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Ning Liang Yuk-Man Li Zouyan He Wangjun Hao Yimin Zhao Jianhui Liu Hanyue Zhu Erika Kwek Ka-Ying Ma Wen-Sen He Zhen-Yu Chen 《Molecules (Basel, Switzerland)》2021,26(12)
Rutin (R) and quercetin (Q) are two widespread dietary flavonoids. Previous studies regarding the plasma cholesterol-lowering activity of R and Q generated inconsistent results. The present study was therefore carried out to investigate the effects of R and Q on cholesterol metabolism in both HepG2 cells and hypercholesterolemia hamsters. Results from HepG2 cell experiments demonstrate that both R and Q decreased cholesterol at doses of 5 and 10 µM. R and Q up-regulated both the mRNA and protein expression of sterol regulatory element binding protein 2 (SREBP2), low-density lipoprotein receptor (LDLR), and liver X receptor alpha (LXRα). The immunofluorescence study revealed that R and Q increased the LDLR expression, while only Q improved LDL-C uptake in HepG2 cells. Results from hypercholesterolemia hamsters fed diets containing R (5.5 g/kg diet) and Q (2.5 g/kg diet) for 8 weeks demonstrate that both R and Q had no effect on plasma total cholesterol. In the liver, only Q reduced cholesterol significantly. The discrepancy between the in vitro and in vivo studies was probably due to a poor bioavailability of flavonoids in the intestine. It was therefore concluded that R and Q were effective in reducing cholesterol in HepG2 cells in vitro, whereas in vivo, the oral administration of the two flavonoids had little effect on plasma cholesterol in hamsters. 相似文献
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BaTiO_3纳米颗粒的聚丙烯酰胺凝胶法合成及光催化降解甲基红性能 总被引:1,自引:0,他引:1
采用聚丙烯酰胺凝胶法合成了BaTiO3纳米颗粒,利用X射线衍射、傅里叶变换红外光谱、透射电镜和紫外-可见漫反射光谱对样品进行了表征.结果表明,以柠檬酸酸为络合剂、pH=2且在700°C焙烧时可制备出单相BaTiO3纳米颗粒,其形状较为规整,近似呈球形,平均粒径约为55nm,光学带隙值为3.25eV.以偶氮染料甲基红为目标降解物,研究了BaTiO3纳米颗粒的光催化性能.结果表明,在紫外光照射下该纳米颗粒表现出较高的催化活性,光催化机理主要为光生空穴的直接氧化. 相似文献
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m值逻辑函数的谱分解式及广义Bent函数的递归构造 总被引:1,自引:0,他引:1
本文用概率方法得到m值逻辑函数Chrestenson循环谱的分解式,据此考察了m值广义Bent函数一些新的性质,给出了递归构造m(m≠2mod4)值广义Bent函数的一般方法. 相似文献
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Journal of Solid State Electrochemistry - The surface activation treatment of Li-rich materials with glacial acetic acid (GAA, a unitary organic weak acid) has been systematically investigated. The... 相似文献
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建立了一种利用顶空-气相色谱-质谱进行易燃液体的检测和分类的有效方法。以凹版油墨为模型样品体系,利用顶空-气相色谱-质谱鉴定了样品中的易挥发组分。考察了平衡温度、平衡时间和组分含量等特性参数。利用外标法测定了组分含量,结果显示该方法的相对标准偏差为0.88%~2.88%,加标回收率为92.8%~103.1%。采用该方法对多种实际样品进行了定性和定量分析,并用混合溶剂闪点预测模型计算了样品的闪点,与闪点实测值进行了比较。结果表明,该方法可用于易燃液体实际样品闪点的预测,实现化学品的分类,闪点预测值与实测值最大偏差仅为3.2℃。该方法为易燃液体实际样品的分类提供了一种新颖、高效和便捷的技术。 相似文献
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对于Oldroyd-B型黏弹性流体,本文应用格子Boltzmann方法(LBM),实现了流体在二维1:3扩张流道及3:1收缩流道中流动的数值模拟,获得了黏弹性流体在扩张和收缩流道中的流场分布.结合颗粒的受力和运动规则,基于点源颗粒模型,数值分析了颗粒在扩张流和收缩流中的沉降过程和特征,讨论了颗粒相对质量和起始位置以及雷诺数Re和威森伯格数Wi对颗粒沉降特征的影响.结果表明,颗粒相对质量和起始位置以及Re对颗粒沉降轨迹和落点影响较大,而Wi的影响则较小. 相似文献
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