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The catalytic cross‐dehydrogenative coupling (CDC) reaction has received intense attention in recent years. The attractive feature of this coupling process is the formation of a C? C bond from two C? H moieties under oxidative conditions. In this Focus Review, recent advances in the palladium‐catalyzed CDC reactions of C(sp2)? H bond are summarized, with a focus on the period from 2011 to early 2013. 相似文献
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Yan Zhou Jinjian Li Han Yuan Rui Su Yue Huang Yiyou Huang Zhe Li Yinuo Wu Haibin Luo Chen Zhang Ling Huang 《Molecules (Basel, Switzerland)》2021,26(10)
Phosphodiesterase 2 (PDE2) has been regarded as a novel target for the treatment of Alzheimer’s disease (AD). In this study, we obtained (R)-LZ77 as a hit compound with moderate PDE2 inhibitory activity (IC50 = 261.3 nM) using a high-throughput virtual screening method based on molecular dynamics. Then, we designed and synthesized 28 dihydropyranopyrazole derivatives as PDE2 inhibitors. Among them, compound (+)-11h was the most potent PDE2 inhibitor, with an IC50 value of 41.5 nM. The molecular docking of PDE2-(+)-11h reveals that the 4-(trifluoromethyl)benzyl)oxyl side chain of the compound enters the H-pocket and forms strong hydrophobic interactions with L770/L809/F862, which improves inhibitory activity. The above results may provide insight for further structural optimization of highly potent PDE2 inhibitors and may lay the foundation for their use in the treatment of AD. 相似文献
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A palladium-catalyzed oxidative C-H bond functionalization/ortho-acylation of acetanilides using easily accessible aldehyde as the acyl source is described. In the presence of a Pd(TFA)(2) catalyst and tert-butylhydroperoxide at 90 °C in general, an array of ortho-acylacetanilides can be afforded in good yields. 相似文献
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Li Xu Zheng Tingting Zhang Lan Zhao Songtao Chen Yinuo Wei Miaojin Shang Chunyan Bao Jun Zeng Jie 《中国科学:化学(英文版)》2020,63(12):1705-1710
Science China Chemistry - Photocatalytic reduction of CO2 into value-added products is a promising strategy for mitigating environmental and energy problems simultaneously. Herein, we developed Au... 相似文献
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利用视频跟踪技术和Tracker软件,通过运动时序图和李萨如图展示了不同数量复合摆构成的耦合摆的多种运动形式,包括两个复合摆的同振幅同方向振动、同振幅反方向振动、拍振以及3个和4个摆之间的能量转移运动.这种实验演示方法有助于学生加深对耦合摆运动规律的认识. 相似文献
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Dr. Qinglan Zhao Dr. Xinxin Lu Yinuo Wang Dr. Shangqian Zhu Yushen Liu Dr. Fei Xiao Prof. Dr. Shi Xue Dou Dr. Wei-Hong Lai Prof. Dr. Minhua Shao 《Angewandte Chemie (International ed. in English)》2023,62(33):e202307123
The conventional industrial production of nitrogen-containing fertilizers, such as urea and ammonia, relies heavily on energy-intensive processes, accounting for approximately 3 % of global annual CO2 emissions. Herein, we report a sustainable electrocatalytic approach that realizes direct and selective synthesis of urea and ammonia from co-reduction of CO2 and nitrates under ambient conditions. With the assistance of a copper (Cu)-based salphen organic catalyst, outstanding urea (3.64 mg h−1 mgcat−1) and ammonia (9.73 mg h−1 mgcat−1) yield rates are achieved, in addition to a remarkable Faradaic efficiency of 57.9±3 % for the former. This work proposes an appealing sustainable route to converting greenhouse gas and waste nitrates by renewable energies into value-added fertilizers. 相似文献
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Tek Long Chan Dr. Yinuo Wu Pui Ying Choy Prof. Dr. Fuk Yee Kwong 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(47):15802-15814
Transition‐metal‐free cross‐coupling reactions have been a hot topic in recent years. With the aid of a radical initiator, a number of unactivated arene C? H bonds can be directly arylated/functionalized by using aryl halides through homolytic aromatic substitution. Commercially available or specially designed promoters (e.g. diamines, diols, and amino alcohols) have been used to make this synthetically attractive method viable. This protocol offers an inexpensive, yet efficient route to aromatic C? C bond formations since transition metal catalysts and impurities can be avoided by using this reaction system. In this article, we focus on the significance of the reaction conditions (e.g. bases and promoters), which allow this type of reaction to proceed smoothly. Substrate scope limitations and challenges, as well as mechanistic discussion are also included. 相似文献
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城市噪声作为一种污染源,给人们的生活带来不便;同时噪声中蕴含的能量没有被合理利用,造成浪费。为了解决此问题,该文设计引入了点缺陷的声子晶体、纤维层、压电材料复合结构,对入射噪声进行有效吸收并在点缺陷处对入射声压有较明显的声压加强。采用有限元和边界元的方法,对该复合结构的降噪发电效果进行数值模拟。结果显示在输入声压为2 Pa时,声子晶体结构带隙1.1 kHz处,吸声系数达到0.6,压电片有最高的输出电压0.5 V,输出功率密度达到308.49μW/cm~3。与传统降噪结构相比能更好地实现对声能的吸收与利用。 相似文献