“化学游戏教学”的“学教评产”混合式教学模式实践

基于师范类专业认证理念与毕业要求的教学前端分析,建构“学教评产”混合式教学模式,通过整合教学内容、重构教学安排与优化教学评价,对“化学游戏教学”课程进行创新性改革,并从学生学习成果、教学目标达成与学生满意度等3个方面评价教学成效。结果表明:该教学模式有助于学生学习成果质量的提升,能够有效促进教学目标的达成,并取得较高的学生满意度。     

混合式教学法在分析化学教学中的设计与实践*——以“碘量法”为例

针对中医药类专业中分析化学课堂以教为主、师生互动少、教学效果较差等问题,借鉴“线上线下(O2O)”混合教学模式,利用清华在线网络平台、雨课堂和中国MOOC等网络资源开展课程建设,并对分析化学课堂教学进行改革,重构教学理念和教学流程,“翻转”师生角色,将线上与线下教学有机统一,借助线上的网络学习资源、测试平台等帮助学生在时间和空间上自由学习,达到学生个性化、差异化学习的目的。     

“五位一体”混合式教学模式研究与实践*——以无机与分析化学课程为例

为解决无机与分析化学课程教学过程中面临的诸多现实问题,实现德育引领、能力培养、知识传授的教育教学目标,以学生的学习需求、学习能力、学习成效为中心,在线上与线下混合式教学的基础上,基于微课和翻转课堂,构建了“线上、线下、理论、实践、思政”有机融合的“五位一体”混合式教学新模式,对该教学模式的研究涵盖教学目标、教学内容、教学活动及学习效果评估等4个方面。经过2个学期的教学实践,结果表明,该教学模式提高了学生的学习主动性,收到了良好的学习效果。     

线上线下混合模式在药学专业分析化学教学中的应用*——以“酸碱滴定分析法”为例

以“酸碱滴定分析法”为例,依托自建药学专业SPOC课程资源,构建和实践了包含前端分析、教学过程和考核评价的线上线下混合教学模式。通过全面分析教学内容、教学目标、学情和学习环境等,设计了线上课前预习、线下课堂教学、线上课后拓展等3个步骤相衔接的教学过程,建立了线上线下相结合、突出过程性评价的综合考核方式。通过反思整个教学过程,对线上线下混合教学模式的主要优势和问题进行了讨论。     

“互联网+”背景下“无机及分析化学”课程教学策略与实践*

提出了“互联网+”背景下,“无机及分析化学”课程教学“一核心、二目标、三探索、四构建”的教学策略。实施结果表明,基于学生发展的课程核心知识,以“具有解决复杂制药工程、化工工程、材料工程的化学基础知识”“为学习后续课程打下坚实基础”2个具体教学目标为导向,通过开展综合实践活动、案例教学、课程思政等3种教学改革探索,构建线上线下有机衔接的立方书、立体化线上教学资源、线上线下混合型教学模式及过程和结果相融合的SPOC教学模式下的课程评价体系4种教学举措,能有效提高课程教学质量。     

基于“贯穿-翻转”混合式教学模式探索普通本科院校有机化学教学*

融合线下教育和线上平台教育,构建学生的认知脉络,使教学视角由教师转变为学生,从而激发学生的自主学习意识,加强教师与学生、学生与学生间的交流互动,提升教学效果。“贯穿-翻转”混合式教学模式通过留问题、查成效、齐互动、知识成脉络、测达标等5个步骤实施教学过程。     

“一体三翼”教学模式在工科无机化学教学中的应用与实践*

为适应当前复合型人才培养需求和提高学生自主学习能力和创新意识,在对大学一年级新生进行无机化学教学时需坚持以学生为主体的教学理念,并努力同时提高他们的思想政治素质、理论联系实际能力和科学研究素养。为此,提出“一体三翼”教学模式。然而,大多数工科院校无机化学课程的授课学时有所压缩,这对任课教师来讲是一种巨大挑战。通过“线上-线下”混合式教学解决学时不足问题,并通过学生课程参与度、学生学习成绩及教学反思等形式检验“一体三翼”教学模式的教学实践成效。     

深度学习视域下“线上线下”混合式教学模式应用实践*——以“无机与分析化学”课程为例

深度学习视域下“线上线下”混合式教学模式的核心是学生的深度参与、高级学习策略的使用及教师的优质讲授,最终实现学生深度学习能力的养成。“无机与分析化学”线上线下混合式教学通过在线预习、课堂讨论、课前课后测试、实践教学等多种教学设计,让学生化“被动”学习为“主动”学习,深度参与,锻炼学生自主学习能力,增强学生团队协作及解决复杂工程问题的能力,启发学生创新应用能力。     

