左删失右截断数据的分位数的固定宽度序贯置信区间估计

基于左截断右删失数据下的乘积限估计构造了分位数固定宽度序贯置信区间及其估计，研究了序贯置信区间估计的渐近性质。作为副产品，获得了分位数估计近邻点的Bahadur表示定理。这个表示定理是推导分位数固定宽度序贯置信区间估计渐近性质的重要基础。同时，在文中，进行了一些计算机模拟试验，证明了左截断右删失数据下分位数估计的序贯方法是效的和精确的。     

左截断右删失模型下乘积限估计的强大数律(Ⅱ)

对左截断右删失模型，在不要求分布函数连续的条件下，给出乘积限估计F_n是真分布的一致强相合估计的完整结果．作为推论，还给出右删失模型下的K－M估计和左截断模型下的乘积限估计的一致强相合性的完整结果．     

截断样本下的强率函数和密度函数核估计的渐进正态性

本文用[1]发展的计数过程去研究截断样本下强率函数核估计的渐进正态性．在弱于[7]和[10]的条件下，得到了更一般的结果．接着我们将这种方法运用到密度函数核估计，在较弱的条件下，得到了截断样本下密度函数核估计的渐进正态性．     

左截断右删失数据下分位密度估计的重对数律

在左截断右删失数据下，我们基于乘积限估计给出了分位密度估计， 获得了分位密度估计及其导数的重对数律。     

随机右截断情形下连续过程生存函数的估计及其性质

截断数据是生存分析的重要研究内容，而以往关于截断数据的讨论仅限于离散场合．本文将截断数据的问题推广到连续场合，对右截断下连续过程的生存函数的估计进行了讨论，并进一步证明了估计量的强相合性．     

生存分析中乘积限估计的大样本性质

生存分析中，人们关心的问题之一是利用不完全的寿命调查数据估计生物折寿命分布。在实际问题中，比较常见的不完全数据包括右删失数据，左截断数据和左截断右删失数据。利用这三种数据估计寿命分布时，常用的统计量是乘积限估计。于是，乘积限估计的大样本性质的研究一直受到关注。本文就这方面的研究近况做一比较系统的论述。     

左截断右删失数据分位差估计及其渐近性质

我们研究了左截断右删失数据分位差,基于左截断右删失数据乘积限构造了分位差的经验估计,同时克服经验估计的非光滑性,提出了分位数差的核光滑估计.利用经验过程理论推导出这两个估计的渐近偏差和渐近方差,并且在左截断右删失数据下研究了这两个分位差的大样本性质,获得分位差估计的相合性和渐近正态性.同时给出计算模拟以验证光滑分位差估计的表现,在均方损失的意义下模拟结果表明光滑估计比经验估计具有更好的性质.     

左截断数据下非线性模型的加权分位数回归

左截断数据是一类具有特殊结构的缺失数据,当且仅当研究变量大于一定的阈值时才能取得观察值.本文针对左截断数据下的非线性回归模型,提出了加权分位数估计方法,利用加权方式处理左截断缺失数据,取得了与完整数据相近的估计结果.并在一定假设条件下,证明了所提估计方法的一致性和渐近正态性等大样本性质,最后通过数值模拟展现所提估计方法的有限样本表现.     

关于寿命试验

本文讨论了关于寿命试验的一些问题,全文共分四个部分．第一部分分析了截断情况下寿命估计的困难;第二部分考虑对定时寿命试验方法进行修改,以获取分布尾部的信息;第三部分研究在随机截断下基于Ｋａｐｌａｎ－Ｍｅｉｅｒ估计的非参数寿命均值估计;第四部分讨论了第二类截断下定数ｒ的选择问题．     

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本文研究了线性模型响应变量被污染且被区间截断下的参数估计问题, 借助于区间数据的无偏转换, 得到了回归系数和污染系数的估计, 并在一定的条件下得到了这些估计的强相合性. 通过若干模拟例子说明, 尽管数据经过污染和区间截断的双重信息损失, 但用本文提出的方法得到的估计, 仍能取得良好的估计效果     

区间数据的均值估计

本文在运用无偏转换思想找到区间数据均值估计的基础上,对所找到的估计量的方差进行了研究.针对区间截断情况1和区间截断情况2,找到了估计量方差有限的条件.当截断随机变量的分布在某种程度上比被截断随机变量的分布尾部更厚时,方差有限的估计量可以取到.     

Multiple imputations and the missing censoring indicator model

Semiparametric random censorship (SRC) models (Dikta, 1998) provide an attractive framework for estimating survival functions when censoring indicators are fully or partially available. When there are missing censoring indicators (MCIs), the SRC approach employs a model-based estimate of the conditional expectation of the censoring indicator given the observed time, where the model parameters are estimated using only the complete cases. The multiple imputations approach, on the other hand, utilizes this model-based estimate to impute the missing censoring indicators and form several completed data sets. The Kaplan-Meier and SRC estimators based on the several completed data sets are averaged to arrive at the multiple imputations Kaplan-Meier (MIKM) and the multiple imputations SRC (MISRC) estimators. While the MIKM estimator is asymptotically as efficient as or less efficient than the standard SRC-based estimator that involves no imputations, here we investigate the performance of the MISRC estimator and prove that it attains the benchmark variance set by the SRC-based estimator. We also present numerical results comparing the performances of the estimators under several misspecified models for the above mentioned conditional expectation.     

