| 1H NMR确证6-氟-5(或7)-氯-3-苯基-4-(1H)-喹啉酮衍生物的结构 |
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| 引用本文： | 王晓莉,徐鸣夏.1H NMR确证6-氟-5(或7)-氯-3-苯基-4-(1H)-喹啉酮衍生物的结构[J].波谱学杂志,1998,15(6):543-546. |
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| 作者姓名： | 王晓莉 徐鸣夏 |
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| 作者单位： | 华西医科大学药学院, 成都 610041 |
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| 摘 要： | 作者合成了6-氟-3-(取代)苯基-4-(1H)-喹啉酮的5-氯衍生物与7-氯衍生物,二者极性差异小,难于分离,以混合物形式存在.所合成的化合物均未见文献报道,本文通过1H NMR上的化学位移、积分面积以及偶合常数确证了混合物中两组份的结构.
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| 关 键 词： | 3-苯基-4-(1H)-喹啉酮 1H NMR 心血管活性 |
| 收稿时间： | 1998-07-20 |
THE STUDY ON 1H NMR OF 5(7)-CHLORO-6-FLURO-3-PHENYL-4-(1H)-QUINOLINONE DERIVATIVES |
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| Wang Xiaoli,Xu Mingxia,Su Fu.THE STUDY ON 1H NMR OF 5(7)-CHLORO-6-FLURO-3-PHENYL-4-(1H)-QUINOLINONE DERIVATIVES[J].Chinese Journal of Magnetic Resonance,1998,15(6):543-546. |
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| Authors: | Wang Xiaoli Xu Mingxia Su Fu |
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| Institution: | School of Pharmacy, West China University of Medical Sciences, Chendu 610041 |
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| Abstract: | Isoflavonoids are recognized to possess broad biological activities, such as cardiovascular, estrogenicity and so on.3-Pheny l-4(1H)-quinolinone derivatives are isosteres of isoflavonoids and they have similar spatial structures.So perhaps they can exhibit similar activities.5- Chloro-6-fluro-3-phenyl-4-(1H)-quinolinone derivatives and 7-chloro-6-fluro-3-phenyl-4- (1H)-quinolinone derivatives were desig ned and synthesized at the same time.It's difficult to separate them due to their similar polarity.Only two isomeres (4a, 4b)were separated. 1, 2, 3 were mix tures due to their similar polarity of the two corresponding isomeres.The structures were confirmed by 1H NMR and the contents of the mixtures were determined by HPLC. |
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| Keywords: | 3-phenyl-4-(1H)-quinolinone Derivatives 1H NMR Cardiovascular activity |
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