Psychogenic spasmodic dysphonia: A case study with expert opinions

Spasmodic (spastic) dysphonia (SD) is considered by some to be a neurologic syndrome and by others a symptom complex of multiple etiologies, neurologic and psychogenic. A case of a 26-year-old female psychiatric nurse with psychogenic SD (PSD) is presented. The dysphonia was alleviated within one session of voice therapy. Psychogenic etiology was established by the author, based on three diagnostic criteria—symptom incongruity, symptom reversibility, and symptom psychogenicity. Seven nationally recognized voice experts listened to audio-recorded samples of the patient's pre- and posttherapy voice during conversational speech. The experts agreed that the dysphonia was psychogenic and characterized it as staccato-like speech, effortful phonation, and interrupted flow of speech; six characterized it with intermittent voice arrests (voice stoppages); five with hoarse-harsh voice; and four with waxing and waning, strained-strangled phonation. These are often described as salient features of SD. Nevertheless, the experts disagreed among themselves as to whether the dysphonia was characteristic of SD and should be labeled as such. The author argues that as long as the voice characteristics and pathophysiologic findings that constitute SD are not well delineated, and as long as the diagnosis of SD is based on symptoms alone, patients with psychogenic or poorly understood voice disorders are likely to be misdiagnosed with organic (neurologic) SD and thus subjected to undue medical treatment. The author also argues that the debate over the etiology of SD can be resolved if SD is considered a neurologic syndrome, PSD a nonorganic phonatory disorder that mimics the syndrome, and if the voice symptoms and pathophysiologic characteristics of SD are well defined and agreed on.     

血液的红外吸收光谱分析及应用研究

开展红外光谱法的应用研究，对促进光测技术发展有重要作用。本文针对血液的红外光谱分析这一重要课题，提出了血液的红外吸收光谱分析新技术，通过对正常与异常血液的红外吸收光谱进行测量，分析并比较不同血液红外吸收光谱之间的差异，即可判断血样是否正常，其实验具有一定的先进性。文中分析了正常血样和异常血样的红外吸收光谱之间的差别，并给出了人的正常全血和血清与高糖全血的红外吸收光谱及分析结果，为进一步用于疾病诊断提供了实验依据。其研究结果对血液红外光谱分析并用于疾病诊断有重要价值。本文的研究为红外吸收光谱的测量及应用开辟了新的途径。     

Diagnostic analysis of experimental artefacts in DOSY NMR data by covariance matrix of the residuals

Multivariate curve resolution (MCR) has been applied to separate pure spectra and pure decay profiles of DOSY NMR data. Given good initial guesses of the pure decay profiles, and combined with the nonlinear least square regression (NLR), MCR can result in good separation of the pure components. Nevertheless, due to the presence of artefacts in experimental data, validation of a MCR model is still necessary. In this paper, the covariance matrix of the residuals (CMR), obtained by postmultiplying the residual matrix with its transpose, is proposed to evaluate the quality of the results of an experimental data set. Plots of the rows of this matrix give a general impression of the covariance in the frequency domain of the residual matrix. Different patterns in the plot indicate possible causes of experimental imperfections. This new criterion can be used as diagnosis in order to improve experimental settings as well as suggest appropriate preprocessing of DOSY NMR data.     

多级轴流压气机内部流场诊断问题的数值解法

多级轴流压气机内部流场诊断问题的数值解法张增产（清华大学力学系北京１０００８４）刘杰,叶大均（清华大学热能工程系北京１０００８４）关键词流场诊断;压气机１引言压气机是航空发动机中的核心部件。但是压气机的研制是一项既复杂又困难的工作,必须进行大量的实验...     

疫情下的仪器分析课程在线教学设计与探索——以绪论为例

During the wide spread of new coronavirus pneumonia, how to use information technology for carrying out the effective online teaching is an important question and discussion among teachers and students. Instrumental Analysis is an important basic course for the college students majoring in chemistry. In the time when teachers and students can only "hear" or "meet" online, how do we ensure the quality of online teaching? Taking the introduction part as an example, the author presents the process and fruits of their efforts to achieve better teaching and learning quality.     