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In collecting clinical data, data would be censored due to competing risks or patient withdrawal. The statistical inference for censoring data is always based on the assumption that the failure time and censoring time is independent. But in practice the failure time and censoring time are often dependent. Dependent censoring make the job to deal with censoring data more complicated. In this paper, we assume that the joint distribution of the failure time variable and censoring time variable is a function of their marginal distributions. This function is called a copula. Under prespecified copulas, the maximum likelihood estimators for cox proportional hazards models are worked out. Statistical analysis results are carried by simulations. When dependent censoring happens, the proposed method will do better than the traditional method used in independent situations. Simulation results show that the proposed method can get efficient estimations.     

Smoothing estimation of rate function for recurrent event data with informative censoring

This paper proposes kernel estimation of the occurrence rate function for recurrent event data with informative censoring. An informative censoring model is considered with assumptions made on the joint distribution of the recurrent event process and the censoring time without modeling the censoring distribution. Under the validity of the informative censoring model, we also show that an estimator based on the assumption of independent censoring becomes inappropriate and is generally asymptotically biased. To investigate the asymptotic properties of the proposed estimator, the explicit form of its asymptotic mean squared risk and the asymptotic normality are derived. Meanwhile, the empirical consistent smoothing estimator for the variance function of the estimator is suggested. The performance of the estimators are also studied through Monte Carlo simulations. An epidemiological example of intravenous drug user data is used to show the influence of informative censoring in the estimation of the occurrence rate functions for inpatient cares over time.     

混合截尾和定时截尾试验weibull分布抽样方案的比较

混合截尾试验是定时和定数截尾的一种有用的推广。本文研究了Ｗｅｉｂｕｌｌ分布和混合截尾试验的一次抽样方案,并对可靠决策损失函数给出了贝叶斯风险的显式表达式。比较陈和林的模型（１９９９）,我们得混合截尾试验的抽样方案于定时抽样方案。     

Nonparametric estimation of interval-censored failure time data in the presence of informative censoring

Nonparametric estimation of a survival function is one of the most commonly asked questions in the analysis of failure time data and for this, a number of procedures have been developed under various types of censoring structures (Kalbfleisch and Prentice, 2002). In particular, several algorithms are available for interval-censored failure time data with independent censoring mechanism (Sun, 2006; Turnbull, 1976). In this paper, we consider the interval-censored data where the censoring mechanism may be related to the failure time of interest, for which there does not seem to exist a nonparametric estimation procedure. It is well-known that with informative censoring, the estimation is possible only under some assumptions. To attack the problem, we take a copula model approach to model the relationship between the failure time of interest and censoring variables and present a simple nonparametric estimation procedure. The method allows one to conduct a sensitivity analysis among others.     

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??In survival analysis, most existing approaches for analysing right-censored failure time data assume that the censoring time is independent of the failure time. However, investigators often face problems involving dependent censoring, i.e., failure time and censoring time are possibly dependent and they may be censored one another, especially in clinical trials. Without accounting for such dependence, survival distributions cannot be estimated consistently. Numerous attempts to model this dependence have been made. Among them, copula models are of particular interest because of their simple structure. Proportional hazard model analysis for informative right-censored data has been discussed in this paper. An Archimedean copula is assumed for the joint distribution function of failure time and censoring time variables. Under the conditions of identifiability of the parameter of the Archimedean copula, the maximum likelihood estimators of the parameter of Archimedean copula, the parameters and the cumulative hazard function of PH model are worked out. Extensive simulation studies show that the feasibility of the proposed method and the consistency of the estimators.     

Optimum life testing plans in presence of hybrid censoring: A cost function approach

Hybrid censoring scheme is a combination of Type‐I and Type‐II censoring schemes. Determination of optimum hybrid censoring scheme is an important practical issue in designing life testing experiments to enhance the information on reliability of the product. In this work, we consider determination of optimum life testing plans under hybrid censoring scheme by minimizing the total cost associated with the experiment. It is shown that the proposed cost function is scale invariant for some selected distributions. Optimum solution cannot be obtained analytically. We propose a method for obtaining the optimum solution and consider Weibull distribution for illustration. We also studied the sensitivity of the optimal solution to the misspecification of parameter values and cost components through a well‐designed sensitivity analysis. Copyright © 2013 John Wiley & Sons, Ltd.     

删失数据中删失指标随机缺失下回归函数的非参数估计

本文在删失数据中删失指标随机缺失的情况下,运用非参数方法给出了回归函数的两种估计量,给出了估计量的一致收敛速度以及渐近分布,并进一步通过数值模拟验证了所提方法在有限样本下的性质.     

Life expectancy under random censorship

This paper deals with estimation of life expectancy used in survival analysis and competing risk study under the condition that the data are randomly censored by K independent censoring variables. The estimator constructed is based on a theorem due to Berman [2], and it involves an empirical distribution function which is related to the Kaplan-Meier estimate used in biometry. It is shown that the estimator, considered as a function of age, converges weakly to a Gaussian process. It is found that for the estimator to have finite limiting variance requires the assumption that the censoring variables be stochastically larger than the “survival” random variable under investigation.