高磁场核磁共振波谱学在临床医学上的应用

本篇是有关以高磁场核磁共振(非成像)探讨生物体液如体尿及血浆于临床医学上、采样前处理以及一般用到之核磁共振技术,并从文献上举例说明如何利用核磁共振来诊断新陈代谢及病发状态。其成份组成在波谱上观察得到与否,主要靠分子运动以及浓度来决定,分子运动影响了核弛豫,各组成间所显现之不同弛豫可用来做波谱编排,因此不同之分子运动亦有可能做为诊断之依据。

APPLICATIONS OF HIGH FIELD NMR SPECTROSCOPY TO CLINICAL MEDICINE

A review of recent developments and applications of high field NMR (i. e., non-imaging) of biological fluids such as urine and plasma to clinical medicine is given. Methods of sample pre-treatment and commonly used NMR techniques are discussed. Finally examples are drawn from the literature of how NMR can be used as an aid in the diagnosis of metabolic and diseased states. It is shown that molecular dynamics, together with concentration, play an important role in determining what species are observable. Molecular dynamics influences relaxation and differences in relaxation between species affords a means of spectral editing . Differences in molecular dynamics may also have diagnostic potential .