| 支链淀粉-三(苯基氨基甲酸酯)手性固定相的制备及对外消旋化合物的直接拆分 |
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| 引用本文： | 周志强,候经国,陈立仁.支链淀粉-三(苯基氨基甲酸酯)手性固定相的制备及对外消旋化合物的直接拆分[J].分子催化,1997(6). |
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| 作者姓名： | 周志强 候经国 陈立仁 |
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| 作者单位： | 中国科学院兰州化学物理研究所 |
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| 基金项目： | 中国科学院重点项目基金 |
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| 摘 要： | 支链淀粉－三（苯基氨基甲酸酯）手性固定相的制备及对外消旋化合物的直接拆分１）周志强候经国陈立仁２）（中国科学院兰州化学物理研究所兰州７３００００）关键词高效液相色谱支链淀粉－三（苯基氨基甲酸酯）外消旋化合物手性拆分分类号Ｏ６５７．７在大量的手性固定相...
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| 关 键 词： | 高效液相色谱 支链淀粉－三（苯基氨基甲酸酯） 外消旋化合物 手性拆分 |
Direct Enantiomeric Resolution of Racemic Compounds by HPLC Using Amylopectin Tris(Phenylcarbamate) Chiral Stationary Phase |
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| ZHOU Zhiqiang,HOU Jingguo,CHEN Liren.Direct Enantiomeric Resolution of Racemic Compounds by HPLC Using Amylopectin Tris(Phenylcarbamate) Chiral Stationary Phase[J].Journal of Molecular Catalysis (China),1997(6). |
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| Authors: | ZHOU Zhiqiang HOU Jingguo CHEN Liren |
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| Institution: | Lanzhou Institute of Chemical Physics The Chinese Academy of Sciences Lanzhou 730000 |
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| Abstract: | In present study, amylopectin tris(phenylcarbamate) was synthesized, and used as chiral stationary phase on silica gel. This stationary phase offered a practically useful chiral column with high enantiomer separability. Amylopectin was allowed to react with an excess of phenylisocyanate in pyridine for 48 h. The obtained carbamates were dissolved in THF and adsorbed on silica gel which has been treated with 3 aminopropyltriethoxysilane. The weight ratio of the carbamate to the silica gel was 0.45/2.55. One cyclic ketone, one cyclic alcohol and two acidic drugs were resoluted on amylopectin tris(phenylcarbamate) chiral stationary phase. Separation was carried out with a hexane/2 propanol mixture at a flow rate of 0.5 mL/min at room temperature. The effects of 2 propanol concentration on the retention and resolution had been investigated. |
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| Keywords: | HPLC Amylopectin tris(phenylcarbamate) Racemic compounds Enantiomeric separation |
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