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对全国各地用原子吸收光谱仪测定10批次大活络丸中12种无机元素及建立的指纹图谱,尝试用成分数据分析法、向量相似法和模糊聚类法建立全国无机元素的指纹图谱和中药质量控制标准方法,获得较满意的结果。研究表明,建立无机元素指纹图谱控制中成药中无机元素的质量,具有很好的实用性和可操作性,用于全国各地不同厂家生产的大活络丸无机元素的质量控制是切实可行的。 相似文献
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中药的现代化对中药材及其制剂中重金属的质量控制提出更高要求.本文以Cu2+测定为例,通过测定颜色变化建立了中成药中重金属离子可视化数值分析方法.研究发现,在生理条件下,Cu2+与氨基黑10B可发生氧化还原反应,溶液颜色由蓝色逐渐变为桃红色.通过计算机常规软件Image-Pro Plus6.0获取溶液颜色变化过程中的红绿蓝三原色(R,G,B)数值,发现单位像素内R值的增加与溶液中8.33×10-8~1.33×10-6mol/L范围内的Cu2+具有良好的线性关系.该法可应用于典型中成药补中益气丸、安神胶囊、健胃消食片等药品中Cu2+的检测. 相似文献
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中成药中有机氯类农药残留量的毛细管气相色谱测定方法的研究 总被引:6,自引:0,他引:6
1引言中成药由多味动物、植物或矿物药组成,其质量的好坏,直接影响到患者的安全和疗效,而质量问题通常包括二个方面:(1)有效,(2)安全。随着生活水平的提高,绿色革命的积极推行,人们进一步认识到残存农药对人体健康的危害性。故建立其农药残存量的检测方法和农药安全使用标准显得十分必要且重要。有机氯类农药(OCPs)化学性质稳定,脂溶性大,残效期长,易在脂肪组织中蓄积,造成慢性中毒,严重危及人体健康。由于中成药成分复杂,许多成分的化学结构、理化性质等跟农药极为相似,且剂型多样,使得中成药中OCPs的分离… 相似文献
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采用原子吸收分光光度法测定了十种治疗脑血管疾病的中成药中钙铁铬铅的含量。结果表明,该类中成药中微量元素铁的含量较高,微量元素铅含量较低,该结果为探讨钙铁铬铁元素与治疗脑血管疾病的中成药药效关系提供了有用的数据。 相似文献
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五种补肾中成药物中微量铝分析 总被引:1,自引:0,他引:1
用Al-CAS-OP-10分光光度法测定了五种补肾中成药中铝含量。结果表明,五种中成药中铝含量有一定的差异。本实验结果为进一步研究铝与补肾中成药的功效关系提供了有用数据。 相似文献
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治疗心脑血管疾病中成药中铜锌比值的含量分析 总被引:6,自引:0,他引:6
采用火焰原子吸收分光光度法测定了20种治疗心脑血管疾病中成药物中铜锌含量并计算铜锌比值。结果表明,治疗脑血管疾病中成药中Cu/Zn比治疗心血管疾病中成药中Cu/Zn高,并有含量并计算Cu/Zn一定的差异(P<0.05),这为探讨中成药物中微量元素与治疗心脑血管疾病的关系提供了有用的数据,同时也为临床上合理用药提供了微量元素方面的依据。 相似文献
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色谱指纹图谱法在中草药产地鉴别或中成药鉴别中发挥着重要作用,然而色谱峰强度和位置易受目标物提取和分离条件的影响,发展更加准确的指纹图谱具有重要意义。该文以色谱峰中某一个常见组分(芦丁)作为内标,分析其他组分的相对含量,以相对含量作为指纹图谱信息,结合化学模式识别可以精确给出产地的相似度。以牛舌草的液相色谱指纹图谱指纹峰为例,以其中芦丁的组分峰作为基准峰,其他指纹峰以芦丁为参照,计算每个指纹峰以芦丁计的含量,建立了牛舌草的指纹图谱。将获得的相对含量指纹图谱采用系统聚类分析和主成分分析进行化学模式识别研究,实现了不同产地牛舌草的区分。该方法建立了牛舌草多指标成分的相对定量与鉴别方法,既节省资源,又具有可操作性,对于其他中药或中成药的质量控制具有一定的借鉴意义。 相似文献
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中药质量控制技术发展展望 总被引:6,自引:0,他引:6
本文从中药产业需求、现代化需求、技术需求、机遇与挑战等方面概括了中药质量控制技术发展的背景;讨论了中药质量控制技术对于提高中药药效和安全性、推动产业发展和推进中药国际化的意义;综述了中药质量控制技术的现状,分析了在过程控制、安全性控制、标准品和对照品制备、指纹图谱技术等方面的不足;提出了中药质量控制技术应重点发展以分离和表征技术为主的中药质量控制关键技术、中药安全性控制技术、中药质量控制标准体系、中药质量控制原创性技术和中药标准品、对照品生产技术,制定技术标准,建立具有中药特色的过程控制和产品质量控制标准。 相似文献
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标准物质在检测实验室质量控制中的应用 总被引:1,自引:0,他引:1
【】 本文介绍了检测中使用标准物质进行质量控制的重要意义,分别在盲样测试、期间核查和质量控制图应用方面提出了使用标准物质进行质量控制的三种方法,并通过在实验室获得的检测数据对上述应用方法作了实例说明,对检测实验室应用标准物质进行质量控制工作具有指导意义。 相似文献
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Søren Lykke Christensen Johan Thomas Bonnevie Anglov Jytte Molin Christensen Erik Olsen Otto Melchior Poulsen 《Fresenius' Journal of Analytical Chemistry》1993,345(2-4):343-350
Summary The computer program AMI - Quality Assessment Scheme (AMIQAS) was designed to give easy statistical management of analytical data in relation to method evaluation, internal quality control and proficiency testing. The program is designed in accordance with the recommendation of the ISO 5725 guideline and other official recommendations. The program consists of a database, test for outliers, statistics and graphs for evaluation of an analytical method for chemical, biological and environmental analysis, different control charts to be used in day-to-day internal quality control (Shewhart charts and z-charts). Finally the program has facilities to perform proficiency testing (also called external quality control) and produce the relevant evaluation reports for the documentation of method performance and quality control of results of measurements. The present paper demonstrates the applicability of the AMIQAS program for integrated method evaluation, internal quality control and proficiency testing using the determination of the concentration of lead in human whole blood as the numerical example. 相似文献