Novel biosensor for microRNA-141 analysis based on lanthanide coordination polymer immobilized methylene blue as a signal label and 3D DNA walking machineEI北大核心CSCD

MicroRNA-141 is of great significance in the early diagnosis and treatment of related cancers. A biosensor was developed for the detection of microRNA-141 based on lanthanide coordination polymer immobilized methylene blue as a signal label and three-dimensional 3D DNA walking machine. First lanthanide coordination polymerCe-COPwith straw-sheaf like structure was successfully prepared with a large scale via a simplemild and rapid solution phase method at room temperature. The Ce-COP had a large specific surface area and can immobilize a large number of gold nanoparticles and methylene blue MB signal molecules. Thena 3D DNA walking machine was designed and introduced to the biosensor system for converting trace target microRNA-141 to a larger number of intermediate DNA and achieving significant signal amplification. The sensing platform exhibited recommendable stability and good selectivity. MicroRNA-141 could be accurately quantified with a linear range of 100 amol/L-100 nmol/L with the detection limit of 33 amol/L. This method provides a certain reference to high-sensitive detection for various cancer markers. © 2022, Youke Publishing Co.,Ltd. All rights reserved.     

Diagnosis for uncertain,dynamic and hybrid domains using Bayesian networks and arithmetic circuits

System failures, for example in electrical power systems, can have catastrophic impact on human life and high-cost missions. Due to an electrical fire in Swissair flight 111 on September 2, 1998, all 229 passengers and crew on board sadly lost their lives. A battery failure most likely took place on the Mars Global Surveyor, which unfortunately last communicated with Earth and thus ended its mission on November 2, 2006. Fault diagnosis techniques that seek to hinder similar accidents in the future are being developed in this article. We present comprehensive fault diagnosis methods for dynamic and hybrid domains with uncertainty, and validate them using electrical power system data. Our approach relies on the use of Bayesian networks, which model the electrical power system, compiled to arithmetic circuits. We handle in an integrated way varying fault dynamics (both persistent and intermittent faults), fault progression (both abrupt and drift faults), and fault behavior cardinality (both discrete and continuous behaviors). Our work has resulted in a software system for fault diagnosis, ProDiagnose, that has been the top performer in three of the four international diagnostics competitions in which it participated. In this paper we comprehensively present our methods as well as novel and extensive experimental results on data from a NASA electrical power system.     

Fault detection based on fractional order models: Application to diagnosis of thermal systems

The aim of this paper is to propose diagnosis methods based on fractional order models and to validate their efficiency to detect faults occurring in thermal systems. Indeed, it is first shown that fractional operator allows to derive in a straightforward way fractional models for thermal phenomena. In order to apply classical diagnosis methods, such models could be approximated by integer order models, but at the expense of much higher involved parameters and reduced precision. Thus, two diagnosis methods initially developed for integer order models are here extended to handle fractional order models. The first one is the generalized dynamic parity space method and the second one is the Luenberger diagnosis observer. Proposed methods are then applied to a single-input multi-output thermal testing bench and demonstrate the methods efficiency for detecting faults affecting thermal systems.     

永存原始玻璃体增生症的超声诊断价值

目的 探讨永存原始玻璃体增生症（PHPV）的超声表现，以提高对本病的诊断准确率。方法 回顾性分析9例经病 理检查证实的PHPV 患儿的超声表现，其中8例经超声检查确诊。结果 9 例（10 眼）PHPV 患儿在超声上均表现为患侧小眼球，眼轴缩短，玻璃体无回声区内出现从晶状体后连接到视乳头的圆锥形或漏斗状强回声团块，CDFI可见血流信号。5 例（6 眼）患侧眼球晶状体异常，表现为晶状体不同程度变形、轮廓不光滑，晶状体位置后移，前房变浅。3 例（3 眼）患侧玻璃体内出现絮状高回声。2 例（2 眼）患侧视网膜脱离。2 例（2 眼）患侧伴有白内障。超声诊断PHPV 的准确率为88.9%。结论 PHPV 的超声检查具有特征性的表现，有助于该病的鉴别诊断，指导制定治疗方案。     

Breath analysis: trends in techniques and clinical applications

Over the last few years, breath analysis for the routine monitoring either of metabolic disorders caused by specific diseases or occupational exposure to toxic substances has become more and more attractive due to its noninvasiveness.Several approaches have been proposed for sample collection, treatment, and analysis. This paper gives a critical overview of the analytical devices and procedures used for breath analysis. Results on the identification of chemicals in human breath for a selection of diseases are discussed.