, μ(MoKa) = 0.698 mm-1, S = 0.98, R = 0.0537 and wR = 0.1180 for 5804 observed reflections (I > 2σ(I)). In the crystal structure, a one-dimensional chain is formed by abundant hydrogen bond interactions. The interaction of the complex with DNA was monitored using agarose gel electrophoresis. The result shows that the complex can transform the supercoiled to nicked and liner forms, and has a concentration-dependent cleavage activity.     

简明不对称合成天然蚂蚁生物碱(+)-MonomorineⅠ

运用Martin还原法高立体选择性构建顺式四氢吡咯,再经过非均相催化加氢脱保护,同时亲核闭环形成3,5-二取代吲哚里西丁双环结构。通过此方法由已知γ-内酰胺为原料5步合成天然蚂蚁生物碱(+)-MonomorineⅠ,总收率可达56%,产物与5位差向异构体的比大于20∶1。     

通过耦合降低随机行走的扩散速度(英文)

研究一个耦合的离散时间马尔可夫随机行走模型,将两个行走者耦合成对,通过改变演化到每一步时行走方向的分布情况,使得每个行走者有更大的概率向着它的共轭行走者的方向演化.在这种耦合方式下,增加耦合强度会使随机行走的扩散速度下降.最关键的问题是演化方向的分布情况,步长的分布情况只起次要作用.因为耦合,成对的行走者将进入某种同步状态.这种同步状态正是扩散速度下降的原因.