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Quality assurance in analytical measurement 总被引:2,自引:0,他引:2
The peculiarities of analytical measurement require to check characteristics of the error (its components) of the obtained
analysis results to assure the quality of the measurements. This article deals with the various quality assurance procedures
and algorithms which are used to check the quality indices, i.e. the accuracy, reproducibility, certainty and repeatability
of analytical measurements: These procedures include: laboratory rapid control; Intra-laboratory statistical control (statistical
selection control by alternative attribute, statistical selection control by quantity method of periodic check of the analysis
procedure for conformity to the specified requirements) and external control (inter-laboratory control checks, inter-laboratory
comparison tests, and intra-laboratory control algorithms carried out by the appropriate supervisory body.) in the separately
taken laboratory. The respective algorithms, control plans and control requirements, specified according to the different
control aims and assurance tasks, enable the quality and certianty of analytical information obtained in laboratories in Russia
to be assured.
Received: 9 November 1998 / Accepted: 24 November 1998 相似文献
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Besides their role as an external quality control tool, PT results or samples could be used as an alternative to fulfil some of the quality assurance requirements such as analytical precision, uncertainty assessment, and internal quality control. This additional use of proficiency testing could help laboratories to reduce the financial impact of their quality assurance process. The purpose of this paper is to highlight some practical uses of PT results or samples in the environmental analytical field, which have been implemented at ISSeP (Institut Scientifique de Service Public), either for method validation or for internal quality control.Presented at the Eurachem PT Workshop September 2005, Portorož, Slovenia 相似文献
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Chromatographic separation techniques and data handling methods for herbal fingerprints: a review 总被引:2,自引:0,他引:2
As herbal medicines have an important position in health care systems worldwide, their current assessment and quality control are a major bottleneck. Over the past decade, major steps were taken not only to improve the quality of the herbal products but also to develop analytical methods ensuring their quality. Nowadays, chromatographic fingerprinting is the generally accepted technique for the assessment and quality control of herbal products. This paper briefly considers the evolution of the regulations and guidelines on the quality control of herbal medicines, and reviews the established analytical techniques for herbal fingerprinting with an emphasis on the most recent developments, such as miniaturized techniques, new stationary phases, analysis at high temperatures and multi-dimensional chromatography. Accessory to the new analytical techniques, the chemometric data handling techniques applied are discussed. Chemometrics provide scientists with useful tools in understanding the huge amounts of data generated by the analytical advances and prove to be valuable for quality control, classification and modelling of, and discrimination between herbal fingerprints. 相似文献
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目前国内铜精矿供应紧俏,铜冶炼行业的原料复杂,有些偏离了认证和认可标准方法的样品,在检测时,用认证、认可文件不能很好地进行质量管控,需要对分析方法加以改进,从技术上进行管控。结合国内铜冶炼企业的实际情况和多年的实践经验,从样品的加工和保存环节、铜分析的技术环节、人员培训、质量抽查、定期开展质量分析会等方面对铜的分析质量控制进行了总结。在具体的质量控制中,针对铜冶炼行业成分复杂、易变化的物料分析,应根据实际情况进行质量管控,以提高铜分析的准确度。 相似文献