新书介绍

1.J.D.Roberts＆M.C.Caseiro:Basic Principles of Organic Chemistry.N.Y.,Benjamin,1977.《有机化学基本原理》 Roberts教授的《有机化学原理》,其第一版于1964年出版,当时就被公认为是一本比较好的有机化学教科书。最近,作者对原书作了较大的修改和增补,着重于应用热力学、量子化学、动力学及光谱学来解释有机化学中的一些问题,井用这些理论将有机化学中大量表面     

有机化学实验课程在线测试与学习平台的开发与实践

通过设计开发有机化学实验课程在线测试与学习平台改进有机化学实验教学。平台基于开源考试系统设计开发,可自适应多种终端和操作系统,无需单独安装客户端。构建符合有机化学实验教学目标和需求的实验能力评测指标体系,并在此基础上搭建平台、建设标准化试题库和教学资源库。平台除了具备考试系统的基本功能外,还可以根据测试结果推送相关学习资源,实现个性化精准教学。实践证明,平台可以帮助学生掌握实验知识,帮助教师了解教学效果。     

《有机化学》1999年进入《SCI-E》

美国科技情报所(Institute for Scientific Informafion)于1999年8月20日给本刊来信,通知《有机化学》(《Chinese Journal of Organic Chemistry》,Youji Huaxue)已从1999年第一期开始被ISI收入《Chemistry Citation Index》、《Science Citation IndexExpanded》。     

《March高等有机化学——反应、机理与结构(原著第7版)》

正该书是Michael B.Smith教授编著的《March's Advanced Organic Chemistry》第7版的中译本,是高等有机化学的经典教材。该书内容全面,条理清晰,通过有机化学日益发展的新方法、新技术系统地讲述有机化学的基本理论,并讲述如何运用新理论、新方法来解释有机化学反应中的新现象。书中根据反应类型给出了大量的反应并收集了大量的文献。     

《有机化学导论》简介

美国加里福尼亚大学Andrew Streitwieser,Jr.和Clayton H.Heatheoek所著《有机化学导论》(Introduction to Organic Chemistry)一书,自1976年初版以来,已经成为有机化学教学的重要参考书之一。1981年出版的第二版,既保持了第一版的特色,又在内容和编排上做了重要修改,使本书更便于教学,可作为我国有机化学基础课教学的英文参考书。     

基于雨课堂+企业微信+慕课的在线直播教学——以有机化学为例

主要介绍了基于雨课堂和企业微信双平台直播教学,以及同步慕课课程为辅的有机化学在线教学实践,并以教学实例展示了“学生为中心,教师为引导”的“疑探”式教学体系。该在线直播教学还融入以弹幕、微信群和小组作业为主的交互方式,注重学生与学生、学生与教师以及学生与教学资源的互动;通过构建多维度的考核体系,加强对学习过程的考核,提高学生学习的主动性和参与度。     

引进有机化学CAI软件试用报告

美国伊利诺大学(University of Illinois)用微电脑辅助有机化学教学已有十余年历史,该校Smith S.G.设计的《有机化学入门》(Introduction to Organic Chemistry)计算机辅助教学(Computer Assisted Instruction,简称CAI,下同)软件是世界上第一套专科水平的有机化学CAI软件。在美国被誉为最好的教学软件之一。截止1985年春,在美国已为千余所高级中学、专科和本科院校所采用。鉴于国内化学CAI软件不多,供有机     

对专章講授不饱和烃衍生物的一些体会

一在不少有机化学教科书中,把不飽和烴的衍生物(分子中除了重键以外还含有其他官能团的化合物)分散地附属于相应的烷烃衍生物之內。例如把不飽和烴的卤素衍生物放在卤代烷一章之末,把不飽和醛、酮和酸附属于醛、酮及羧酸各章,至于不飽和的醇,醚則多未提及。常見的教科书如1961年人民教育出版社出版高教用书編輯部組織选編的“有机化学”,南京大学主編的“有机化学”(1961年出版),吳懋仪編的“有机化学”,北京农业大学編的“有机化学教程”,以及Paul Karrar: "Lehrbuch Der Organischen Chemic"(1959年13版),L. Fisher and M. Fisher: "Organic Chemistry" (1957年第5版),等都是这样安排这一部分教材的。我們认为这样处理这一类化合物还有可以商榷的地方。     

