抗肿瘤药双萘酰亚胺的研究进展

DNA嵌入剂双萘酰亚胺是一种新型的抗肿瘤药物。从它的合成方法、结构与性质的关系以及与DNA的相互作用等方面综述了抗肿瘤药物双萘酰亚胺的研究进展。     

含萘酰亚胺基树枝状化合物的研究进展

含萘酰亚胺基的树枝状化合物具有特殊的发光性能和电学性质,其中一个重要特征是它还具有优异的光诱导电子转移性能,从而引起了人们的广泛关注.近年来科学家们已经合成了多种新型的含萘酰亚胺基树枝状化合物,它们在众多领域具有潜在的应用价值.综述了近年来含萘酰亚胺基的树枝状化合物的研究进展,介绍了部分树枝状萘酰亚胺基化合物的合成及其应用,这些化合物由于其独特的结构特点而具有特殊的性能,在化学传感器、光捕获天线材料、有机电致发光器件、药物传输、环境污染检测等领域具有重要的应用价值.最后,展望了此类化合物良好的应用前景.     

新型含两个西佛碱单元的1，8-萘酰亚胺衍生物的合成及其光学性能

以4-溴-1,8-萘酐和取代醛为起始原料,合成了一系列新颖的含两个西佛碱单元的1,8-萘酰亚胺衍生物--双芳香醛缩N-氨基4-肼基-1,8-萘酰亚胺(5a～51),其结构经1H NMR,IR和元素分析确证.研究了5在乙腈中的紫外-可见和荧光发射光谱.结果表明5在520 nm～570nm内发光.     

含萘酰亚胺光功能基元的吡唑啉酮席夫碱的合成及其光谱性质

以4-溴-1,8-萘酐为原料,经亚胺化、取代和还原反应合成了中间体N-对氨基苯基-4-哌啶-1,8-萘酰亚胺(4),4与1-苯基-3-甲基-4-苯甲酰基-吡唑啉酮-5缩合得到一种含萘酰亚胺光功能基元的的新型吡唑啉酮席夫碱——1-苯基-3-甲基-4-苯甲酰基-吡唑啉酮-5缩N-对氨基苯基-4-哌啶-1,8-萘酰亚胺(6)。4和6的结构经1H NMR和IR确证。研究了6在不同溶剂中的光谱性质,发现其吸收光谱和荧光光谱随溶剂的极性不同而表现出不同的光谱特性。进一步研究表明6在不同溶剂中可能以不同的互变异构体存在。     

含氨基萘酰亚胺类DNA嵌入剂切割质粒DNA

合成了一系列含氨基的萘酰亚胺类化合物以开发新型的DNA切割剂。琼脂糖电泳分析表明,100μmol/L含氨基萘酰亚胺化合物在70℃、pH7·5的条件下能有效切割超螺旋质粒DNA,而且切割产物均为接近原质粒大小一半的DNA线性片段。     

含有萘酰亚胺单元的铕配合物合成及其发光性能研究

通过在邻菲啉中性配体上引入萘酰亚胺发色团,合成了新型含有萘酰亚胺单元的铕配合物Eu(DBM)3(PNI-phen).通过控制激发,可以得到具有萘酰亚胺和Eu³⁺特征发射的荧光光谱.通过荧光光谱和激发光谱研究了铕配合物的能量传递及发光机制.     

新型萘酰亚胺衍生物的合成

N-(N’,N’-二甲基氨基乙基)-4-硝基-1,8-萘酰亚胺和2,3-二甲基苯并噻唑碘化盐在痕量水存在下经亲核取代反应合成了一个新型的萘酰亚胺衍生物——N-(N’,N’-二甲基氨基乙基)-4-[2-(2,3-二氢-2,3-二甲基苯并噻唑)氧基]-1,8-萘酰亚胺,其结构经1H NMR,13C NMR和ESI-MS表征。并对反应机理进行了初步研究。     

含杂萘联苯结构聚醚酰亚胺共聚物的物理性能

二氮杂萘酮;含杂萘联苯结构聚醚酰亚胺共聚物的物理性能     

聚萘酰亚胺膜的制备及其气体分离性能

利用萘二酐与邻位含脂肪族取代基的芳香二胺聚合制备了一系列均聚及共聚萘酰亚胺。这些C—N键邻位含取代基的聚萘酰亚胺可溶解于有机溶剂中并具有良好的成膜性。这些膜的拉伸强度在54~77 MPa之间,断裂伸长率在6.4%~8.1%,杨氏模量在1.3~2.2 GPa。这些聚萘酰亚胺具有优异的热稳定性,热分解温度在448~501℃范围内,玻璃化转变温度在382~391℃范围内。气体分离性能测试结果表明,聚萘酰亚胺具有突出的CO_2/CH_4分离能力,CO_2气体透过系数在37.2~151 barrer范围内,而CO_2/CH_4的选择系数在20.9~31.7的范围内,这表明了制备的聚萘酰亚胺气体分离膜材料在天然气纯化方面具有潜在的应用价值。     

