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1.
Ultrasound has been recognized as an exciting tool to enhance the therapeutic efficacy in tumor chemotherapy owing to the triggered drug release, facilitated intracellular drug delivery, and improved spatial precision. Aiming for a precise localized drug delivery, novel dendritic polyurethane-based prodrug (DOX-DPU-PEG) was fabricated with a drug content of 18.9% here by conjugating DOX onto the end groups of the functionalized dendritic polyurethane via acid-labile imine bonds. It could easily form unimolecular micelles around 38 nm. Compared with the non-covalently drug-loaded unimolecular micelles (DOX@Ph-DPU-PEG), they showed excellent pH/ultrasound dual-triggered drug release performance, with drug leakage of only 4% at pH 7.4, but cumulative release of 14% and 88% at pH 5.0 without and with ultrasound, respectively. The ultrasound responsiveness was attributed to the unique strawberry-shaped topological structure of the DOX-DPU-PEG, in which DOX was embedded in the skin layer of the hydrophobic DPU cores. With ultrasound, the DOX-DPU-PEG unimolecular micelles possessed enhanced tumor growth inhibition than free DOX but showed no obvious cytotoxicity on the tumor cells without ultrasound. Such feature makes them promising potential for precise localized drug delivery. 相似文献
2.
宋显花 《数学的实践与认识》2021,(3):182-185
设B(X)是维数大于等于3的复Banach空间X上有界线性算子全体构成的代数.设A∈B(X),若Ax=x,则称x∈X是算子A的固定点.Fix(A)表示A的所有固定点的集合.本文刻画了B(X)上保持算子的Jordan积的固定点的满射. 相似文献
3.
Analysis Mathematica - In this paper, we investigate general Lp-mixed brightness integrals which were defined by Yan and Wang. We give their extremal values and establish Brunn-Minkowski type... 相似文献
4.
Xiangxue Wang Shujun Yu Zhongshan Chen Wencheng Song Yuantao Chen Tasawar Hayat Ahmed Alsaedi Wei Guo Jun Hu Xiangke Wang 《中国科学:化学(英文版)》2017,60(1):107-114
To contribute to the understanding of Eu(III) interaction preperties on hydrous alumina particles in the absence and presence of fulvic acid (FA), the complexation properties of Eu(III) with hydrous alumina, FA and FA-alumina hybrids are studied by batch and time-resolved laser fluorescence spectroscopy (TRLFS) techniques. The continuous increase in the fluorescence lifetime of Eu-alumina and Eu-FA with increasing pH indicates that the complexation is accompanied by decreasing number of hydration water in the first coordination sphere of Eu(III). Eu(III) is adsorbed onto alumina particles as outer-sphere surface complexes of ≡(Al?O)?Eu· (OH)· 7H2O and ≡(Al?O)?Eu· 6H2O at low pH values, and as inner-sphere surface complexes as ≡(Al?O)2?Eu+· 4H2O at high pH. In FA solution, Eu(III) forms complexes with FA as (COO)2Eu+(H2O) x and the hydration water number in the first coordination sphere decreases with pH increasing. The formation of ≡COO?Eu?(O?Al≡)· 4H2O is observed on FA-alumina hybrids, suggesting the formation of strong inner-sphere surface complexes in the presence of FA. The surface complexes are also characterized by their emission spectra [the ratio of emission intensities of 5 D 0→7 F 1 (λ=594 nm) and 5 D 0→7 F 2 (λ=619 nm) transitions] and their fluorescence lifetime. The findings is important to understand the contribution of FA in the complexation properties of Eu(III) on FA-alumina hybrids that the clarification of the environmental behavior of humic substances is necessary to understand fully the behavior of Eu(III), or its analogue trivalent lanthanide and actinide ions in natural environment. 相似文献
5.
设X和Y是维数大于1的复Banach空间,A和B分别是B(X)和B(Y)中包含有限秩算子的范数闭子代数.A,B∈A,定义A。B=A+B-AB,称。为A,B的拟积.刻画了从A到B的双边保持算子的(左,右)拟可逆性或(左,右,半)拟零因子的可加满射的结构. 相似文献
6.
Change monitoring of distribution in time series models is an important issue.This paper proposes a procedure for monitoring changes in the error distribution of autoregressive time series,which is based on a weighed empirical process of residuals with weights equal to the regressors.The asymptotic properties of our monitoring statistic are derived under the null hypothesis of no change in distribution.The finite sample properties are investigated by a simulation.As it turns out,the procedure is not only able to detect distributional changes but also changes in the regression coefficient and mean.Finally,we apply the statistic to a groups of financial data. 相似文献
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8.
A convenient and regioselective sulfonylation/cyclization of 1,6-enynes with arylazo sulfones has been developed to access a series of sulfonylated γ-butyrolactams.The present reaction could be efficiently conducted under catalyst-and additive-free conditions,in which C-S and C-C bonds were selectively constructed in one-pot procedure. 相似文献
9.
The Laplacian spectrum of a graph consists of the eigenvalues (together with multiplicities) of the Laplacian matrix. In this article we determine, among the graphs consisting of disjoint unions of paths and cycles, those ones which are determined by the Laplacian spectrum. For the graphs, which are not determined by the Laplacian spectrum, we give the corresponding cospectral non-isomorphic graphs. 相似文献
10.