Recent Developments on Five-Component Reactions |
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| Authors: | Xiaoming Ma Sanjun Zhi Wei Zhang |
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| Institution: | 1.School of Pharmacy, Changzhou University, 1 Gehu Road, Changzhou 213164, China;2.Jiangsu Key Laboratory for the Chemistry of Low-Dimensional Materials, Huaiyin Normal University, Huai’an 223300, China;3.Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02125, USA |
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| Abstract: | Multicomponent reactions (MCRs) have inherent advantages in pot, atom, and step economy (PASE). This important green synthetic approach has gained increasing attention due to high efficiency, minimal waste, saving resources, and straightforward procedures. Presented in this review article are the recent development on 5-compoment reactions (5CRs) of the following six types: (I) five different molecules A + B + C + D + E; pseudo-5CRs including (II) 2A + B + C + D, (III) 2A + 2B + C, (IV) 3A + B + C, (V) 3A + 2B, and (VI) 4A + B. 5CRs with more than five-reaction centers are also included. |
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| Keywords: | multicomponent reaction five-component pseudo one-pot cascade consecutive green synthesis heterocycle pot atom step economy |
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