多层次系统的动态评价研究

针对多层次系统的动态评价问题,首先,应用极大不相关法筛选指标以去除重复的信息;其次,对指标进行一致化和无量纲化的预处理;再次,采用逐层纵横向拉开档次评价法确定评价对象在不同时刻的评价值;最后,应用时序几何平均算子来集结多个时间点的评价值,以得出最终的动态排序。这种方法没有丝毫主观色彩,适用于经济管理系统的动态评价问题。以评价电力企业的效益作为算例,说明了方法的应用价值。     

信息产业发展对经济增长影响的评价:以新疆兵团为例

为了较为客观合理地评价信息产业发展对经济增长的影响,在科学合理地构建评价指标体系的基础上,建立信息产业发展对经济增长影响的定量评价模型,并对模型的结果给出其合理的经济学意义.模型结果表明:不同的信息产业投入指标要素对经济增长的贡献率不同,为了实现经济的快速健康发展,应对不同的信息产业投入指标要素给予不同程度的关注;同时...     

2010上海世博会影响力的定量评估——影响力的点刺激连带效应定量评估模型

利用互联网数据,在合理假设的前提下,给出了上海世博会对上海旅游业影响的定量评估.利用线性加权综合分析法建立综合评价指标的线性模型,并从两个不同的角度,分别得出上海世博会对上海旅游业的综合评价指标,同时建立灰色系统预测模型,利用2006至2009年的评价指标,对2010年的评价指标进行预测.通过实际的增长值与预测增长值的...     

结构光光条中心点信度评价方法与应用

结构光三维测量中,光条中心点的提取是极其重要的步骤.现有方法对结构光条中心点提取都仅仅是标志中心点的位置,而中心点位置的可信与否,并未提及.对于一些特殊场合应用,例如室外复杂情况的测量,需要确定测量结果的可信程度.如何评价光条提取的中心点的可信程度成为亟待解决的关键问题.针对这一问题,对光条模型进行实际分析,给出了更为...     

Evaluation of particle acceptance for space particle telescope

The particle acceptance instead of the G-factors has been introduced for a particle telescope. The particle acceptance of a telescope module TEST is simulated by using the GEANT4 Monte-Carlo package. The results are presented and explained.     

Design,synthesis and biological evaluation of indole derivatives as novel inhibitors targeting B-Raf kinase

A series of novel indole derivatives were designed and synthesized and their inhibitory activity against B-Raf and HepG2 cell were also described. Among them, compounds 7a and 7b exhibited excellent potency, which showed the potential for further research as lead compounds.     

Synthesis and anti-integrase evaluation of novel calix[4]arene derivatives containing the triazolyl 1,3-diketo moiety

A series of novel calix[4]arene derivatives incorporating two triazolyl 1 3-diketo subunits in alternate positions at the lower rim were synthesized and screened for HⅣ integrase inhibition activity.The chemical structures of these compounds were confirmed by means of1H NMR 13C NMR,and ESI-MS.Preliminary bioassays indicated that calix[4]arene derivatives proved to be more active than p-tertbutylcalix[4]arene derivatives.In particular,compound 4g presented the most potent integrase strand transfer inhibitory activity with an IC50value of 6.1 mmol/L.     

An efficient one-pot three-component synthesis and antimicrobial evaluation of tetra substituted thiophene derivatives

A convenient one-pot three-component method for the preparation of tetra-substituted thiophene derivatives has been developed. Reaction of acetyl acetone 1, phenyl isothiocynate 2 and 2-chloromethyl derivatives 3a–3c in the presence of potassium carbonate afforded the target compounds, namely ethyl2-(4-acetyl-3-methyl-5-(phenylamino)thiophen-2-yl)-2-oxoacetate derivatives 4a–4e, ethyl 3-(4-acetyl-3-methyl-5-(phenylamino)thiophen-2-yl)-3-oxopropanoate derivatives 4f–4i, di((4-acetyl-3-methyl-5-phenylamino)thiophen-2-yl)ketone derivatives 4j–4n in reasonable overall yields. The synthesized compounds were screened for antimicrobial activity. The detailed synthesis, spectroscopic data and antimicrobial activities of synthesized compounds were reported.     

Design,synthesis and biological evaluation of E-ring modified evodiamine derivatives as novel antitumor agents

A series of novel E-ring modified evodiamine derivatives were designed and synthesized as antitumor agents. Their capacity to interfere with the catalytic activity of topoisomerase Ⅰ and Ⅱ was evaluated by the relaxation assay. In vitro antitumor activity results revealed that compound 12 showed good antitumor activity with a broad spectrum. Its binding modes with topoisomerase Ⅰ and Ⅱ were clarified by molecular docking.     

医学院校化学实验课程考核评价体系的探索与实践

探索建立形成性评价与结果性评价相结合的实验考核评价体系,不仅使教学评价环节更为客观公正、科学规范,同时对调动学生学习的积极性、主动性,激发教师的责任感等方面均收到了明显效果。