Recent Developments on Five-Component Reactions

Multicomponent reactions (MCRs) have inherent advantages in pot, atom, and step economy (PASE). This important green synthetic approach has gained increasing attention due to high efficiency, minimal waste, saving resources, and straightforward procedures. Presented in this review article are the recent development on 5-compoment reactions (5CRs) of the following six types: (I) five different molecules A + B + C + D + E; pseudo-5CRs including (II) 2A + B + C + D, (III) 2A + 2B + C, (IV) 3A + B + C, (V) 3A + 2B, and (VI) 4A + B. 5CRs with more than five-reaction centers are also included.     

Ultrafast Fluorescence Spectroscopy via Upconversion and Its Applications in Biophysics

In this review, the experimental set-up and functional characteristics of single-wavelength and broad-band femtosecond upconversion spectrophotofluorometers developed in our laboratory are described. We discuss applications of this technique to biophysical problems, such as ultrafast fluorescence quenching and solvation dynamics of tryptophan, peptides, proteins, reduced nicotinamide adenine dinucleotide (NADH), and nucleic acids. In the tryptophan dynamics field, especially for proteins, two types of solvation dynamics on different time scales have been well explored: ~1 ps for bulk water, and tens of picoseconds for “biological water”, a term that combines effects of water and macromolecule dynamics. In addition, some proteins also show quasi-static self-quenching (QSSQ) phenomena. Interestingly, in our more recent work, we also find that similar mixtures of quenching and solvation dynamics occur for the metabolic cofactor NADH. In this review, we add a brief overview of the emerging development of fluorescent RNA aptamers and their potential application to live cell imaging, while noting how ultrafast measurement may speed their optimization.     

The combination of TsNBr2/TsNH2 as the nitrogen/halo source for the aminobromination of β-methyl-β-nitrostyrenes catalyzed by Mn(OAc)2

The combination of N,N-dibromo-p-tolunesulfonamide (4-TsNBr₂) and TsNH₂ was found to be an efficient halogen/nitrogen source for the aminohalogenation of β-methyl-β-nitrostyrenes with manganese (II) acetate as the catalyst in the presence of 4 Å molecular sieves. The reaction results in vicinal bromoamino nitroalkanes with the opposite regioselectivity comparing with those reported, which was also confirmed by X-ray structural analysis.     

Dynamic Modulation of Enzyme Activity by Near-Infrared Light

Engineering near-infrared (NIR) light-sensitive enzymes remains a huge challenge. A photothermal effect-associated method is developed for tailoring the enzymatic activity of enzymes by exposure to NIR light. An ultrasmall platinum nanoparticle was anchored in an enzyme to generate local heating upon NIR irradiation, which enhanced the enzyme activity without increasing bulk temperature. Following NIR irradiation, the enzyme activity was tailored rapidly and reversibly, and was modulated by varying laser power density and irradiation time. Four enzymes were engineered, including glucoamylase, glucose oxidase, catalase, and proteinase K with NIR-light sensitivity, and demonstrated their utility in practical applications such as photolithography and NIR light-responsive antibacterial or anticancer actions. Our investigation suggests that this approach could be broadly used to engineer enzymes with NIR-light sensitivity for many biological applications.     

非港湾式公交车站站点设置的研究

研究了在同一路段上非港湾式公交车站站点的分散式和集中式设置对道路 交通的影响. 在元胞自动机交通流NaSch模型上, 提出了考虑公交车站站点分散式和集中式 设置的双车道元胞自动机交通流模型, 通过计算机模拟和理论分析, 结果表明: 在开放边界条件下, 分散式公交车站点与集中式公交车站点相比, 影响道路交通通行能力作用显著的减小; 公交车站点之间的间隔、站台的长度、公交车停靠时间以及车流中公交车的比例对交通 流量有显著的影响.     

