基于翻转课堂-PBL的混合式“金课”教学*——以“药物分析”为例

以创新应用能力及岗位需求重构课程标准,更新教学方法和教学手段,从教学设计、教学实施、教学评价、教学效果等4个方面系统地探索了基于翻转课堂-PBL教学的药物分析课程教学模式建设与应用,旨在形成多元化、多层次的药物分析教学新体系,将“以教师教为主”的教学模式转变为“以学生学为主”,让学生化“被动”为“主动”学习,锻炼学生自主学习能力,增强学生团队协作及分析解决问题的能力,启发学生创新应用能力。     

“原子吸收分光光度法测玩具表面涂层中铅”信息化项目教学的设计与实施

以"原子吸收分光光度法测定玩具表面涂层中铅"为例,将信息化技术和资源应用于课堂,构建了一种"信息化、项目教学、以学生为中心"的教学模式,从教学分析、教'学策略选择、教学组织、教学效果等4个方面来优化教学内容与教学活动。实践表明,信息化项目教学模式的运用,能将晦涩难理解的原理形象化,调动学生学习的主动性,丰富了传统教学方式,提升了教学效果。     

高职“仪器分析及实验”循环进阶教学模式的开发与应用

通过分析"仪器分析"教学内容及教学对象的特点,针对"仪器分析"课程传统教学方法存在的弊端进行改革。从教学体系、教学内容、教学方法等多方面设计"仪器分析及实验"课程,构建出以学生为主体、基于认知规律、多层次阶梯式的教学模式,以提升学生对仪器分析方法的实际应用能力。     

基于创新性应用型人才培养的《材料物理》教学改革与实践

为突出学生学习能力、应用能力和创新能力培养,对《材料物理》课程的教学内容与设计、教学方式、考核形式与评价方法等方面进行了改革。构建了科学合理的教学内容,创建并实践了基于功能材料设计思路的教学设计,辅以"翻转课堂"教学方式改革,结合开放式作业改革与评价方法创新,形成了适合于创新性应用型人才培养的《材料物理》课程教学模式,促进了学生学习能力、应用能力、创新能力和综合素质的提高,实现了学生"知识-能力-素质"层层推进式的培养格局。     

《聚合物合成工艺学》教学中的方法研究与改革

《聚合物合成工艺学》是高分子材料与工程专业中的必修专业课程,其教学目的不仅仅是传授高分子合成过程中的基础知识,更应该培养学生独立思考能力,应用所学的知识去分析问题、解决问题,为今后的工作中遇到的困难和问题提供学习方法和思路。本文针对《聚合物合成工艺学》课程的特点及本校培养新世纪"职业化学工程师"的教学指导方针,对如何提高学生兴趣、提高教学质量及培养学生的工程实践能力,在教学内容、教学方法等方面提出了一些方法见解和改革。     

以“学生为中心”的研究生波谱分析课程教学改革与实践

通过分析美国威斯康星大学-麦迪逊分校研究生波谱分析课程的教学理念、教学内容、教学方法和评价体系的特点,并结合自身的教学实际,提出我校的课程改革应在"以学生为中心"的教学理念指导下,优化教学内容,改革教学方法和评价体系,逐步建立基于"知识+能力+素养"的人才培养模式。经过两个学年的教学实践证明,以"学生为中心"的教学模式是提高教学效果的一个有效途径。     

“五位一体”混合式教学模式研究与实践*——以无机与分析化学课程为例

为解决无机与分析化学课程教学过程中面临的诸多现实问题,实现德育引领、能力培养、知识传授的教育教学目标,以学生的学习需求、学习能力、学习成效为中心,在线上与线下混合式教学的基础上,基于微课和翻转课堂,构建了“线上、线下、理论、实践、思政”有机融合的“五位一体”混合式教学新模式,对该教学模式的研究涵盖教学目标、教学内容、教学活动及学习效果评估等4个方面。经过2个学期的教学实践,结果表明,该教学模式提高了学生的学习主动性,收到了良好的学习效果。     

基于高效教学的医学基础化学教学模式改革实践

针对医学基础化学教学过程中存在的问题,基于"以学生为中心""以产出为导向"的教学理念,围绕培养目标和毕业要求,从课程内容组织、教学内容更新、教学模式改革等方面进行了系统设计和实践,注重教学内容与医学知识的融合,充分调动了学生学习的主动性和积极性,提高了学生的科学素养和发展能力,以更好地服务于高素质领军型医学人才的培养。     

