High-sensitive terahertz detection by parametric up-conversion using nanosecond pulsed laser

A high-sensitive terahertz detector operating at room temperature was demonstrated based on parametric upconversion.A nanosecond 1064-nm Nd:YAG laser was used to pump the parametric up-conversion detector and the upconversion from terahertz wave to NIR laser was realized in a lithium niobate crystal.The minimum detectable terahertz energy of 9 p J was realized with the detection dynamic range of 54 d B,which was three orders of magnitude higher than that of commercial Golay cell.The detectable terahertz frequency range of the detection system was 0.90 Thz–1.83 THz.Besides,the effects of pump energy and effective gain length on the detection sensitivity were studied in experiment.The results showed that higher pump energy and longer effective gain length are helpful for improving the detection sensitivity of parametric up-conversion detector.     

液相色谱-电喷雾电离三重四级杆质谱测定畜禽肝脏中维吉尼亚霉素M1的残留量

建立了动物肝脏组织中维吉尼亚霉素M1残留的液相色谱-电喷雾电离三重四级杆质谱(LC-ESI-MS/MS)的测定方法。样品经0.2 mol/L NH4H2PO4和乙酸乙酯提取,分散型固相萃取PSA填料净化,采用正离子扫描多反应监测(MRM)模式下液质联用仪进行定性和定量分析。该方法省去耗时的固相萃取过程,回收率在67.2%～90.3%之间,RSD<10.0%;检测限为0.5μg/kg,定量限为1.0μg/kg。     

固相萃取-高效液相色谱-串联质谱法检测粮食及其制品中的呕吐毒素

建立了粮食及其制品中呕吐毒素的高效液相色谱-串联质谱(HPLC-MS/MS)检测方法。样品经乙腈-水(84:16, v/v)溶液提取,HLB固相萃取柱富集净化,采用HPLC-MS/MS法对目标物进行定性确证和定量分析。在Phenomenex Kinetex C18柱(100 mm×4.6 mm, 2.6 μm)上以0.3‰氨水和乙腈为流动相进行梯度洗脱分离;质谱模式为电喷雾负离子监测模式。本方法的检出限(以信噪比(S/N)=3计)和定量限(以S/N=10计)分别为20 μg/kg和50 μg/kg;在20～1000 μg/L范围内呈现良好的线性关系,相关系数(r)大于0.99。对本底空白的面粉、大麦、大豆、大米、玉米粉、木薯干、小麦等7种代表性基质进行50、100、500 μg/kg 3个含量水平的添加试验,回收率范围为75.6%～111.0%,精密度(以相对标准偏差(RSD)计)不大于13.0%。本方法准确可靠,灵敏度高,经济实用,可替代较为昂贵的免疫亲和柱和多功能净化柱,较大地降低检测成本。     

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中性束注入是等离子体加热和电流驱动的重要方式之一,对EAST中性束注入的精确模拟对未来物理实验至关重要.采用ONETWO和NUBEAM程序模拟4MW、80keV中性束同向注入,不同的等离子体密度剖面导致不同的电子和离子加热、穿透功率损失、束驱动电流以及中子发射等.等离子体密度在以上的物理参数的演化中起着重要的作用.对EAST两种密度方案下中性束注入的效果进行了分析和讨论,并对未来中性束实验提供了一些预言性的建议和方案.     

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EAST中性束注入快离子损失研究

利用经典导心轨道程序ORBIT,结合平衡程序EFIT和输运程序TRANSP,计算了EAST中性束注入后快离子的损失情况.结果表明,4MW(80keV)氘离子的损失份额为29％,2MW(50keV)氘离子的损失份额为31％,损失的快离子有很强的局域性.     

