纵向数据广义部分线性模型的二次推断推断函数估计（英文）

针对纵向数据广义部分线性模型,通常的做法是用样条或核方法逼近非参部分,之后利用广义估计方程方法(GEE)估计参数部分.本文使用B样条逼近非参函数,并基于二次推断函数的方法对参数和非参数进行估计,并给出了估计量的大样本性质.模拟表明本文的方法改进了GEE的效率.     

双因素误差成分的空间面板模型的参数估计

本文构造了比较一般化的双因素误差成分结构的空间面板数据模型,其中误差成分的设定为个体效应也存在空间相关性.基于广义矩估计方法,通过构造最优的工具变量,寻找合适的矩条件组和权重矩阵,讨论了模型的参数估计问题,并证明了估计量的相合性.通过随机模拟分析估计量的有限样本性质,结果表明加权矩估计量的渐近效果优于未加权矩估计量,并且模型参数的可行的广义二阶段最小二乘估计量的估计效果很好.     

纵向数据下半参数回归模型的统计分析

对于纵向数据下半参数回归模型,基于广义估计方程和一般权函数方法构造了模型中参数分量和非参数分量的估计.在适当的条件下证明了参数估计量具有渐近正态性,并得到了非参数回归函数估计量的最优收敛速度.通过模拟研究说明了所提出的估计量在有限样本下的精确性.     

基于copula函数的纵向数据复合分位数回归及变量选择

复合分位数回归(composite quantile regression)具有稳健性好和估计效率高的优势,所以其经常被用来替代均值回归.众所周知,纵向数据具有组内相关的特点,如果估计过程中能正确地利用组内相关性,则可以显著地提高估计效率.因此,探讨纵向数据复合分位数回归中如何使用相关性是一个有意义的问题.本文首先利用copula函数方法构建纵向数据复合分位数回归的组内协方差矩阵,进而基于构建的协方差矩阵,提出一个无偏且有效的基于copula函数的复合分位数回归估计方程;进一步,为了进行变量选择,利用基于copula函数的估计方程,提出一个光滑门限(smooth-threshold)的复合分位数回归估计方程方法.本文提出的方法具有很高的灵活性,而且提高了估计的效率.理论结果以及数值模拟和实际数据分析都验证了本文的方法.     

纵向数据广义部分线性模型的惩罚GMM估计

对纵向数据的部分线性模型,通常的做法是用样条方法或者核方法逼近非参数部分,然后再用广义估计方程的估计方法去估计参数部分.本文使用P-样条拟合非参数函数,对不同的矩条件用不同的广义矩方法对模型的参数和非参数进行估计,并且给出了估计量的大样本性质;并用计算机模拟和实例证明了当模型中存在不同的矩条件时,采用不同的惩罚广义矩方法可以显著地提高估计精度.     

纵向数据半参数回归模型的估计方法

本文考虑纵向数据半参数回归模型,通过考虑纵向数据的协方差结构,基于Profile最小二乘法和局部线性拟合的方法建立了模型中参数分量、回归函数和误差方差的估计量,来提高估计的有效性,在适当条件下给出了这些估计量的相合性.并通过模拟研究将该方法与最小二乘局部线性拟合估计方法进行了比较,表明了Profile最小二乘局部线性拟合方法在有限样本情况下具有良好的性质.     

纵向数据均值和协方差矩阵的有效稳健估计（英文）

本文提出一种针对纵向数据回归模型下的均值和协方差矩阵同时进行的有效稳健估计.基于对协方差矩阵的Cholesky分解和对模型的改写,我们提出一个加权最小二乘估计,其中权重是通过广义经验似然方法估计出来的.所提估计的有效性得益于经验似然方法的优势,稳健性则是通过限制残差平方和的上界来达到.模拟研究表明,和已有的针对纵向数据的稳健估计相比,所提估计具有更高的效率和可比的稳健性.最后,我们把所提估计方法用来分析一组实际数据.     