《植物纤维化学》中的天然高分子教学的改革实践

天然高分子作为一种资源,由于它们来源丰富且可再生利用,越来越显示出其重要地位.本文介绍了作者将培养学生的创新能力理念贯穿于教学实践中,对天然高分子教学实践采取了一些改革措施.以纤维素、木质素及半纤维素的结构-性质及其相互关系为主线展开教学内容,加强学生的高分子理论的基础知识,培养高素质的科学技术人才;选修课以研究式教学为主,加强培养学生自学能力和创新理念.改革教学模式,在教学过程中提高学生的学习兴趣,加强"教"与"学"的互动,提倡科学的批评精神,培养创新精神,以达到良好的教学目的.     

无机及分析化学实验课“双轨型”教学模式改革与探索

针对无机及分析化学实验教学中存在的问题,探索"课内"实验与"课外"实践相结合的"双轨型"教学模式。介绍了"双轨型"实践教学模式改革的重要性、总体目标和架构;从改革教学方法、优化教学内容、倡导"绿色"化学等方面对"课内"实验教学进行改革;从教学内容、方法与组织等方面对"课外"实践教学进行探索;并对"双轨型"实践教学考核评价体系进行了优化,取得了较好的成效。     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

N-Heterocyclic carbene-palladacyclic complexes: synthesis,characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%).     

Iodine-mediated oxidative Pictet-Spengler reaction using terminal alkyne as the 2-oxoaldehyde surrogate for the synthesis of 1-aroyl-β-carbolines and fused-nitrogen heterocycles

An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y₁ and Y₂. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones.     

Facile synthesis of bicyclic 1-arylpyrazol-5-ones

In this Letter, we described a facile method for constructing fused bicyclic 1-arylpyrazol-5-one ring system. We employed various methylene-containing carboxylic acids as the substrates and proved that the pyrazolone ring closure requires activated methylene group in intermediate II. Accordingly, a series of structurally diversified, fused bicyclic 1-arylpyrazol-5-ones was prepared in moderate to high yields using the requisite substrates.     

Synthesis of pyrrolo[1,2-a]pyrazines and pyrazino[1,2-a]indoles by Curtius reaction in Morita-Baylis-Hillman derivatives

Synthesis of substituted pyrrolo[1,2-a]pyrazines and pyrazino[1,2-a]indoles from the Morita-Baylis-Hillman derivatives of acrylates via saponification followed by Curtius reaction is described.     

正丁胺对激光染料荧光谱影响的研究

用正丁胺作为碳源,采用射频辉光放电制备碳膜,选用激光染料R6G和聚乙二醇混合液作为蒸气源,采用单源热蒸发,在蒸发室与染料同时沉积得到混合膜,用拉曼光谱和红外光谱分析了碳膜的结构和键合方式,分析表明:碳膜中存在胺基团和氢原子.混合膜的荧光谱测量结果表明,认为正丁胺对染料荧光谱的影响是因为胺基和氢原子的存在.     

Cu0-catalysed 1,3-dipolar cycloadditions of α-amino acid derived N,N-cyclic azomethine imines to ynones

A series of 20 CuAIAC reactions between eight 4-acylamino substituted pyrazolidine-3-one-1-azomethine imines and four terminal ynones were performed using Cu⁰ as catalyst. The corresponding fluorescent cycloadducts were obtained in very high yields upon simple workup. Thus, Cu-metal turned out to be a better catalyst than Cu^I in terms of yield and ease of isolation. Availability of azomethine imines, mild reaction conditions, and simple workup enable a “click” access to libraries of densely substituted 2,3-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-ones. Reactivity of differently substituted dipoles was evaluated experimentally and by quantum chemical methods (DFT).     

Synthesis and antioxidative/anti-inflammatory activity of novel fullerene–polyamine conjugates

(E)-4-(Fullerenopyrrolidin-1-yl)-3-methylbut-2-enoic acid and its corresponding succinimidyl ester, readily obtained through Prato-type modification of C₆₀, were used for the selective N-acylation of polyamines. The thus obtained conjugates were evaluated for their antioxidative and anti-inflammatory activity and their cytotoxicity was determined. Members of this family of compounds showed interesting anti-lipid peroxidation, anti-lipoxygenase and anti-inflammatory activity and comparable cytocompatibility to spermidine.