水溶性1，8-萘酰亚胺衍生物的合成及其对有机溶剂中少量水的识别

萘二甲酸酐与2-(2-氨乙基氨基)乙醇在乙醇中反应合成了一种新型水溶性1,8-萘酰亚胺衍生物--N-[2-(2-羟乙基氨基)-乙基]-1,8-萘酰亚胺(3),其结构经1H NMR,IR,MS和元素分析表征.荧光光谱分析发现3在不同溶剂中具有不同的荧光性质,在非(或弱)极性-非质子性溶剂、极性-非质子溶剂中几乎不产生或产生较弱的荧光,而在极性-质子性溶剂中产生较强的荧光,在水中的荧光最强.这种特性使3有望用于识别有机溶剂中的少量水.     

电化学阴极沉积制备氧化镍/碳纳米管复合电极的准电容特性

A novel type of composite electrode based on multiwalled carbon nanotubes coated with nano nickel oxide particles has been used in supercapacitors. Nickel oxide cathodically deposited from Ni(NO3)2 solution with carbon nanotubes as the matrix exhibited large pseudocapacitance of 25F/g in 6 mol/L KOH. The morphology of composites was examined by scanning electron microscope (SEM). To characterize the CNTs/nickel oxide composite electrode, a charge discharge cycling test for measuring specific capacitance, cyclic voltammetry, and ac impedance test is executed. The nickel oxide composite exhibiting excellent pseudocapacitive behavior(i.e.high reversibility, high specific capacitance, and low self discharge rate) has been demonstrated to be a potential candidate for the application of electrochemical supercapacitors.     

Polyamide-11/lead zirconate titanates—a novel composite material with high dielectric properties

Polymeric composites gain increasing interest in materials research and practice applications due to combining excellent electric property of piezoelectric ceramic and flexibility of polymer matrix. A novel decoupling capacitor with high dielectric constant has been developed by mixing polyamide-11 (PA11) with ferroelectric ceramic lead zirconate titanates (PZT). The composite demonstrates high dielectric constant, with better frequency stability and low dielectric losses. The dependence of the dielectric constant on frequency and polymer fraction was investigated. The excellent dielectric constant of 100 and the dielectric loss of 0.1 can be obtained at a PA11 volume fraction of 0.4. The enhanced dielectric behavior originates from good connection between ferroelectric ceramic and PA11 Dielectric losses of the PZT/PA11 composites change slightly with the test frequency. Our findings suggest that the created polymeric composites with relatively high dielectric constant represent a novel type of material that is flexible and easy to process. Moreover, is suited to applications in advanced decoupling capacitors and flexible electronics.     

新型聚苯并咪唑树脂的微波合成及质子交换膜的性能

采用微波合成法, 调整己二酸和2,6-吡啶二甲酸2种二酸单体的配比, 使其与联苯四胺进行三元共聚, 制备出一系列新型含脂肪链结构的聚苯并咪唑(PBI)类质子交换膜, 并用红外光谱、 热重分析进行了表征, 对膜的吸水率、 溶胀率、 质子传导率、 机械强度及抗氧化性能等进行了测试. 当己二酸与2,6-吡啶二甲酸的摩尔比为3: 2时, 所制备的PBI-C₂膜掺杂磷酸后在160℃下的质子传导率可达30 mS/cm, 拉伸强度在常温下可达77.54 MPa, 断裂伸长率为39.25%, 最大储能模量为9.0623 MPa, 最大损耗模量为8.36 MPa, 玻璃化转变温度为360℃, 芬顿试验192 h后膜的降解率仅为0.21%, 表明PBI-C₂膜在高温质子交换膜燃料电池中具有较好的应用前景.     

Synthesis of a novel phosphate‐containing highly transparent PMMA copolymer with enhanced thermal and flame retardant properties

A novel poly(methyl methacrylate) (PMMA)‐based copolymer (PMMA‐co‐BDPA) rich in aromatic rings was synthesized via radical copolymerization between a phosphorus‐containing acrylic monomer (BDPA) and methyl methacrylate (MMA). UV‐vis spectroscopy demonstrated that the copolymer had high transparency. Thermogravimetric analysis (TGA) and a differential scanning calorimeter (DSC) were used to test the thermal properties of the composites. Additionally, the PMMA‐co‐BDPA‐15 copolymer exhibited a 23% increase in the limited oxygen index (LOI) value. A cone calorimeter test indicated that the peak heat release rate (pk‐HRR) of PMMA‐co‐BDPA was reduced by 29.2% compared with that of pure PMMA, and the carbon yield of burning was obviously increased. The combined test results demonstrated that the prepared copolymer material had good transparency, thermal stability, and flame retardancy.     

