Mathematical model of hematopoiesis dynamics with growth factor-dependent apoptosis and proliferation regulations

We consider a nonlinear mathematical model of hematopoietic stem cell dynamics, in which proliferation and apoptosis are controlled by growth factor concentrations. Cell proliferation is positively regulated, while apoptosis is negatively regulated. The resulting age-structured model is reduced to a system of three differential equations, with three independent delays, and existence of steady states is investigated. The stability of the trivial steady state, describing cells dying out with a saturation of growth factor concentrations is proven to be asymptotically stable when it is the only equilibrium. The stability analysis of the unique positive steady state allows the determination of a stability area, and shows that instability may occur through a Hopf bifurcation, mainly as a destabilization of the proliferative capacity control, when cell cycle durations are very short. Numerical simulations are carried out and result in a stability diagram that stresses the lead role of the introduction rate compared to the apoptosis rate in the system stability.     

离散神经网络指数稳定改进条件

研究了一类时滞离散神经网络指数稳定及鲁棒稳定问题.结合线性矩阵不等式技术,构造了一个新的广义李亚普诺夫函数,得到了新的指数稳定条件.数值算例表明与以往文献中的结果相比,新准则具有较弱的保守性.     

Well posedness and asymptotic behavior of a wave equation with distributed time‐delay and Neumann boundary conditions

This paper is concerned with the asymptotic behavior analysis of solutions to a multidimensional wave equation. Assuming that there is no displacement term in the system and taking into consideration the presence of distributed or discrete time delay, we show that the solutions exponentially converge to their stationary state. The proof mainly consists in utilizing the resolvent method. The approach adopted in this work is also used to other physical systems.     

Finite time stability and relative controllability of Riemann‐Liouville fractional delay differential equations

This paper firstly deals with finite time stability (FTS) of Riemann‐Liouville fractional delay differential equations via giving a series of properties of delayed matrix function of Mittag‐Leffler. We secondly study relative controllability of such type‐controlled system. With the help of the representation of solution, both Gram‐like type matrix and rank criterion are derived, which extend the corresponding results for linear systems.     

Bifurcations and spatiotemporal patterns in a ratio‐dependent diffusive Holling‐Tanner system with time delay

In this paper, we concentrate on the spatiotemporal patterns of a delayed reaction‐diffusion Holling‐Tanner model with Neumann boundary conditions. In particular, the time delay that is incorporated in the negative feedback of the predator density is considered as one of the principal factors to affect the dynamic behavior. Firstly, a global Turing bifurcation theorem for τ = 0 and a local Turing bifurcation theorem for τ > 0 are given. Then, further considering the degenerated situation, we derive the existence of Bogdanov‐Takens bifurcation and Turing‐Hopf bifurcation. The normal form method is used to study the explicit dynamics near the Turing‐Hopf singularity. It is shown that a pair of stable nonconstant steady states (stripe patterns) and a pair of stable spatially inhomogeneous periodic solutions (spot patterns) could be bifurcated from a positive equilibrium. Moreover, the Turing‐Turing‐Hopf–type spatiotemporal patterns, that is, a subharmonic phenomenon with two spatial wave numbers and one temporal frequency, are also found and explained theoretically. Our results imply that the interaction of Turing and Hopf instabilities can be considered as the simplest mechanism for the appearance of complex spatiotemporal dynamics.     

Cholera model incorporating media coverage with multiple delays

In order to investigate the impact of awareness programs and time delays on the cholera outbreaks, we propose a cholera epidemic model, incorporating awareness programs by media as a separate class and two time‐delay factors. The bifurcation theory is applied to explore the variety of dynamics of this model for various combinations of the delays when R₀>1. Moreover, we analyze the direction, stability, and period of the bifurcating periodic solutions arising through Hopf bifurcation by using the normal form concept and the center manifold theory. Finally, we present numerical simulations to verify the main theoretical results.     

Dynamics of a Predator-prey Model with Delay and Fear Effect

Recent manipulations on vertebrates showed that the fear of preda- tors, caused by prey after they perceived predation risk, could reduce the prey''s reproduction greatly. And it''s known that predator-prey systems with fear ef- fect exhibit very rich dynamics. On the other hand, incorporating the time delay into predator-prey models could also induce instability and oscillations via Hopf bifurcation. In this paper, we are interested in studying the com- bined effects of the fear effect and time delay on the dynamics of the classic Lotka-Volterra predator-prey model. It''s shown that the time delay can cause the stable equilibrium to become unstable, while the fear effect has a stabi- lizing effect on the equilibrium. In particular, the model loses stability when the delay varies and then regains its stability when the fear effect is stronger. At last, by using the normal form theory and center manifold argument, we derive explicit formulas which determine the stability and direction of periodic solutions bifurcating from Hopf bifurcation. Numerical simulations are carried to explain the mathematical conclusions.     

ALMOST PERIODICITY FOR AN IMPULSIVE PURE DELAY LOGISTIC EQUATION

By employing a fixed point theorem in cones,we investigate the existence of almost periodic solutions to an impulsive pure delay Logistic equation. A set of suffcient conditions for the existence of almost periodic solutions to the equation are obtained.     

无限时滞泛函微分方程概周期解的存在唯一性

对于无限时滞泛函微分方程,利用Liapunov泛函的方法,研究了方程概周期解的存在性、唯一性问题,得到了便于应用的概周期解的存在性、唯一性判据.     

The dynamics of an eco-epidemiological model with distributed delay

In this paper, the dynamical behavior of an eco-epidemiological model with distributed delay is studied. Sufficient conditions for the asymptotical stability of all the equilibria are obtained. We prove that there exists a threshold value of the conversion rate h beyond which the positive equilibrium bifurcates towards a periodic solution. We further analyze the orbital stability of the periodic orbits arising from bifurcation by applying Poore’s condition. Numerical simulation with some hypothetical sets of data has been done to support the analytical findings.