共查询到19条相似文献,搜索用时 125 毫秒
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1-脱氢松香酰基-3-取代硫脲以及5-(脱羧脱氢松香-4-基)-3-芳氨基- 1H-1,2,4-三唑化合物的合成与生物活性 总被引:2,自引:0,他引:2
以广西的优势资源松香为原料, 脱氢松香酸与亚硫酰氯、硫氰化钾分别在回流条件下反应6 h和1.5 h, 得到脱氢松香酰异硫氰酸酯, 产率52%; 然后与胺在加热回流条件下反应1.5 h, 得到11种1-脱氢松香酰基-3-取代硫脲4, 产率63%~94%; 4a~4f 分别与水合肼在搅拌下回流反应3~6 h, 得到6种5-(脱羧脱氢松香-4-基)-3-芳氨基-1H-1,2,4-三唑化合物5, 产率70%~94%; 所有化合物的结构均经IR, 1H NMR, 13C NMR和元素分析确认. 初步生物活性测试表明, 4e, 4f, 4j, 5b对枯草杆菌抑菌率较高, 特别是4j在浓度为50 mg/L时就达到较好效果; 4b, 4h, 4i, 5e在100 mg/L时对大肠杆菌的抑菌效果较好. 相似文献
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Yoshihiko Omura Eiko Renbutsu Minoru Morimoto Hiroyuki Saimoto Yoshihiro Shigemasa 《先进技术聚合物》2003,14(1):35-39
New chitosan derivatives are synthesized by the reductive N‐alkylation reaction of chitosan with various aldehydes, such as 2,4‐dihydroxybenzaldehyde, cholesteryl 4‐formylbenzoate, and N‐dehydroabietyl‐4‐formylbenzamide. The palladium‐adsorption ability of the newly synthesized derivatives is found to be as good as that of chitosan. A blend of chitosan and other biodegradable polymers is also found to exhibit palladium‐adsorption ability. In comparison to the starting chitosan, the chitosan derivative having dehydroabietyl‐type side chains exhibited an improved solubility in methanol. The chitosan derivatives are successfully applied as plastic coating materials for electroless plating. Copyright © 2003 John Wiley & Sons, Ltd. 相似文献
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A dehydroabietyl derivative 2 bearing a 2-(2'-hydroxyphenyl)benzimidazole unit was synthesized and its sensing behaviors toward metal ions were investigated by UV-Vis and fluorescence spectroscopy methods. In THF solution, compound 2 exhibited excellent selectivity for CuII over miscellaneous other metal ions including CrII, MnII, CoII, NiII, ZnII, CdII, AlIII, MgII, PbII, HgII, NaI, LiI and KI evidenced through the quenching of the fluorescence of the benzimidazole fragment. The reaction between 2 and Cu2+ was found to be stoichiometric with the formation of a 1:1 complex. 相似文献
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Takateru Kubota Chiyo Yamamoto Yoshio Okamoto 《Journal of polymer science. Part A, Polymer chemistry》2003,41(22):3703-3712
Polysaccharide-immobilized chiral stationary phases (CSPs) were prepared by the polymerization of cellulose 3,5-dimethylphenylcarbamate, having a polymerizable vinyl group, such as 4-vinylphenylcarbamate or 2-methacryloyloxyethylcarbamate, at the 6-position, with a vinyl monomer, such as styrene, isoprene, t-butyl acrylate, or t-butyl methacrylate, on silica gel under various conditions. Their chiral recognition abilities were then evaluated with high-performance liquid chromatography. The immobilized cellulose 3,5-dimethylphenylcarbamate remained on the silica gel even if washed with tetrahydrofuran, which could dissolve the cellulose derivative. The chiral recognition abilities of the immobilized CSPs were similar to those of the coated CSPs when the vinyl monomer content was low. The chiral recognition abilities of the obtained immobilized CSPs slightly depended on the vinyl monomers. The immobilization of the cellulose derivatives was more efficiently attained on the silica gel modified with a vinyl compound. The cellulose derivatives, randomly having a vinyl group at the 2-, 3-, or 6-position of the glucose unit, were prepared by a one-pot reaction. The immobilization efficiency of these derivatives was slightly lower than that of the derivative with the vinyl group at the 6-position. © 2003 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 41: 3703–3712, 2003 相似文献
