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2-[(3-Aminophenyl)sulfonyl] ethanol hydrogen sulfate (APSES) is an important intermediate for reactive dyes.It can be used to synthesize KN type reactive dyes, which have broad colour spectra,good water solubility, excellent adaptability for different dye technique,etc. Synthesis of APSES were currently developed by Kato Kuniok et al[1] and Sanki[2].Kato had attempted to synthesize of APSES by reaction of sodium benzenesulfinate as raw material with ethylene oxide to obtain 2-phenylsulfonyl ethanol(PSE). The PSE could further be nitrated and hydrogenated to obtain 2-[(3-aminophenyl)sulfonyl]ethanol (APSE). Finally,APSE was reacted with oleum to obtain 2-[(3-aminophenyl) sulfonyl] ethanol hydrogen sulfate (APSES). Sanki had discoved a new synthetic method for the PSE. The PSE was prepared by first reaction of thiophenol as raw material with chloroethanol, and then by oxidation with hydrogen peroxide.The above mentioned two methods are not easily be adopted in industries at home. The shortage and cost of the thiophenol and sodium benzenesulfinate are mainly limited. We modificated a new synthetic pathway for APSES by five steps. The experimental procedures are shown the following. 相似文献
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以自制或试剂级羧酸、酰氯为原料,通过酰氯化、胺基化反应,设计合成了15个含香兰素胺的酰胺结构的辣椒碱类似物。其结构经IR,MS,1HNMR表征,并用X射线单晶衍射测定了化合物W5和W11的晶体结构。体外抗肿瘤活性测试表明,该类化合物具有一定程度的抗肿瘤活性。化合物W1在100μg/ml时,对人宫颈癌细胞(HELA)、人肝癌细胞(SMMC-7721)、人口腔表皮癌细胞(KB)、人卵巢癌细胞(HO-8901)抑制率均达到90%以上。W13在100μg/ml时,对KB、HO-8901抑制率分别达到89.62%、90.36%。初步构效关系分析认为,含香兰素胺的酰胺结构片段为一活性基团。 相似文献
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5-甲基-7-羟基-2-苄硫基-1,2,4-三唑[1,5-a]嘧啶(MHB-TZP)是医药、农药的重要中间体.在医学上,它可应用于制备治疗心血管疾病的药物[1],在农药方面,随着新型超高效三唑并嘧啶磺酰胺类除草剂的崛起,它作为一种重要的合成中间体而倍受人们关注[1,2].本文以5-氨基-3-巯基-1,2,4-三唑(AMZ)、氯化苄和乙酰乙酸乙酯为原料,一步法合成了MHB-TZP,同时优化了反应条件,使目标产物的产率达到了56%以上.产品结构经熔点测定、红外光谱、核磁共振谱分析确认.反应式如下: 相似文献
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三硝基氯苯与水合肼反应,直接合成了2,4,6-三硝基苯肼(2),2与醛、酮试剂反应合成了6个新的苯腙化合物,其结构经1H NMR,IR和元素分析表征。抑菌试验表明,部分目标产物具有良好的抑菌活性。 相似文献
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