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In collecting clinical data, data would be censored due to competing risks or patient withdrawal. The statistical inference for censoring data is always based on the assumption that the failure time and censoring time is independent. But in practice the failure time and censoring time are often dependent. Dependent censoring make the job to deal with censoring data more complicated. In this paper, we assume that the joint distribution of the failure time variable and censoring time variable is a function of their marginal distributions. This function is called a copula. Under prespecified copulas, the maximum likelihood estimators for cox proportional hazards models are worked out. Statistical analysis results are carried by simulations. When dependent censoring happens, the proposed method will do better than the traditional method used in independent situations. Simulation results show that the proposed method can get efficient estimations.     

Nonparametric estimation of interval-censored failure time data in the presence of informative censoring

Nonparametric estimation of a survival function is one of the most commonly asked questions in the analysis of failure time data and for this, a number of procedures have been developed under various types of censoring structures (Kalbfleisch and Prentice, 2002). In particular, several algorithms are available for interval-censored failure time data with independent censoring mechanism (Sun, 2006; Turnbull, 1976). In this paper, we consider the interval-censored data where the censoring mechanism may be related to the failure time of interest, for which there does not seem to exist a nonparametric estimation procedure. It is well-known that with informative censoring, the estimation is possible only under some assumptions. To attack the problem, we take a copula model approach to model the relationship between the failure time of interest and censoring variables and present a simple nonparametric estimation procedure. The method allows one to conduct a sensitivity analysis among others.     

Hazard Estimation With Bivariate Survival Data and Copula Density Estimation

Bivariate survival function can be expressed as the composition of marginal survival functions and a bivariate copula and, consequently, one may estimate bivariate hazard functions via marginal hazard estimation and copula density estimation. Leveraging on earlier developments on penalized likelihood density and hazard estimation, a nonparametric approach to bivariate hazard estimation is being explored in this article. The new ingredient here is the nonparametric estimation of copula density, a subject of interest by itself, and to accommodate survival data one needs to allow for censoring and truncation in the setting. A simple copularization process is implemented to convert density estimates into copula densities, and a cross-validation scheme is devised for density estimation under censoring and truncation. Empirical performances of the techniques are investigated through simulation studies, and potential applications are illustrated using real-data examples and open-source software.     

Estimation of nonstrict Archimedean copulas and its application to quantum networks

Bivariate nonstrict Archimedean copulas form a subclass of Archimedean copulas and are able to model the dependence structure of random variables that do not take on low quantiles simultaneously; i.e. their domain includes a set, the so‐called zero set, with positive Lebesgue measure but zero probability mass. Standard methods to fit a parametric Archimedean copula, e.g. classical maximum likelihood estimation, are either getting computationally more involved or even fail when dealing with this subclass. We propose an alternative method for estimating the parameter of a nonstrict Archimedean copula that is based on the zero set and the functional form of its boundary curve. This estimator is fast to compute and can be applied to absolutely continuous copulas but also allows singular components. In a simulation study, we compare its performance to that of the standard estimators. Finally, the estimator is applied when modeling the dependence structure of quantities describing the quality of transmission in a quantum network, and it is shown how this model can be used effectively to detect potential intruders in this network. Copyright © 2014 John Wiley & Sons, Ltd.     

Estimation and confidence bands of a conditional survival function with censoring indicators missing at random

The nonparametric estimator of the conditional survival function proposed by Beran is a useful tool to evaluate the effects of covariates in the presence of random right censoring. However, censoring indicators of right censored data may be missing for different reasons in many applications. We propose some estimators of the conditional cumulative hazard and survival functions which allow to handle this situation. We also construct the likelihood ratio confidence bands for them and obtain their asymptotic properties. Simulation studies are used to evaluate the performances of the estimators and their confidence bands.     

On the nonidentifiability property of Archimedean copula models under dependent censoring

In this paper, we prove a peculiar property shared by the Archimedean copula models, that is, different Archimedean copula models with distinct dependent levels can have the same crude survival functions for dependent censored data. This property directly shows the nonidentifiability property of the Archimedean copula models. The proposed procedure is then demonstrated by two examples.     

Analyzing right-censored length-biased data with additive hazards model

Length-biased data are often encountered in observational studies, when the survival times are left-truncated and right-censored and the truncation times follow a uniform distribution. In this article, we propose to analyze such data with the additive hazards model, which specifies that the hazard function is the sum of an arbitrary baseline hazard function and a regression function of covariates. We develop estimating equation approaches to estimate the regression parameters. The resultant estimators are shown to be consistent and asymptotically normal. Some simulation studies and a real data example are used to evaluate the finite sample properties of the proposed estimators.     

基于截断tau的copula模型选择及应用

本文引进了截断tau,计论了它与生存阿基米德Copula之间的关系,并在此基础上提出一种新的选择Copula模型的方法,实例分析表明,这种构建Copula模型的方法较好反映了数据内在的信息,客观描述金融变量的相关性,便于尾部相关性分析,为金融市场相关性分析提供了一种新途径.     

Semiparametric methods for left-truncated and right-censored survival data with covariate measurement error

Many methods have been developed for analyzing survival data which are commonly right-censored. These methods, however, are challenged by complex features pertinent to the data collection as well as the nature of data themselves. Typically, biased samples caused by left-truncation (or length-biased sampling) and measurement error often accompany survival analysis. While such data frequently arise in practice, little work has been available to simultaneously address these features. In this paper, we explore valid inference methods for handling left-truncated and right-censored survival data with measurement error under the widely used Cox model. We first exploit a flexible estimator for the survival model parameters which does not require specification of the baseline hazard function. To improve the efficiency, we further develop an augmented nonparametric maximum likelihood estimator. We establish asymptotic results and examine the efficiency and robustness issues for the proposed estimators. The proposed methods enjoy appealing features that the distributions of the covariates and of the truncation times are left unspecified. Numerical studies are reported to assess the finite sample performance of the proposed methods.

     

Regression analysis of right-censored failure time data with missing censoring indicators

This paper discusses regression analysis of right-censored failure time data when censoring indicators are missing for some subjects. Several methods have been developed for the analysis under different situations and especially, Goetghebeur and Ryan considered the situation where both the failure time and the censoring time follow the proportional hazards models marginally and developed an estimating equation approach. One limitation of their approach is that the two baseline hazard functions were assumed to be proportional to each other. We consider the same problem and present an efficient estimation procedure for regression parameters that does not require the proportionality assumption. An EM algorithm is developed and the method is evaluated by a simulation study, which indicates that the proposed methodology performs well for practical situations. An illustrative example is provided.