纵向数据非参数混合效应模型的一个局部不变估计

非参数核回归方法近年来已被用于纵向数据的分析(Lin和Carroll,2000)．一个颇具争议性的问题是在非参数核回归中是否需要考虑纵向数据间的相关性．Lin和Carroll (2000)证明了基于独立性(即忽略相关性)的核估计在一类核GEE估计量中是(渐近)最有效的．基于混合效应模型方法作者提出了一个不同的核估计类,它自然而有效地结合了纵向数据的相关结构．估计量达到了与Lin和Carroll的估计量相同的渐近有效性,且在有限样本情形下表现更好．由此方法可以很容易地获得对于总体和个体的非参数曲线估计．所提出的估计量具有较好的统计性质,且实施方便,从而对实际工作者具有较大的吸引力．     

纵向数据下变系数混合效应模型的一种有效的压缩估计

本文考虑了纵向数据下变系数混合效应模型的一种有效的压缩估计。结合考虑纵向数据的组内相关性,本文提出的统一正则估计方法可以同时选择和估计系数函数的参数效应分量和非参数效应的函数分量。本文还建立了估计量的渐近理论性质,且在Monte Carlo模拟和实际数据分析进行了充分的验证。     

零漂移广义双曲线扩散过程构建和最优鞅估计函数

由于广义双曲线分布在资产收益率分布拟合中的优异表现,以规模测度和速度测度为工具,构建出边际分布服从广义双曲线分布的扩散过程.利用1.5阶强泰勒近似法离散化随机微分方程,以二次最优鞅估计函数法得到模型参数估计量,结果显示:鞅估计函数法能够快速、准确地对正态逆高斯扩散过程作出参数估计,并且能获得高精度渐近协方差矩阵.     

Empirical likelihood analysis of longitudinal data involving within-subject correlation

In this paper we use profile empirical likelihood to construct confidence regions for regression coefficients in partially linear model with longitudinal data. The main contribution is that the within-subject correlation is considered to improve estimation efficiency. We suppose a semi-parametric structure for the covariances of observation errors in each subject and employ both the first order and the second order moment conditions of the observation errors to construct the estimating equations. Although there are nonparametric estimators, the empirical log-likelihood ratio statistic still tends to a standard ?? _p ² variable in distribution after the nuisance parameters are profiled away. A data simulation is also conducted.     

Empirical likelihood semiparametric nonlinear regression analysis for longitudinal data with responses missing at random

This paper develops the empirical likelihood (EL) inference on parameters and baseline function in a semiparametric nonlinear regression model for longitudinal data in the presence of missing response variables. We propose two EL-based ratio statistics for regression coefficients by introducing the working covariance matrix and a residual-adjusted EL ratio statistic for baseline function. We establish asymptotic properties of the EL estimators for regression coefficients and baseline function. Simulation studies are used to investigate the finite sample performance of our proposed EL methodologies. An AIDS clinical trial data set is used to illustrate our proposed methodologies.     

Quantile estimations via modified Cholesky decomposition for longitudinal single-index models

Quantile regression is a powerful complement to the usual mean regression and becomes increasingly popular due to its desirable properties. In longitudinal studies, it is necessary to consider the intra-subject correlation among repeated measures over time to improve the estimation efficiency. In this paper, we focus on longitudinal single-index models. Firstly, we apply the modified Cholesky decomposition to parameterize the intra-subject covariance matrix and develop a regression approach to estimate the parameters of the covariance matrix. Secondly, we propose efficient quantile estimating equations for the index coefficients and the link function based on the estimated covariance matrix. Since the proposed estimating equations include a discrete indicator function, we propose smoothed estimating equations for fast and accurate computation of the index coefficients, as well as their asymptotic covariances. Thirdly, we establish the asymptotic properties of the proposed estimators. Finally, simulation studies and a real data analysis have illustrated the efficiency of the proposed approach.

     

Moderate deviations of generalized method of moments and empirical likelihood estimators

This paper studies moderate deviation behaviors of the generalized method of moments and generalized empirical likelihood estimators for generalized estimating equations, where the number of equations can be larger than the number of unknown parameters. We consider two cases for the data generating probability measure: the model assumption and local contaminations or deviations from the model assumption. For both cases, we characterize the first-order terms of the moderate deviation error probabilities of these estimators. Our moderate deviation analysis complements the existing literature of the local asymptotic analysis and misspecification analysis for estimating equations, and is useful to evaluate power and robust properties of statistical tests for estimating equations which typically involve some estimators for nuisance parameters.     

