Low speed bearing fault diagnosis using acoustic emission sensors

In this paper, a new methodology for low speed bearing fault diagnosis is presented. This acoustic emission (AE) based technique starts with a heterodyne frequency reduction approach that samples AE signals at a rate comparable to vibration centered methodologies. Then, the sampled AE signal is time synchronously resampled to account for possible fluctuations in shaft speed and bearing slippage. The resampling approach is able to segment the AE signal according to shaft crossing times such that an even number of data points are available to compute a single spectral average which is used to extract features and evaluate numerous condition indicators (CIs) for bearing fault diagnosis. Unlike existing averaging based noise reduction approaches that require the computation of multiple averages for each bearing fault type, the presented approach computes only one average for all bearing fault types. The presented technique is validated using the AE signals of seeded fault steel bearings on a bearing test rig. The results in this paper have shown that the low sampled AE signals in combination with the presented approach can be utilized to effectively extract condition indicators to diagnose all four bearing fault types at multiple low shaft speeds below 10 Hz.     

模糊数学在飞机故障诊断中的应用

飞机故障征兆与故障原因问的隶属关系是模糊的，为此，将模糊数学方法引入到飞机故障诊断中，提出由历史数据及专家优序数综合确定模糊隶属度的方法，建立模糊诊断模型，并在计算机上实现飞机故障的模糊诊断。     

高磁场核磁共振波谱学在临床医学上的应用

本篇是有关以高磁场核磁共振(非成像)探讨生物体液如体尿及血浆于临床医学上、采样前处理以及一般用到之核磁共振技术,并从文献上举例说明如何利用核磁共振来诊断新陈代谢及病发状态。其成份组成在波谱上观察得到与否,主要靠分子运动以及浓度来决定,分子运动影响了核弛豫,各组成间所显现之不同弛豫可用来做波谱编排,因此不同之分子运动亦有可能做为诊断之依据。     

墨粉灌装车间噪声测试分析与控制

本文应用峰值频率声压级对比方法并结合相干分析技术对某墨粉灌装车间主噪声源进行了诊断，分析了声源特性，在此基础上提出了经济合理的治理措施，实施后取得了满意的结果，车间噪声达到了相应的国家标准。     

The Evolving Etiology of Bilateral Vocal Fold Immobility

In the past, bilateral vocal fold immobility (BVFI) occurred most commonly after thyroidectomy. However, no large series documenting the etiology of adult BVFI has been published within the past fifteen years. This study reviews the etiologic patterns of BVFI at our institutions. We compare BVFI from before and after 1980. We also review combined studies of unilateral vocal fold immobility (UVFI) to compare and unilateral versus bilateral etiologic trends. In comparison with previously published series, fewer cases of BVFI present today as a complication of thyroid surgery and more as the result of malignancies and nonsurgical trauma. Unfortunately, BVFI caused by malignancy is not usually an initial sign of local disease, but an ominous sign of recurrence or metastases. In comparing UVFI and BVFI we found that thyroidectomy causes a higher percentage of BVFI than of UVFI. Over one-third of UVFI cases were caused by neoplasm which further underscores the potential seriousness of immobile vocal folds and the need for careful investigation.     

Detecting Alzheimer's disease biomarkers: From antibodies to new bio-mimetic receptors and their application to established and emerging bioanalytical platforms – A critical review

