共查询到19条相似文献,搜索用时 312 毫秒
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亲水性手性配体树脂对氨基酸的拆分 总被引:4,自引:0,他引:4
本文设计并合成了新型亲水性手性配体铜络合聚乙烯胺树脂,并以此树脂为高效液相色谱固定相,对一系列氨基酸进行了拆分研究,对拆分机理进行了探讨,并提出了合理的模型解释。 相似文献
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在参照文献基础上,合成并制备了直链淀粉,三(苯基氨基甲酸酯)手性固定相,利用高效液相色谱首次直接拆分了4种外消旋硫代缩水甘油醚,并考察了流动相中异丙醇含量对拆分的影响。 相似文献
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化学拆分的新方法研究 总被引:8,自引:0,他引:8
主要介绍了近年来发展起来的两种化学拆分新方法,包括拆分和组合拆分;并简要论述了化学拆分中的手性识别现象,以及化学拆分方法在手性药物制备中的应用。 相似文献
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直链淀粉手性固定相对8种外消旋硫代缩水甘油醚的直接拆分 总被引:11,自引:0,他引:11
利用高效液相色谱进行不对称拆分是十分有效的方法,其中多糖类手性固定相是非常重要的一种,它主要包括纤维素和淀粉两大类,Okamoto等[1~3]合成了大量的纤维素和直链淀粉的衍生物,并将其涂敷在大孔硅胶表面,从而制备了手性拆分能力较强的多种固定相,这类... 相似文献
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Han Xiaoqian Liu Yueqi Zhang Yuhua Zhang Weiqiang Li Yongmin Chen Liren 《Chromatographia》2002,56(5-6):319-322
Summary Amylose tris(phenylcarbamate) (ATPC) coated on a small particle silica gel was prepared. This ATPC chiral stationary phase
(ATPC-CSP) was found to be useful for the enantiomeric separation of some novel chiral tetrahedrane-type clusters. Moreover,
the influence of mobile phase modifier and of the structure of chiral tetrahedrane-type clusters on the chiral separation
and retention were investigated. The results suggest that not only the structure and concentration of alcohol in mobile phase,
but also the subtle structural differences in racemates can have a pronounced effect on enantiomeric separation and retention. 相似文献
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Cellulose tris(4-methylphenylcarbamate),amylose tris(3,5-dimethylphenylcarbamate) and amylose tris (phenylcarbamate) were prepared by the method reported by Okamoto and were coated onto an aminopropylated mesoporous spherical silica gel.These final products were used as chiral stationary phases of high performance liquid chromatography for the eighteen structurally related biphenyl compounds.The resolution was made using normal-phase methodology with a mobile phase consisting of n-hexane-alcohol(ethanol,1-propanol,2-propanol or 1-butanol).The effects of various aliphatic alcohols in the mobile phase were studied.The structural features of the solutes that influence their k′ were discussed.A dominant effects of trifluoroacetic acid on chiral separation of acidic solutes was noted. 相似文献
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Xiao Qian HAN Yong Min LI Yu Hua ZHANG Sheng Xiang JIANG Li Ren CHEN* Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 《中国化学快报》2002,13(12)
Optical resolution using high performance liquid chromatography chiral stationary phases has been widely used in many modern research fields such as asymmetric synthesis, asymmetric catalytic and separation of racemic pharmaceuticals. In the past years, various chiral stationary phases have been developed and have been commercially available1. Among them, polysaccharide based phases are the widely used CSPs. A wide variety of enantiomeric compounds including chiral aromatic alcohols, enant… 相似文献