Anti-diabetes effect of Zn(II)/carnitine complex by oral administration

A novel bis(L-carnitinato)Zn(II) complex, Zn(car)(2)Cl(2), was prepared, and its insulinomimetic and antidiabetic activities were examined. The complex showed a tendency to lower the high blood glucose levels of KK-A(y) mice with type 2 diabetes mellitus when given by oral administration at a dose of 20 mg Zn/kg body weight for 16 d. In addition, the complex improved glucose tolerance ability when examined by the oral glucose tolerance test (1 g glucose/kg body weight).     

用于现场FTIR及UV/Vis光谱电化学的高质量简单结构的光透薄层电化学池

设计制作了一种应用于紫外可见、红外电谱电化学的新型光透薄层电化学池(OTTLE),并以铁氰化钾水溶液、二茂铁乙腈溶液体系进行了表征。池腔几何结构的合理设计使电位降和边缘效应降至最低。该池有良好的伏安响应特性并可用它得到高质量的UV/Vis和IR光谱。由于简单的结构及低廉的造价使适用于光谱电化学研究的电化学池变得更容易得到。     

Activity-guided isolation of saponins from Kalopanax pictus with anti-inflammatory activity

By bioassay-guided separation, a known saponin, kalopanaxsaponin A (1) and a new saponin, pictoside A (2) were isolated from the stem bark of Kalopanax pictus as anti-inflammatory components when evaluated by vascular permeability test. Another novel saponin, pictoside B (3) was also isolated but was inactive in the test system used. The structures of pictosides A and B were elucidated as caulophyllogenin 3-O-alpha-L-rhamnopyranosyl(1-->2)-alpha-L-arabinopyranoside (2) and pictogenin (3beta,6beta,16alpha,23-tetrahydroxyolean-12-ene-28-oic acid) 3-O-alpha-L-arabinopyranoside (3), respectively, by spectral analysis and by chemical degradation. Kalopanaxsaponin A and pictoside A showed significant anti-inflammatory activity at the oral doses of 50 mg/kg.     

Instrumental intelligent test of food sensory quality as mimic of human panel test combining multiple cross-perception sensors and data fusion

Instrumental test of food quality using perception sensors instead of human panel test is attracting massive attention recently. A novel cross-perception multi-sensors data fusion imitating multiple mammal perception was proposed for the instrumental test in this work. First, three mimic sensors of electronic eye, electronic nose and electronic tongue were used in sequence for data acquisition of rice wine samples. Then all data from the three different sensors were preprocessed and merged. Next, three cross-perception variables i.e., color, aroma and taste, were constructed using principal components analysis (PCA) and multiple linear regression (MLR) which were used as the input of models. MLR, back-propagation artificial neural network (BPANN) and support vector machine (SVM) were comparatively used for modeling, and the instrumental test was achieved for the comprehensive quality of samples. Results showed the proposed cross-perception multi-sensors data fusion presented obvious superiority to the traditional data fusion methodologies, also achieved a high correlation coefficient (>90%) with the human panel test results. This work demonstrated that the instrumental test based on the cross-perception multi-sensors data fusion can actually mimic the human test behavior, therefore is of great significance to ensure the quality of products and decrease the loss of the manufacturers.     

分散液-液微萃取快速、直接测定有机化合物lgP值

用3-氯丙基三甲氧基硅烷对Fe₃O₄纳米球的表面进行改性, 制得表面疏水的Fe₃O₄/SiCH₂CH₃Cl纳米球. 将Fe₃O₄/SiCH₂CH₃Cl纳米球均匀预分散在正辛醇中, 利用分散液-液微萃取建立了快速、 直接测定有机化合物lgP值的新方法. 待测有机化合物可在3 min内在两相达到分配平衡, 通过磁铁吸引含有Fe₃O₄/SiCH₂CH₃Cl纳米球的正辛醇小液滴, 可实现两相快速完全分离. 在萃取过程中, 由于Fe₃O₄/SiCH₂CH₃Cl纳米球被正辛醇包围, 失去对待测化合物的吸附能力, 因此Fe₃O₄/SiCH₂CH₃Cl纳米球对测定有机化合物分配平衡的影响很小. 通过该方法测定了14种不同有机化合物的lgP值, 结果均与文献报道一致. 与其它直接测定方法相比, 该方法快速、 准确、 简单且样品消耗少.