新型M-THGEM结构探测器的蒙特卡罗模拟研究

新型多层厚型气体电子倍增器（Multi-layers THick Gas Electron Multiplier,M-THGEM）和传统THGEM （厚型气体电子倍增器）相比,具有连续的雪崩区,能够在低气压和低电压下都有较高增益,结构更紧凑,易于大面积制作等优势。对M-THGEM探测器的工作原理及性能进行了模拟研究,首先通过有限元（ANSYS）软件对二层与三层结构的M-THGEM进行了建模,对电场和电势分布分别进行了模拟计算;再利用Garfield++程序包对M-THGEM探测器在不同低气压和不同工作电压下的增益、感生信号、正离子反馈率等性能进行了研究。模拟结果表明,三层结构M-THGEM在低气压（200 Torr）、纯He气体条件下,能够获得较稳定的增益（105）,输出信号的宽度在12 ns左右;同时,为降低正离子反馈率,本工作提出并研究了一种非对称的电压施加方式,结果表明,这种施加方式能有效降低正离子的反馈率。Compared to THGEM (Thick Gas Electron Multiplier), the novel Multilayer Thick Gaseous Electron Multiplier (M-THGEM) has many advantages, such as continuous avalanche zone, more compact structure, high gain at low pressure and low operating voltage, and easy to make large-area production. In the presented work, two types of the M-THGEM detector (two or three layers) were modeled, and their main principle and performances were also studied by simulation. Two types of the detector were molded and simulated by using the finite element software (ANSYS), and the electric field distribution and nodes information lists were figured out. The effective gain and induced signal from M-THGEM detector at different gas pressures and operating voltages were studied with the Garfield++ package. The simulation results shown that M-THGEM can obtain a stable higher gain around 105 in an environment where has a low pressure even in 200 Torr and within a pure inertia gas such as He. At this condition, the width of the induced signal from the three-layers structure is around 120 ns. Additionally, an asymmetric way of the applied voltage was studied and aim to reduce the efficiency of ion feedback, and our results show that this method is effective.     

微波辐射下一步合成4-芳基-2,6-二(3,3’-香豆素基)吡啶衍生物

3-乙酰基香豆素、芳醛和醋酸铵在醋酸溶剂中经微波辐射,一步合成了4-芳基-2,6-二(3,3’-香豆素基)吡啶衍生物,反应在5～8 min内完成,产率60%～86%,具有反应时间短、操作简便和环境友好等优点.所以产物经红外光谱、氢谱、质谱和元素分析表征.     

消随机媒质退化的复原处理

对于遭受随机媒质退化的成像,需要用统计方法和功率谱模型实施复原处理.首先探讨了统计模型的大气光学传递函数(OTF);其次,在等功率谱的假定下,用功率谱维纳(Wiener)滤波器进行复原处理;然后,使用局部统计算法作乘法性噪声滤波的复原,获得了满意的图像复原结果.     

Salt-assisted chemical vapor deposition of two-dimensional materials

Two-dimensional(2D) materials with atomic thickness are promising candidates for the applications in future semiconductor devices, owing to their fascinating physical properties and superlative optoelectronic performance. Chemical vapor deposition(CVD) is considered to be an efficient method for large-scale preparation of 2D materials toward practical applications.However, the high melting points of metal precursors and the thermodynamics instabilities of metastable phases limit the direct CVD synthesis of plenty of 2D materials. The salt has recently been introduced into the CVD process, which proved to be effective to address these issues. In this review, we highlighted the latest progress in the salt-assisted CVD growth of 2D materials, including layered and non-layered crystals. Firstly, strategies of adding salts are summarized. Then, the salt-assisted growth of various layered materials is presented, emphasizing on the transition metal chalcogenides of stable and metastable phases. Furthermore, strategies to grow ultrathin non-layered materials are discussed. We provide viewpoints into the techniques of using salt, the effects of salt, and the growth mechanisms of 2D crystals. Finally, we offer the challenges to be overcome and further research directions of this emerging salt-assisted CVD technique.