共查询到18条相似文献,搜索用时 234 毫秒
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作者合成了6-氟-3-(取代)苯基-4-(1H)-喹啉酮的5-氯衍生物与7-氯衍生物,二者极性差异小,难于分离,以混合物形式存在.所合成的化合物均未见文献报道,本文通过1H NMR上的化学位移、积分面积以及偶合常数确证了混合物中两组份的结构. 相似文献
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本文报道了16种2(1H)喹啉酮及其开环衍生物的碳谱研究,归属了取代喹啉酮母核骨架及侧链上每个碳原子的化学位移,并就卤素取代对母核骨架碳的化学位移影响规律进行了探讨.文中所有化合物的核磁数据迄今未见文献报道. 相似文献
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通过对5种2-取代苯基-1,2-二氢-3-哒嗪酮-6-葡萄糖苷的1H NMR和IR谱的分析,确证其糖苷键为β-构型,用1H-1H COSY技术对它们的1H谱峰进行了归属. 相似文献
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张福兰 《原子与分子物理学报》2016,33(3):415-421
采用密度泛函理论中的广义梯度近似(DFT/GGA)方法,在PW91/DNP水平上研究了21种2,3-二取代喹唑啉-4(3H)-酮化合物的结构、化学活性和前线轨道.结果表明:此类化合物的能隙E_g大部分都在3.50~3.60 e V之间,其中在喹唑啉环3位上取代甲氧基苄基,或是在8位上取代甲基,化合物的能隙降低,而且甲氧基在苄基的间位比对位降低得更厉害.通过比较还发现,2,3-二取代喹唑啉-4(3H)-酮化合物对水稻纹枯菌(Rhizoctonia solani bacteria)的杀菌活性与哌啶并噻吩并嘧啶酮衍生物对水稻纹枯菌的杀菌活性相当,而哌啶并噻吩并嘧啶酮衍生物比2,3-二取代喹唑啉-4(3H)-酮化合物对苹果轮纹病(Botryospuaeria gregaria bacteria)杀菌活性好. 相似文献
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4-(2-羟基-4-硝基苯偶氮)-1-苯基-3-甲基吡唑啉酮光度法测定烟草中镁 总被引:2,自引:0,他引:2
研究了 4 - (2 -羟基 - 4-硝基苯偶氮 ) - 1-苯基 - 3-甲基吡唑啉酮 (HNAPMP)与镁的显色反应 ,在 p H=10的硼砂 -氢氧化钠缓冲介质中 ,HNAPMP与镁反应生成 2∶ 1稳定络合物 ,λmax=5 2 2 nm,ε=3.5 8× 10 4L·mol-1· cm-1。镁含量在 0— 2 0 μg/2 5 m L范围内符合比耳定律 ,方法用于烟草样品中镁含量的测定 ,结果令人满意 相似文献
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采用向关键中间体7a-(2, 4-二氯苯基)-3-苯基-2, 3, 4, 6, 7, 7a-六氢-5H-吡咯并[2, 1-b]- 唑-5-酮(化合物1)引入一个已知手性中心的策略,通过2D 1H-1H COSY谱和1D NOESY谱对化合物1和手性化合物α-[(2-甲基-3-氯苄基)氨甲酰基甲基]-γ-(2, 4-二氯苯-基)-N-{[3-(哌啶-1-基)丙基]氨甲酰基甲基}-γ-内酰胺(化合物2)的立体化学进行了研究.该方法对这类手性γ-内酰胺类化合物绝对构型的确定具有准确、方便、简单、快捷的特点. 相似文献
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Chih-Hua Tseng Chi-Yi Li Chien-Chih Chiu Huei-Ting Hu Chein-Hwa Han Yeh-Long Chen Cherng-Chyi Tzeng 《Molecular diversity》2012,16(4):697-709
A number of 2,4,5-triaryl-1H-imidazole derivatives were synthesized and evaluated for their antiproliferative activities against the growth of five cell lines including three non-small cell lung cancers (H460, H1299, and A549), one breast cancer (MCF-7), and one normal diploid embryonic lung cell line (MRC-5). Preliminary results indicated that both 2-(5-bromofuran-2-yl)-4,5-bis{4-[3-(dimethylamino) propoxy] phenyl}-1H-imidazole (10f) and 4,5-bis{4-[3-(dimethylamino)propoxy]phenyl}-2-(5-nitrofuran-2-yl)-1H -imidazole (10g) were selectively active against the growth of H1229 with an IC50 of less than 0.1???M, thus were more active than topotecan (IC50 >?10.0??? M). However, both 10f and 10g exhibited only marginal cytotoxicity against H460, A549, MCF-7, and MRC-5 requiring an IC 50 of at least 4.16???M. Our results also indicated that 10f induced H1299 cell cycle arrest at G0/G1 through the inactivation of p38 MAPK, JNK, ERK, as well as the expression of SIRT1 and survivin. These results suggested that 10f might have therapeutic potential against H1299 (non-small cell lung cancer cell). 相似文献
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通过Cu(I)催化有机叠氮化物和端基炔之间的1,3-偶极Huisgen环加成反应,又称“点击化学”, 可快速、高效合成专一的1,4-二取代-1,2,3-三唑产物. 为得到含有末端炔的喹啉酮衍生物,以7,8-二氢-2,5(1H,6H)-二酮(1)为原料,通过烷基化反应将端基炔引入到化合物1中,合成了1-(2-炔丙基)-7,8-二氢喹啉-2,5(1H, 6H) 二酮(3),并利用重结晶和硅胶柱分离两种化学手段,得到了该化合物的两种构型异构体. 采用DEPT、1H NMR、13C NMR、1H-1H COSY、NOESY、HMQC多种NMR实验测试分析方法,对该化合物的构型异构体进行了验证和区分,并分别对其1H NMR和13C NMR谱的信号进行了归属. 相似文献
