Driven translocation dynamics of polynucleotides through a nanopore: off-lattice Monte-Carlo simulations |
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| Institution: | 1. The Technical University of Cluj-Napoca, The Directorate of Research, Development and Innovation Management (DMCDI), Constantin Daicoviciu Street, no. 15, Cluj-Napoca 400020, Cluj county, Romania;2. Motilal Nehru National Institute of Technology, Department of Physics, Allahabad, UP 211004, India;3. Brno University of Technology, Faculty of Electrical Engineering and Communication, Physics Department, Technická 8, 616 00 Brno, Czech Republic;4. Central European Institute of Technology, Purkyňova 123, 61600 Brno, Czech Republic;5. Young Researchers and Elite Club, West Tehran Branch, Islamic Azad University, Tehran, Iran;1. Biology Department, Faculty of Science and Art, Uludag University, Bursa, Turkey;2. Textile Engineering Department, Engineering Faculty, Uludag University, Bursa, Turkey;1. Istituto per le Applicazioni del Calcolo – CNR, Via dei Taurini, 19-00185 Rome, Italy;2. Dipartimento di Matematica e Fisica “E. De Giorgi”, University of Salento & National Nanotechnology Laboratory of Istituto Nanoscienze – CNR, Via Arnesano, 73100 Lecce, Italy;1. Center for Nanofibers and Nanotechnology, Nanoscience and Nanotechnology Initiative, Faculty of Engineering, National University of Singapore, Singapore;2. Amity Institute of Nanotechnology, Amity University, Noida, UP, India;1. Department of Naval Architecture and Marine Engineering, Bandirma Onyedi Eylul University,TR-10200 Balikesir, Turkey;2. Department of Electrical and Electronics Engineering, Istanbul University, 34340 Istanbul, Turkey |
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| Abstract: | The driven translocation dynamics of a polynucleotide chain through a nanopore is studied using off-lattice Monte-Carlo simulations, which plays an important role in the nanopore sequencing of polynucleotides. We report a detailed study on the dependence of translocation dynamics on the chain length and the local geometry near the nanopore. In particular, we find that the length dependence of the infection time of the chain could exhibit very different behaviors for different geometries. |
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