常山酮中间体的合成工艺改进

以2-乙酰呋喃为起始原料,经扩环、甲基化、去质子化、亲核加成、缩酮化、Rh/C催化氢化及水解等反应合成了常山酮中间体--1-(3-甲氧基哌啶-2-基)丙酮,总收率40.2%,其结构经¹H NMR和ESI-MS确证。     

化学与生物转化法合成帕立骨化醇

以维生素D2(1)为原料,通过七步有机合成反应和一次生物转化,成功获得了帕立骨化醇9,并得到了一条新的合成帕立骨化醇的路线,收率为3.24%.该合成方法路线短,操作简便,收率较文献中的方法有较大提高.所有产物结构经1H NMR,13C NMR和MS表征.     

Generating 10-40 MeV high quality monoenergetic electron beams using a 5 TW 60 fs laser at Tsinghua University

A unique facility for laser plasma physics and advanced accelerator research has recently been built at Tsinghua University. This system is based on a Tsinghua Thomson scattering X-ray source (TTX), which combines an ultrafast TW laser with a synchronized 45 MeV high brightness linac. In our recent laser wakefield acceleration experiments, we have obtained 10-40 MeV high quality monoenergetic electron beams by running the laser at 5 TW peak power. Under certain conditions a very low relative energy spread of a few percent can be achieved. Absolute charge calibration for three different scintillating screens has also been performed using the linac system.