| ~1H NMR确证6-氟-5(或7)-氯-3-苯基-4-(1H)-喹啉酮衍生物的结构 |
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| 引用本文： | 王晓莉,徐鸣夏,苏甫.~1H NMR确证6-氟-5(或7)-氯-3-苯基-4-(1H)-喹啉酮衍生物的结构[J].波谱学杂志,1998(6). |
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| 作者姓名： | 王晓莉 徐鸣夏 苏甫 |
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| 作者单位： | 华西医科大学药学院 |
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| 摘 要： | 作者合成了６氟３（取代）苯基４（１Ｈ）喹啉酮的５氯衍生物与７氯衍生物，二者极性差异小，难于分离，以混合物形式存在．所合成的化合物均未见文献报道，本文通过１ＨＮＭＲ上的化学位移、积分面积以及偶合常数确证了混合物中两组份的结构．
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| 关 键 词： | 3-苯基-4-（1H）-喹啉酮，~1H NMR，心血管活性 |
THE STUDY ON 1H NMR OF 5(7) CHLORO 6 FLURO 3 PHENYL 4 (1H) QUINOLINONE DERIVATIVES |
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| Wang Xiaoli,Xu Mingxia and Su Fu.THE STUDY ON 1H NMR OF 5(7) CHLORO 6 FLURO 3 PHENYL 4 (1H) QUINOLINONE DERIVATIVES[J].Chinese Journal of Magnetic Resonance,1998(6). |
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| Authors: | Wang Xiaoli Xu Mingxia and Su Fu |
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| Institution: | Wang Xiaoli,Xu Mingxia * and Su Fu |
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| Abstract: | Isoflavonoids are recognized to possess broad biological activities, such as cardiovascular, estrogenicity and so on. 3 Phenyl 4(1H) quinolinone derivatives are isosteres of isoflavonoids and they have similar spatial structures. So perhaps they can exhibit similar activities. 5 Chloro 6 fluro 3 phenyl 4 (1H) quinolinone derivatives and 7 chloro 6 fluro 3 phenyl 4 (1H) quinolinone derivatives were designed and synthesized at the same time. It's difficult to separate them due to their similar polarity. Only two isomeres (4a,4b) were separated. 1,2,3 were mixtures due to their similar polarity of the two corresponding isomeres. The structures were confirmed by 1H NMR and the contents of the mixtures were determined by HPLC. |
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| Keywords: | phenyl 4 (1H) quinolinone Derivatives 1H NMR Cardiovascular activity |
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