Peptide backbone-copper ring structure: A molecular insight into copper-induced amyloid toxicity

Copper ions can promote amyloid diseases that are associated with amyloid peptides, such as type 2 diabetes (T2D), Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). However, the underlying molecular mechanism remains obscure. Here we present that Cu²⁺ is able to specifically bind to the backbone of T2D-related human islet amyloid polypeptide (hIAPP) by forming a ring structure, which causes the reduction of Cu²⁺ to Cu⁺ to produce reactive oxygen species (ROS) and the modulation of hIAPP aggregation. Nuclear magnetic resonance spectroscopy showed that Cu²⁺ bound to the backbone of a turn region, His18—Ser21, which is critical for hIAPP aggregation. Ab initio calculations and x-ray absorption fine structure analyses revealed that Cu²⁺ simultaneously bound with both the amide nitrogen and carbonyl oxygen on the peptide backbone, resulting in a ring structure, and causing the reduction of Cu²⁺ to Cu⁺ to form a hIAPP-Cu⁺ complex. 2',7'-dichlorodihydrofluorescin diacetate fluorescence measurements further indicated that this complex led to enhanced ROS levels in rat insulinoma cells. Additionally, thioflavin T fluorescence and atomic force microscopy measurements denoted that the backbone-Cu ring structure largely modulated hIAPP aggregation, including the inhibition of hIAPP fibrillation and the promotion of peptide oligomerization. These findings shed new light on the molecular mechanism of Cu²⁺-induced amyloid toxicity involving both the enhancement of ROS and the modulation of hIAPP aggregation.     

CO-FBMC/OQAM系统导频辅助的时域相位噪声补偿

对1550 nm铒镱共掺光纤放大器不同温度下的输出功率以及经过高温老化后的输出功率和光谱进行了实验研究。通过对比高温和常温下铒镱共掺光纤放大器的输出功率随泵浦功率的变化曲线,得出铒镱共掺光纤放大器在高温环境工作可提高输出功率,且不同长度的增益光纤对温度的敏感性不同的结论。以Arrhenius模型为加速老化模型对增益光纤进行温度为85℃、时间为876 h的加速老化实验,结果表明在常温环境工作5 y后铒镱共掺光纤放大器的输出功率将降低11.24%,放大的自发辐射噪声将增加4.1 dB,根据指数模型预测得到该放大器的使用寿命为7.57 y,这些结果为改善光纤放大器的输出性能和寿命预测提供了理论基础和实验依据。     

CO-FBMC/OQAM系统导频辅助的时域相位噪声补偿

针对相干光偏移正交调幅技术的多载波滤波器组传输(CO-FBMC/OQAM)系统,提出一种基于导频的时域相位噪声补偿算法。建立一个时域相位噪声补偿模型,即相位噪声用时域扩展的离散余弦变换(DCT)近似,相位噪声包括公共相位误差(CPE)和非CPE相位噪声,它们均可通过估计DCT系数来获得。为了计算这些DCT系数,先用基于导频的扩展卡尔曼滤波(EKF)估计CPE,然后将CPE补偿后一部分判决错误概率较高的数据舍弃,仅保留余下的CPE补偿后数据进行预判决用以预估发送端数据,最后在波特率为32 GBaud的背对背CO-FBMC/OQAM系统中对所提算法进行仿真验证。结果表明,对比一种改进的盲相位搜索(M-BPS)算法,所提算法仅有0.5%～2.0%的频谱效率下降。针对64阶QAM、子载波数M=256或512的系统,所提算法的线宽延迟乘积容忍度仍远大于M-BPS算法,但其复杂度仅为M-BPS算法的1/2。     

弹载激光陀螺惯导系统安装支架设计

以某型号武器控制系统使用激光陀螺的任务为背景,针对激光陀螺捷联惯导系统在地面动态导航测试中圆概率误差偏大的现象,要求给激光陀螺捷联惯导系统设计出性能优良的减振系统。通过双自由度分析法以及振动试验,指出原安装板刚性不足,导致谐振频率出现在激光陀螺的机抖频率附近以及其它需要减振的频率段,这些成为导航误差偏大的主要原因。把安装支架作为减振系统的一部分,应用有限元动态优化法设计出刚性增强的安装板和动态结构性能良好的安装支架来改善减振效果。经地面振动试验验证,新构建的减振系统的减振效果达到预期的设计要求,在国内战术武器激光陀螺应用方面取得很大进展,可以在飞行器上使用。