线上线下互动教学模式在医学院校基础化学教学中的应用——以“缓冲溶液及其作用机制”为例

为提高基础化学的教学效果,以“UMU互动”为平台,开展线上线下混合式教学模式改革。以“缓冲溶液及其作用机制”教学设计为例, 阐述线上线下混合教学模式的应用。结果表明,混合式教学模式可以激发学生的学习兴趣,提升学生自主学习的能力,有效提高了教学质量和教学效果。     

“工程化学”SPOC的建设与教学效果

河西学院“工程化学”教师组建设了面向河西学院土木工程专业,1.5学分的“工程化学”SPOC(小规模限制性在线课程),录制了44个视频知识点,讲解了物质的化学组成与聚集状态、化学反应与能源、水溶液中的化学、非化工类生产中的化学知识,设置了11次作业强化学生学习效果。该课程通过超星学习通平台上线并完成了教学任务。通过3个专业班级的教学实践,发现线上视频学习、课后作业、线上教师答疑相结合的教学模式,不仅发挥了学生为主体的学习作用,还实现了良好的教学效果。     

A carbanion induced synthesis of highly congested pyrazole and imidazole containing heterocycles

An efficient approach to the synthesis of highly congested di, penta and hexacyclic pyrazoles as well as imidazole fragment containing novel heterocyclic molecule has been developed through a carbanion induced transformation of suitably functionalized 2H-pyran-2-ones, benzo[h]chromene and thiochromeno[4,3-b]pyrans. Due to the presence of fluorescence, we report their prime application metal sensor as off/on switching in ferric ions.     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

N-Heterocyclic carbene-palladacyclic complexes: synthesis,characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%).     

Selective synthesis of 4,5-dihydroimidazo- and imidazo[1,5-a]quinoxalines via modified Pictet–Spengler reaction

An efficient tandem approach for the selective synthesis of 4,5-dihydroimidazo[1,5-a]quinoxalines 6a–g and imidazo[1,5-a]quinoxalines 7a–h by the reaction of 2-imidazolyl anilines 4a–c with aryl aldehydes 5a–k under mild reaction conditions is described. Introduction of electron releasing alkyl groups in substrates 4a–b was found to be instrumental for the success of the reaction.     

Understanding the Diels-Alder reactivity of 1,2-azaborine analogues

The Diels-Alder reactivity of 1,2-heteroborines (H₄C₄B(H)X, X?=?NH, PH, AsH; O, S, Se) has been computationally explored by means of Density Functional Theory (DFT) calculations. The influence of the HB?=?X fragment on the reactivity of the system has been quantitatively analyzed in detail by means of the so-called Activation Strain Model (ASM) of reactivity. It is found that the interaction between these species and the dienophile is significantly stronger than that computed for their all-carbon isoelectronic counterpart, benzene. In addition, the strain energy plays a key role in the observed reactivity trends. The role of the aromaticity strength of these heteroarenes on the reactivity is also assessed.     

Synthesis of N-substituted carbazolones from α-iodo enaminones via Pd(0)-catalyzed intramolecular coupling under microwave irradiation

A variety of N-aryl and N-alkyl carbazolones were conveniently achieved in good to high yields via Pd₂(dba)₃-mediated intramolecular coupling of N-substituted α-iodo enaminones under microwave irradiation. The Pd(0)-catalyzed cyclization was found to proceed favorably with the more electron-deficient phenyl ring during the reactions involving unsymmetrical N,N-diaryl α-iodo enaminones. This unique property enables the construction of carbazolone skeleton containing nitro substituted benzenoid ring.     

Iodine-mediated oxidative Pictet-Spengler reaction using terminal alkyne as the 2-oxoaldehyde surrogate for the synthesis of 1-aroyl-β-carbolines and fused-nitrogen heterocycles

An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y₁ and Y₂. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones.     

Facile synthesis of bicyclic 1-arylpyrazol-5-ones

In this Letter, we described a facile method for constructing fused bicyclic 1-arylpyrazol-5-one ring system. We employed various methylene-containing carboxylic acids as the substrates and proved that the pyrazolone ring closure requires activated methylene group in intermediate II. Accordingly, a series of structurally diversified, fused bicyclic 1-arylpyrazol-5-ones was prepared in moderate to high yields using the requisite substrates.     

Synthesis of substituted 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles and 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles by intramolecular nitrilimine cycloaddition

Both substituted 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles and 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles have been synthesized by the 3+2 intramolecular dipolar cycloaddition of nitrilimines to alkynes. This cyclization has been extended to more versatile 3-bromo derivatives by the use of alkynylbromides as dipolarophiles.