Efficient parameter estimation via modified Cholesky decomposition for quantile regression with longitudinal data

It is well known that specifying a covariance matrix is difficult in the quantile regression with longitudinal data. This paper develops a two step estimation procedure to improve estimation efficiency based on the modified Cholesky decomposition. Specifically, in the first step, we obtain the initial estimators of regression coefficients by ignoring the possible correlations between repeated measures. Then, we apply the modified Cholesky decomposition to construct the covariance models and obtain the estimator of within-subject covariance matrix. In the second step, we construct unbiased estimating functions to obtain more efficient estimators of regression coefficients. However, the proposed estimating functions are discrete and non-convex. We utilize the induced smoothing method to achieve the fast and accurate estimates of parameters and their asymptotic covariance. Under some regularity conditions, we establish the asymptotically normal distributions for the resulting estimators. Simulation studies and the longitudinal progesterone data analysis show that the proposed approach yields highly efficient estimators.     

Weighted estimating equation: modified GEE in longitudinal data analysis

The method of generalized estimating equations （GEE） introduced by K. Y. Liang and S. L. Zeger has been widely used to analyze longitudinal data. Recently, this method has been criticized for a failure to protect against misspecification of working correlation models, which in some cases leads to loss of efficiency or infeasibility of solutions. In this paper, we present a new method named as ＇weighted estimating equations （WEE）＇ for estimating the correlation parameters. The new estimates of correlation parameters are obtained as the solutions of these weighted estimating equations. For some commonly assumed correlation structures, we show that there exists a unique feasible solution to these weighted estimating equations regardless the correlation structure is correctly specified or not. The new feasible estimates of correlation parameters are consistent when the working correlation structure is correctly specified. Simulation results suggest that the new method works well in finite samples.     

Additive hazards regression with random effects for clustered failure times

Additive hazards model with random effects is proposed for modelling the correlated failure time data when focus is on comparing the failure times within clusters and on estimating the correlation between failure times from the same cluster, as well as the marginal regression parameters. Our model features that, when marginalized over the random effect variable, it still enjoys the structure of the additive hazards model. We develop the estimating equations for inferring the regression parameters. The proposed estimators are shown to be consistent and asymptotically normal under appropriate regularity conditions. Furthermore, the estimator of the baseline hazards function is proposed and its asymptotic properties are also established. We propose a class of diagnostic methods to assess the overall fitting adequacy of the additive hazards model with random effects. We conduct simulation studies to evaluate the finite sample behaviors of the proposed estimators in various scenarios. Analysis of the Diabetic Retinopathy Study is provided as an illustration for the proposed method.     

EMPIRICAL LIKELIHOOD APPROACH FOR LONGITUDINAL DATA WITH MISSING VALUES AND TIME-DEPENDENT COVARIATES

Missing data and time-dependent covariates often arise simultaneously in longitudinal studies, and directly applying classical approaches may result in a loss of efficiency and biased estimates. To deal with this problem, we propose weighted corrected estimating equations under the missing at random mechanism, followed by developing a shrinkage empirical likelihood estimation approach for the parameters of interest when time-dependent covariates are present. Such procedure improves efficiency over generalized estimation equations approach with working independent assumption, via combining the independent estimating equations and the extracted additional information from the estimating equations that are excluded by the independence assumption. The contribution from the remaining estimating equations is weighted according to the likelihood of each equation being a consistent estimating equation and the information it carries. We show that the estimators are asymptotically normally distributed and the empirical likelihood ratio statistic and its profile counterpart follow central chi-square distributions asymptotically when evaluated at the true parameter. The practical performance of our approach is demonstrated through numerical simulations and data analysis.     

Semiparametric analysis of longitudinal data with informative observation times

In many longitudinal studies,observation times as well as censoring times may be correlated with longitudinal responses.This paper considers a multiplicative random effects model for the longitudinal response where these correlations may exist and a joint modeling approach is proposed via a shared latent variable.For inference about regression parameters,estimating equation approaches are developed and asymptotic properties of the proposed estimators are established.The finite sample behavior of the methods is examined through simulation studies and an application to a data set from a bladder cancer study is provided for illustration.     

Orthoregressive estimates for the parameters of systems of linear difference equations

The problem of estimating the parameters of linear difference systems of equations from the observations of the segments of solutions with additive stochastic perturbations is considered. The methods of multivariate orthogonal regression are applied to obtain the estimators. The results of comparative study of the methods are exposed from the standpoint of information on linear constraints in observations. The properties of the estimators in the limit cases of a gross sample are studied. For small perturbations, a scheme for comparison of estimators by linear approximations is proposed.