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本文对二种新合成的2,3-二羟基萘二钼和四钼多酸有机衍生物[n-Bu)4N]2[Mo2O5(OC10H6O)2](Ⅰ)和[n-Bu)4N]2[Mo4O10(OC10H6O)2(OCH3)2](Ⅱ)进行了红外光谱与核磁共振波谱研究,发现[Mo2O5]^2 中钼氧多桥键的红外振动频率较[Mo4O10(OCH3)2]^2 中钼氧多桥键的红外振动频率红移,而在配合物Ⅱ中2,3-二羟基中芳环的^1H化学位移较配合物Ⅰ中向低场移动。同时还发现含二钼配位中心[Mo2O5]^2 的[Mo2O5(OC10H6O)2]^2-与含四钼配位中心[Mo4O10(OCH3)2]^2 的[Mo4O10(OC10H6O)2(OCH3)2]^2-生成条件的差异仅仅只在反应体系的pH值的微小变化,说明钼多酸有机衍生物阴离子是对体系酸碱度极为敏感的物质。 相似文献
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研究了一类喹喔啉衍生物 ,1 烷基 3 甲基 2 (1H) 喹喔啉 2 酮 (1 alkyl 3 methyl 2 (1H) quinoxalin 2 one,简称AMQ ,其中alkyl =H ,CH3,C2 H5,n C3H7,n C5H1 1 ,n C1 6 H33)的紫外吸收光谱。这类化合物可应用于药物 ,如用作α 氨基羟甲基异恶唑丙酸 (AMPA)受体拮抗剂、杀菌剂等 ;还可用作植物生长调节剂、荧光探针等领域。结果表明 :化合物中氮原子上烷基链的增长对该类喹喔啉衍生物的紫外吸收光谱基本没有影响 ,谱图中峰形大体相同。紫外吸收谱图中 ,在 32 7和 340nm左右有两个吸收强度相当的一对肩峰 ,2 80nm处有一个吸收强度稍弱的峰 ;340nm左右的吸收峰主要是n→Π 跃迁所致 ,其中也含有Π→Π 跃迁的成分 ;32 7和2 80nm左右强吸收峰是Π→Π 跃迁所致。 相似文献
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Carbon-13 chemical shifts of 3-Carboxy, 3-methoxy or ethoxy carbonyl or 3-carboxy analide -6-chloro-4-hydroxy-2-oxo-pyran (1), 7-chloro or 7-morpholino-3-substituted-3,4-dihydro-4, 5-dioxo-2-thio or oxo-2H, 5H-Pyrano [3, 4-e]-1, 3-oxazine (2 or 3) and 2-substituted phenyl carbamoyl-3-morpholino-N, N-glutaconoyl-dimorpholine (4) were assigned using first order and long range CH coupling constant. 相似文献
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S Safaei I Mohammadpoor-Baltork AR Khosropour M Moghadam S Tangestaninejad V Mirkhani 《Molecular diversity》2012,16(3):591-600
A variety of pyrazolo[3,4-d]pyrimidine-6(7H)-thione derivatives were easily synthesized with a novel, simple, efficient, and regioselective method via three-component condensation reaction of 5-methyl-1H-pyrazol-3-amine, arylisothiocyanates, and aldehydes in the presence of catalytic amount of p-toluenesulfonic acid (p-TSA) in 1-butyl-3-methylimidazolium bromide ionic liquid with excellent yields and short reaction times. 相似文献
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Elucidation of the structure of hitherto unknown novel pyranobisquinoline derivatives, (7H)-6,8-Dichloro-7-methyl -pyrano(3,2-c;5,6-c′)bisquinoline 5 and (7H)-6,8-Dichloro-7-methyl-pyrano(3,2-c:5,6-b′)bisquinoline 4 obtained as unexpected products1 in the Michael type reaction of vinylacetate on 4-hydroxyquinoline-2(lH)-one 1 by NMR methods is reported. 相似文献
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Norma N. Buceta Diego Ruiz Gustavo P. Romanelli Juan C. Autino Helmut Duddeck Reinaldo Pis Diez Jorge L. Jios 《Journal of Physical Organic Chemistry》2014,27(2):106-113
The experimental 1H and 13C NMR spectra of 13 phenyl cinnamates and four 4‐methylcoumarins were investigated and their chemical shifts assigned on the basis of the two‐dimensional spectra. For the unsubstituted cinnamic acid phenyl ester, optimized molecular structures were calculated at a B3LYP/6‐311++G(d,p) level of theory. 1H and 13C NMR chemical shifts were also calculated with the GIAO method at the B3LYP/6‐311 + G(2d,p) level of theory. The comparison between experimental and calculated NMR chemical shift suggests that the experimental spectra are formed from the superposition spectra of the two lowest energy conformers of the compound in solution. The most stable s‐cis configuration found in our studies is also the conformation adopted for a related phenyl cinnamate in solid state. The experimental results were analyzed in terms of the substituent effects. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献