The failure of therapeutic treatment of Alzheimer's disease (AD) patients can be related to the late onset of symptoms and, consequently, to a delayed pharmacological aid to counteract neurodegenerative progression. This is coupled to the fact that the diagnosis based on clinical criteria alone introduces high misdiagnosis rate. The availability of assessed biomarkers is therefore of crucial importance not only to counteract late diagnosis, but also to manage patients at high risk of AD development eligible for novel therapies. At the present time, amyloid-β peptides (Aβ_1-40 and Aβ_1-42 isoforms), alone or in combination with Tau protein (total and phosphorylated forms (p-tau)) constitute reliable AD biomarkers and result highly predictive of progression to AD dementia in patients with mild cognitive impairment (MCI), the earliest clinical presentation of AD. Improvement of existing diagnostic tools must take advantage of innovative bioanalytical approaches. In this review, starting from commercially available diagnostic platforms based on antibodies as recognition elements, we intended to provide a double point of view on the issue: 1) progresses achieved on innovative bioanalytical platforms (mainly sensors and biosensors) by using antibodies as consolidated receptors; 2) advance on promising bio-mimetic receptors alternative to antibodies in AD research, and their applications on conventional or innovative analytical platforms. In particular, we first focused on optical- (Propagating and Localized Surface Plasmon Resonance, named here SPR and LSPR) and electrochemical (voltammetric and impedimetric) transduction principles. Together with bioanalytical assays for AD biomarkers quantification, works aimed to investigate and understand their behavior, characteristics, and roles will also be considered in the discussion.     

Blood substitutes and other potential biomedical applications of fluorinated colloids

An oxygen carrying, heat-sterilized phospholipid-based emulsion of a fast excreted lipophilic fluorocarbon, perfluorooctyl bromide (perflubron), stabilized against molecular diffusion, has been developed to serve as a temporary blood substitute. It is expected to reduce exposure to donor blood and thereby help mitigate the pressure on our blood supply. A phase III clinical trial in Europe has demonstrated that use of the emulsion resulted in avoidance and reduction of donor blood transfusion in surgery patients. Further potential applications for fluorocarbon emulsions include use as a bridge to transfusion, treatment of myocardial ischemia and stroke, potentiation of radio and chemotherapy and preservation of organs destined for transplantation. Echogenic, injectable gaseous microbubbles, osmotically stabilized by perfluorohexane, provide an effective contrast agent for ultrasound imaging. Clinical trials have established improved imaging of the walls of the heart and, hence, assessment of cardiac function. The ability of improving detection of myocardial perfusion, blood flow abnormalities and solid tumors is also being investigated. Various families of fluorinated amphiphiles with modular molecular structures and polar heads derived from natural products have been synthesized. Due to their highly hydrophobic perfluoroalkylated tail chains, these amphiphiles readily self-assemble into stable fluorinated vesicles, tubules and other organized molecular systems with distinctive properties. Fluorosurfactants also allowed preparation of direct, reverse, apolar and multiple emulsions and gels. These fluorinated colloids have potential for the delivery of drugs and other bioactive materials, and provide unique tools in biomedical research.     

Fundamental Frequency Histograms Measured by Electroglottography During Speech: A Pilot Study for Standardization

This study was designed to develop a database for the electroglottographic measurement of fundamental frequency (Fo) in normal subjects in running speech, for reference in the diagnosis and follow-up of dysphonic patients. A prospective pilot study included 20 healthy male volunteers without laryngeal disorder. Electroglottographic recordings of speaking Fo during connected speech (French) were obtained from two texts with different prosodic content. Fo histograms were sensitive to the variation of speaking Fo between both texts. Graphic representation of the range and distribution of the Fo of the speaker were designed as normalized Fo histograms with plot lines at 5th and 95th percentiles. Less than 5% variability of Fo histograms was recorded when recording more than 15 subjects. This pilot study designed a graphic display of standardized electroglottographic Fo measurements during the physiological condition of connected speech. As the degree of Fo variability depends on the phonetic contents of the text and on the language spoken, a separate histogram for normal subjects needs to be developed in each country or at least for each voice laboratory, with a standard, previously chosen text.     

Integrated aerodynamic measurements

The myoelastic-aerodynamic model of phonation implies that aerodynamic factors are crucial to the evaluation of voice function. Subglottal pressure and mean flow rate represent the vocal power source. If they can be related to the magnitude of the radiated sound power, they may provide an index of vocal efficiency. Methods of evaluating the aerodynamic characteristics associated with the ventilatory and laryngeal systems are critically discussed, and normative aerodynamic values for use in diagnosis and physiologic investigations are presented. Measurements having excellent time resolution of the glottal flow wave and of pressure changes in the vicinity of the larynx itself demonstrate the importance of study vocal tract acoustics.