共查询到20条相似文献,搜索用时 31 毫秒
1.
Matysiak S Montesi A Pasquali M Kolomeisky AB Clementi C 《Physical review letters》2006,96(11):118103
The dynamics of translocation of polymer molecules through nanopores is investigated via molecular dynamics. We find that an off-lattice minimalist model of the system is sufficient to reproduce quantitatively all the experimentally observed trends and scaling behavior. Specifically, simulations show (i) two translocation regimes depending on the ratio of pore and polymer length, (ii) two different regimes for the probability of translocation depending on applied voltage, (iii) an exponential dependence of translocation velocity upon applied voltage, and (iv) an exponential decrease of the translocation time with temperature. We also propose a simple theoretical explanation of each of the observed trends within a free energy landscape framework. 相似文献
2.
The effects of an attractive wall at the trans side on the translocation of an eight-site bond-fluctuation model (BFM) polymer through a pore in a membrane under driving are simulated by the dynamic Monte Carlo method. The attractive wall shows two contrary effects: its excluded volume effect reduces configuration entropy and thus hinders the translocation of the polymer, while its attraction decreases the energy and thus accelerates the translocation. At a critical polymer-wall interaction ε*?≈-?1, we find that the two effects compensate each other and the translocation time τ is roughly independent of the separation distance between the wall and the pore. The value ε*?≈-?1 is roughly equal to the critical adsorption point for the BFM polymer. Moreover, the value of the critical attraction is roughly independent of chain length N and chemical potential difference Δμ. At last, a scaling relation τ?~?N(α) is observed for polymer translocation at a high value of NΔμ. Though the translocation time is highly dependent on the polymer-wall interaction and pore-wall separation distance, the exponent α is always about 1.30?±?0.05 so long as NΔμ is large enough. 相似文献
3.
Brun L Pastoriza-Gallego M Oukhaled G Mathé J Bacri L Auvray L Pelta J 《Physical review letters》2008,100(15):158302
We study the transport of dextran sulfate through a protein channel as a function of applied voltage. Below 60 mV, the chain's entrance to the pore is hindered by an entropic barrier; above 60 mV, the strong local electric field forces the chain entrance. The effective charge of the polyelectrolyte inside the pore is reduced. We observe two types of blockades which have durations that decrease when the applied voltage increases. The shortest is a straddling time between the polyelectrolyte and the pore; the longest is the translocation time. The translocation time obeys an exponential dependence upon applied voltage. 相似文献
4.
This paper theoretically studies the free energy and conformational entropy of a long
polymer threading a long nanopore (n0/N \ge 0.1) on external electric
field. The polymer expanded model is built in this paper, that is, a
single long polymer chain with N monomers (each of size a) threading
a pore
with n0 monomers can be regarded as polymer with N+n_{0} monomers
translocating a 2-dimension hole embedded in membrane. A theoretical
approach is presented which explicitly takes into account the nucleation
theory. Our calculations imply that, the structure of polymer changes
more acutely than other situation, while its leading monomer reaches the second
vacuum and its end monomer escapes the first vacuum. And it is also shown
that the length scale of polymer and pore play a very important role for
polymer translocation dynamics. The present model predicts that the
translocation time depends on the chemical potential gradient and the
property of the solvent on sides of pore to some extent. 相似文献
5.
We study the effect of the crowded environments on the translocation of a polymer through a pore in a membrane. By systematically treating the entropic penalty due to crowding, we show that the translocation dynamics are significantly altered, leading to novel scaling behaviors of the translocation time. We also observe new and qualitatively different translocation regimes depending upon the extent of crowding, transmembrane chemical potential asymmetry, and polymer length. 相似文献
6.
Davide Valenti Giovanni Denaro Dominique Persano Adorno Nicola Pizzolato Salvatore Zammito Bernardo Spagnolo 《Central European Journal of Physics》2012,10(3):560-567
Polymer translocation through the nanochannel is studied by means of a Monte Carlo approach, in the presence of a static or
oscillating external electric voltage. The polymer is described as a chain molecule according to the two-dimensional “bond
fluctuation model”. It moves through a piecewise linear channel, which mimics a nanopore in a biological membrane. The monomers
of the chain interact with the walls of the channel, modelled as a reflecting barrier. We analyze the polymer dynamics, concentrating
on the translocation time through the channel, when an external electric field is applied. By introducing a source of coloured
noise, we analyze the effect of correlated random fluctuations on the polymer translocation dynamics. 相似文献
7.
We study the translocation process of a polymer in the absence of external fields for various pore diameters b and membrane thickness L. The polymer performs Rouse and reptation dynamics. The mean translocation time (tau(t)) that the polymer needs to escape from a cell and the mean dwell time (tau(d)) that the polymer spends in the pore during the translocation process obey scaling relations in terms of the polymer length N, L, and b/R(g), where R(g) is the radius of gyration for the polymer. We explain these relations using simple arguments based on polymer dynamics and the equilibrium properties of polymers. 相似文献
8.
Viorel P. Paun 《Central European Journal of Physics》2009,7(3):607-613
In this paper the driven transport of linear polymers through a nanopore is presented. Biopolymer physical behavior in an
external electric field is modeled and its motion is simulated using the Langevin impulse integrator method. Within fairly
large limits, the polymer translocation time is inversely proportional with the electric field intensity and directly proportional
with the polymer chain length.
相似文献
9.
