| A Novel Mononuclear Copper（Ⅱ） Complex：Crystal Structure and DNA Cleavage Ability |
| |
| 引用本文： | 周红,李木子,潘志权,黄齐茂,胡学雷.A Novel Mononuclear Copper（Ⅱ） Complex：Crystal Structure and DNA Cleavage Ability[J].结构化学,2011,30(3):312-317. |
| |
| 作者姓名： | 周红 李木子 潘志权 黄齐茂 胡学雷 |
| |
| 作者单位： | Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan 430073, China |
| |
| 基金项目： | Supported by the National Natural Science Foundation of China，the Foundation of the Innovative Group of the Education Department of Hubei Province，the Natural Science Foundation of the Science & Technology Department of Hubei Province |
| |
| 摘 要： | The reaction of N-tosylatirdine with 1,2-diaminopropane in dry benzene solution yields an intermediate H2L, N,N,N',N'-tetrakis(2-(p-tolylsulfonyl)aminoethyl) propane-1,2-diamine. The mononuclear copper(Ⅱ) complex, CuLH2O]·H2O, was synthesized by the reaction between the intermediate and copper(Ⅱ) in absolute methanol. The complex has been characterized by IR, UV-vis and X-ray diffraction technology, and its crystal crystallizes in the orthorhombic system, space group Pbca with a = 15.589(1), b = 21.897(2), c = 27.645(2) , V = 9436.4(1) 3, Dc = 1.352 g/cm3, Z = 8, Mr = 960.68, F(000) = 4040, μ(MoKa) = 0.698 mm-1, S = 0.98, R = 0.0537 and wR = 0.1180 for 5804 observed reflections (I > 2σ(I)). In the crystal structure, a one-dimensional chain is formed by abundant hydrogen bond interactions. The interaction of the complex with DNA was monitored using agarose gel electrophoresis. The result shows that the complex can transform the supercoiled to nicked and liner forms, and has a concentration-dependent cleavage activity.
|
| 关 键 词： | 单核铜配合物 晶体结构 DNA 切割能力 氢键相互作用 X射线衍射技术 琼脂糖凝胶电泳 紫外可见光谱 |
A Novel Mononuclear Copper(Ⅱ) Complex:Crystal Structure and DNA Cleavage Ability |
| |
| ZHOU Hong,LI Mu-Zi,PAN Zhi-Quan,HUANG Qi-Mao,HU Xue-Lei.A Novel Mononuclear Copper(Ⅱ) Complex:Crystal Structure and DNA Cleavage Ability[J].Chinese Journal of Structural Chemistry,2011,30(3):312-317. |
| |
| Authors: | ZHOU Hong LI Mu-Zi PAN Zhi-Quan HUANG Qi-Mao HU Xue-Lei |
| |
| Institution: | Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan 430073, China |
| |
| Abstract: | The reaction of N-tosylatirdine with 1,2-diaminopropane in dry benzene solution yields an intermediate H2L, N,N,N',N'-tetrakis(2-(p-tolylsulfonyl)aminoethyl) propane-1,2-diamine.The mononuclear copper(Ⅱ) complex, CuLH2O]·H2O, was synthesized by the reaction between the intermediate and copper(Ⅱ) in absolute methanol. The complex has been characterized by IR,UV-vis and X-ray diffraction technology, and its crystal crystallizes in the orthorhombic system,space group Pbca with a = 15.589(1), b = 21.897(2), c = 27.645(2) (A), V= 9436.4(1) (A)3, Dc = 1.352g/cm3, Z = 8, Mr = 960.68, F(000) = 4040,μ(MoKa) = 0.698 mm-1, S = 0.98, R = 0.0537 and wR =0.1180 for 5804 observed reflections (I > 2σ(I)). In the crystal structure, a one-dimensional chain is formed by abundant hydrogen bond interactions. The interaction of the complex with DNA was monitored using agarose gel electrophoresis. The result shows that the complex can transform the supercoiled to nicked and liner forms, and has a concentration-dependent cleavage activity. |
| |
| Keywords: | mononuclear copper(Ⅱ) complex hydrogen bond interaction DNA cleavage activity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