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Merlino A Boiani M Cerecetto H González M 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2007,67(2):540-549
The spectroscopic behavior of 2-benzyl-2-methyl-2H-benzimidazole 1,3-dioxide derivatives in solution was studied in terms of electronic and nuclear magnetic resonance ((1)H and (13)C NMR) techniques. The experimental spectra were compared to the theoretical ones, obtained at DFT level, proving that the compounds adopt in solution a bird-like conformational distribution. Also, theoretically this conformational distribution resulted the most stable in gas phase. Infrared spectroscopy was used to study solid state behavior identifying experimentally the N-O stretching near to 1380, 1365 and 1225 cm(-1) and the vibrational benzimidazole skeleton near to 1610 and 1590 cm(-1). The vibrational spectrum was satisfactorily described by DFT calculations funding the N-O stretching as a coupled vibration near to 1470, 1350 and 1285 cm(-1). The fragmentation that takes place in mass spectrometry was assigned for all of the new derivatives. 相似文献
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由邻苯二胺合成苯并咪唑、喹喔啉以及1-H-2,3-二氢1,5-苯并氮杂卓 总被引:1,自引:0,他引:1
A series of benzo-fused heteroaromatic compounds with 5-, 6- and 7-membered tings, such as benzimidazole,quinoxaline and 1H-1,5-benzodiazepine derivatives, were synthesized through condensation reaction of o-pheny1-enediamine with ary1 aldehydes or ketones. The experimental conditions were carefully examined, and the products were characterized by ^1H NMR, ^13C NMR, MS, IR and elemental analyses. In addition, the structure of a benzodiazaepine derivative with 7-membered ring was confirmed by single crystal X-ray diffraction analysis. 相似文献
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通过糖单元6-位羟基的保护和去保护,运用区域选择性方法合成了6种新型多糖类氨基甲酸酯衍生物,分别为纤维素/直链淀粉-[2,3-二(3,5-二甲基苯基)-6-环己基]氨基甲酸酯、[2,3-二(3,5-二氯苯基)-6-环己基]氨基甲酸酯及[2,3-二(4-氯苯基)-6-环己基]氨基甲酸酯,并将其涂敷在氨丙基硅胶的表面制备HPLC手性固定相.利用1H-NMR与FTIR光谱技术对所合成衍生物进行结构表征和分析,并应用HPLC法评价其对于9种手性化合物的手性识别能力.通过与以手性识别能力高而著称且含有单一取代基的纤维素/直链淀粉-三(3,5-二甲基苯基氨基甲酸酯)等手性固定相的对比分析表明,所合成新型手性固定相对于某些对映体显示出更优的手性识别能力.由进一步分析表明,糖单元2-、3-和6-位取代基的性能对于纤维素和直链淀粉氨基甲酸酯类衍生物的手性识别能力均具有较大影响. 相似文献
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Novel C2-symmetric chiral 18-crown-6 derivatives with two aromatic sidearms 2-4 were prepared, and their enantiomeric recognition abilities as chiral NMR discriminating agents towards primary ammonium salts were examined. Among these chiral crown ethers, the most effective enantiomeric discrimination of racemic ammonium salts in the 1H NMR spectra was attained by the derivative with two pyrenylmethyl sidearms. 相似文献
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López-Rodríguez ML Benhamú B Murcia M Alvaro E Campillo M Pardo L 《Journal of computer-aided molecular design》2003,17(8):515-524
We report a structure-affinity analysis of an important element in the pharmacophore model for the recognition of 5-HT4 receptor antagonists: the voluminous substituent attached to the basic nitrogen of the ligand. We have designed, synthesized and pharmacologically evaluated a series of benzimidazole derivatives 1 containing a common molecular skeleton formed by N-[(4-piperidyl)methyl]-6-chlorobenzimidazole-4-carboxamide and four different substituents (R = butyl, 2-[(methylsulfonyl)amino]ethyl, 5-[(phenylacetyl)amino]pentyl, and 5-[(benzylsulfonyl)amino]pentyl). These compounds possess binding affinities in the nM range (Ki = 0.11-1.50 nM). Moreover, a ligand that contains a hydrogen atom attached to the basic nitrogen (R = H; Ki = 150 nM) is used as a control for structure-affinity relationships. 相似文献