评G.L.Patrick著Instant Notes in Organic Chemistry

G．L．Patrick著“Instant Notesin Organic Chemistry”一书是2000年由英国BIOS Scientific Publishers出版的Instant Notes系列参考书的一种。该书同年由科学出版社影印出版，中文译名为《精要速览系列有机化学(影印版)》。全书共315页，分十五章(Section)，每章又分若干分章。每     

有机化学在线课程建设*——基于“激越四段式”全在线教学模式

基于“激越四段式”全在线教学模式,以超星泛雅网络学习平台为课程建设平台,开展有机化学在线课程建设。每个单元由思维导图、引导案例、单元知识点、小组任务、知识拓展、单元作业等6个部分组成,各微知识点配备电子教材、微课视频、教学内容与讨论、知识点测验等4个板块。该在线课程可以满足学生多样化、层次化的个体和团队的自学需求,着重训练学生自主学习和探究性学习的能力。     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

N-Heterocyclic carbene-palladacyclic complexes: synthesis,characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%).     

Iodine-mediated oxidative Pictet-Spengler reaction using terminal alkyne as the 2-oxoaldehyde surrogate for the synthesis of 1-aroyl-β-carbolines and fused-nitrogen heterocycles

An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y₁ and Y₂. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones.     

Facile synthesis of bicyclic 1-arylpyrazol-5-ones

In this Letter, we described a facile method for constructing fused bicyclic 1-arylpyrazol-5-one ring system. We employed various methylene-containing carboxylic acids as the substrates and proved that the pyrazolone ring closure requires activated methylene group in intermediate II. Accordingly, a series of structurally diversified, fused bicyclic 1-arylpyrazol-5-ones was prepared in moderate to high yields using the requisite substrates.     

Synthesis of pyrrolo[1,2-a]pyrazines and pyrazino[1,2-a]indoles by Curtius reaction in Morita-Baylis-Hillman derivatives

Synthesis of substituted pyrrolo[1,2-a]pyrazines and pyrazino[1,2-a]indoles from the Morita-Baylis-Hillman derivatives of acrylates via saponification followed by Curtius reaction is described.     

正丁胺对激光染料荧光谱影响的研究

用正丁胺作为碳源,采用射频辉光放电制备碳膜,选用激光染料R6G和聚乙二醇混合液作为蒸气源,采用单源热蒸发,在蒸发室与染料同时沉积得到混合膜,用拉曼光谱和红外光谱分析了碳膜的结构和键合方式,分析表明:碳膜中存在胺基团和氢原子.混合膜的荧光谱测量结果表明,认为正丁胺对染料荧光谱的影响是因为胺基和氢原子的存在.     

Cu0-catalysed 1,3-dipolar cycloadditions of α-amino acid derived N,N-cyclic azomethine imines to ynones

A series of 20 CuAIAC reactions between eight 4-acylamino substituted pyrazolidine-3-one-1-azomethine imines and four terminal ynones were performed using Cu⁰ as catalyst. The corresponding fluorescent cycloadducts were obtained in very high yields upon simple workup. Thus, Cu-metal turned out to be a better catalyst than Cu^I in terms of yield and ease of isolation. Availability of azomethine imines, mild reaction conditions, and simple workup enable a “click” access to libraries of densely substituted 2,3-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-ones. Reactivity of differently substituted dipoles was evaluated experimentally and by quantum chemical methods (DFT).     

Synthesis and antioxidative/anti-inflammatory activity of novel fullerene–polyamine conjugates

(E)-4-(Fullerenopyrrolidin-1-yl)-3-methylbut-2-enoic acid and its corresponding succinimidyl ester, readily obtained through Prato-type modification of C₆₀, were used for the selective N-acylation of polyamines. The thus obtained conjugates were evaluated for their antioxidative and anti-inflammatory activity and their cytotoxicity was determined. Members of this family of compounds showed interesting anti-lipid peroxidation, anti-lipoxygenase and anti-inflammatory activity and comparable cytocompatibility to spermidine.