Effect of Notoginsenoside-Rg1 on the Expression of Several Proteins in the Striatum of Rat Models with Parkinson＇s Disease

After establishing hemi-Parkinsonian rat models, the relationships between neuron death and the expression of several proteins, such as c-Fos, GFAP, GDNF, NF-κB and some cytokines were determined. Therapeutics experiments with notoginsenoside-Rg1 were carried out. The research results show that the expressions of GFAP, NF-Kκ and c-Fos will obviously increase in the lesion side of the striatum and the expression of GDNF will decrease, which implies that the signal transduction pathway may participate in the apoptosis in neurons. The levels of some cytokines such as TNF-α, IL-1β in the striatum of PD rat models increased compared to those of normal rats. The results of the therapeutics experiments show that notoginsenoside-Rg1 may repress the immune inflammation response and regulate the immune function through the neuro-immune molecular network. Therefore, notoginsenoside-Rg1 can be used as an effective drug for anti-oxidation and anti-inflammation, and can be used in the therapy of Parkinson＇s disease（PD）.     

开关布局中本质不同的开关线路计算

通过对开关布局问题的研究，来解决一类象开关线路一样比较特殊，比较复杂的布局优化问题。从而寻找出这类问题的全局优化算法。本应用对称群对集合的作用，轨道，不动点等讨论了开关布局问题，给出了本质不同的开关线路个数的计算公式。     

小型高压冷阴极触发管性能分析

触发管作为一种高压开关，基于其导通时间短，可承受数千安培脉冲电流等特点被广泛应用于触发器、快脉冲产生器及大电流脉冲发生器中。随着系统精良小型化的发展需求，相应对触发管导通时间、脉冲电流和导通时间晃动等参数也提出了更高的要求。     

新型混合脂质体的制备及其与药物的分子识别研究

设计、合成了含核酸碱基的双亲化合物N6-十四酰基-9-辛基腺嘌呤三甲基溴化铵;用目标化合物和卵磷脂制备混合脂质体受体。分别研究了受体与巴比妥酸、核黄素药物在混合脂质体亲脂区通过互补氢键进行的分子识别。紫外可见光谱研究表明,底物巴比妥酸在258nm的吸收峰,核黄素在222nm,264nm的吸收峰随时间的延长而逐渐降低,这种减色作用归因于脂质体内的巴比妥酸和核黄素在亲脂区分别与双亲化合物上的腺嘌呤形成了氢键。     

Antiphase State in Passively Q-Switched Yb：YAG Microchip Lasers with a Nd,Cr：YAG as Saturable Absorber

We experimentally investigate the antiphase dynamics phenomenon that occurs in a diode-pumped passively Q-switched Yb:YAG multimode laser with a Nd,Cr:YAG saturable absorber. Due to the effect of spatial hole burning, the multimode lasers with one, two, or three modes at different pump power are observed, and the pulses sequences display classic antiphase dynamics.     

Optical and Acoustical Frequencies in a Nonlinear Helicoidal Model of DNA Molecules

We compare optical and acoustical frequencies in the Peyrard-Bishop-Dauxois model, i.e. an extended Peyrard-Bishop model, of DNA molecules. We discuss how ratio of those frequencies depends on a value of the harmonic constant of the helicoidal spring K. Also, we suggest that the most favourable mode could be a resonance mode.     

纳米PIC-I分子聚集体的超辐射和Z-扫描研究

分子聚集体在非线性光学和集成光学等领域有潜在的应用前景。纳米结构一维染料分子J—聚集体有许多既不同于单个分子又不同于体材料的奇异性质，即超辐射和巨光学非线性。这种超辐射是由于在几个本征态内振于强度结合在一起，得到一巨跃迁偶极于，因而是超辐射的。跃迁速率与耦合分子个数N成正比。分子聚集体的J—吸收和超辐射发射是共振的。利用Z—扫描技术测量PIC在不同配比下的非线性折射率、非线性吸收系数和非线性极化率。观测到随着链长变短，样品的三阶非线性极化率增大。对这种非线性增强的机制进行了分析和讨论。     

Self-assembly behaviour of amphiphilic diblock copolymer in selective solvents studied by synchrotron small-angle x-ray scattering

The aggregation behaviour of styrene-vinyl benzoic acid (PSm-b-PVBAn) amphiphilic diblock copolymers in selective solvents with different m and n was investigated by synchrotron small-angle x-ray scattering (SAXS). We have carried out a detailed analysis of scattering intensity, dimension, shape and microstructure of the diblock copolymers of narrow distribution in water, methanol, ethanol and isopropanol selective solvents, respectively. We have found that the aggregation behaviour of the copolymer depends on the nature of the solvent and the micelle forms fiat disc objects with the ratio of radius ω=0.4. The average radius gyration Rg of the copolymer decreases as solvents change from isopropanol to ethanol and to methanol, and increases with increasing pH in aqueous solution, but decreases with the addition of COCl2 in ethanol solvent. The scattering intensity of diblock copolymer micelle follows I(h) ∝ h^-α in different selective solutions, suggesting that the PSm-b-PVBAn coils have self-similar structure behaviour or a fractal structure in the selective solvents. All of these revealed that the aggregation behaviour of the diblock copolymer changes dramatically with experimental condition in the selective solvent. The increase of mass fractal dimension (Dm) from 2.12 to 2.47 indicates that the copolymer chain changes from a swollen coil to a rather compact disc in the course of changing solvents, decreasing surface fractal dimension (Ds) from 2.98 to 2.58 indicates that the copolymer micelle change from a rather rough surface to a smooth form in the course of increasing pH in aqueous solutions, and increasing Dm and Ds from 2.29 to 2.35 and 2.70 to 2.90, respectively, indicates the shrinkage of copolymer micelle to a rather compact and rough disc form by adding COCl2 in ethanol solvents.     

关于气体中有无速率为无穷大分子的再讨论

本文以较简捷的方法讨论了气体分子速率问题，给出了计算分子最大速率的理论公式，通过这些讨论可更加深入地理解气体中分子的运动情况，准确地理解麦克斯韦速率分布函数。