Influence of polymer-pore interactions on translocation 总被引:1,自引:0,他引:1
We investigate the influence of polymer-pore interactions on the translocation dynamics using Langevin dynamics simulations. An attractive interaction can greatly improve the translocation probability. At the same time, it also increases the translocation time slowly for a weak attraction while an exponential dependence is observed for a strong attraction. For fixed driving force and chain length the histogram of translocation time has a transition from Gaussian distribution to long-tailed distribution with increasing attraction. Under a weak driving force and a strong attractive force, both the translocation time and the residence time in the pore show a nonmonotonic behavior as a function of the chain length. Our simulations results are in good agreement with recent experimental data. 相似文献
10.
《Physica A》2005,350(1):95-107
The driven translocation dynamics of a polynucleotide chain through a nanopore is studied using off-lattice Monte-Carlo simulations, which plays an important role in the nanopore sequencing of polynucleotides. We report a detailed study on the dependence of translocation dynamics on the chain length and the local geometry near the nanopore. In particular, we find that the length dependence of the infection time of the chain could exhibit very different behaviors for different geometries. 相似文献
11.
The translocation of polymer chain through a small pore from a high concentration side (cis side) to a low concentration side (trans side) is simulated by using Monte Carlo technique. The effect of the polymer--pore interaction on the translocation is studied. We find a special interaction at which the decay of the number of polymer chain, N, at the cis side obeys Fick's law, i.e. N decreases exponentially with time. The behaviour is analogous to the diffusion of hard sphere. 相似文献
12.
13.
14.
基于紧束缚的Su-Schrieffer-Heeger模型,利用非绝热的动力学方法,研究了金属/聚合物/金属三明治结构中载流子注入与输运的动力学过程,其中,聚合物中含有一个掺杂离子. 电子波函数随时间的演化满足含时Schrdinger方程,晶格运动满足经典的牛顿运动方程. 研究发现,掺杂离子对注入到聚合物中的载流子的作用类似一个控制阀门,阀门的状态与电场的强度和偏压的大小密切相关.
关键词:
载流子输运
波包
非绝热动力学 相似文献
15.
The detection of linear polymers translocating through a nanoscopic pore is a promising idea for the development of new DNA
analysis techniques. However, the physics of constrained macromolecules and the fluid that surrounds them at the nanoscopic
scale is still not well understood. In fact, many theoretical models of polymer translocation neglect both excluded-volume
and hydrodynamic effects. We use Molecular Dynamics simulations with explicit solvent to study the impact of hydrodynamic
interactions on the translocation time of a polymer. The translocation time τ that we examine is the unbiased (no charge on
the chain and no driving force) escape time of a polymer that is initially placed halfway through a pore perforated in a monolayer
wall. In particular, we look at the effect of increasing the pore radius when only a small number of fluid particles can be
located in the pore as the polymer undergoes translocation, and we compare our results to the theoretical predictions of Chuang
et al. (Phys. Rev. E 65, 011802 (2001)). We observe that the scaling of the translocation time varies from τ ∼ N
11/5 to τ ∼ N
9/5 as the pore size increases (N is the number of monomers that goes up to 31 monomers). However, the scaling of the polymer relaxation time remains consistent
with the 9/5 power law for all pore radii. 相似文献
16.
17.
We investigate theoretically the magnetization dynamics of a conducting magnetic nanoparticle weakly coupled to source and drain electrodes, under the assumption that all relaxation comes from exchange of electrons with the electrodes. In the regime of sequential tunneling, the magnetization dynamics is characterized by a relaxation time t(1), which strongly depends on temperature, bias voltage, and gate voltage. While a direct measure of a nanoparticle magnetization might be difficult, we find that t(1) can be determined through a time resolved transport measurement. For a suitable choice of gate voltage and bias voltage, the magnetization performs a bias-driven Brownian motion regardless of the presence of anisotropy. 相似文献
18.
We investigate the dynamics of DNA translocation through a nanopore using 2D Langevin dynamics simulations, focusing on the dependence of the translocation dynamics on the details of DNA sequences. The DNA molecules studied in this work are built from two types of bases A and C, which have been shown previously to have different interactions with the pore. We study DNA with repeating blocks A(n)C(n) for various values of n and find that the translocation time depends strongly on the block length 2n as well as on the orientation of which base enters the pore first. Thus, we demonstrate that the measurement of translocation dynamics of DNA through a nanopore can yield detailed information about its structure. We have also found that the periodicity of the block sequences is contained in the periodicity of the residence time of the individual nucleotides inside the pore. 相似文献
19.
Using a special double-layer membrane to avoid interaction among flow fields generated by different pores, we have, for the first time, observed the predicted discontinuous first-order transition in ultrafiltration of flexible linear polymer chains. Namely, the chain could pass through a pore much smaller than its unperturbed radius only when the flow rate is higher than a certain value. When only one chain and one pore are considered in theory, such a threshold is surprisingly independent of both the chain length and the pore size. Our results reveal that for a membrane with many pores and at a microscopic flow rate () lower than the threshold, the inevitable blocking of some pores by longer nonstretched coiled chains increases in those unblocked pores because the macroscopic flow rate () is a constant. Long chains have two populations, coiled and stretched, in a real ultrafiltration experiment when is lower than the threshold. 相似文献
20.
Single file translocation of a homopolymer through an active channel under the presence of a driving force is studied using Langevin dynamics simulation. It is shown that a channel with sticky walls and oscillating width could lead to significantly more efficient translocation as compared to a static channel that has a width equal to the mean width of the oscillating pore. The gain in translocation exhibits a strong dependence on the stickiness of the pore, which could allow the polymer translocation process to be highly selective. 相似文献