共查询到20条相似文献,搜索用时 203 毫秒
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四氢糠基丙二酸二乙酯的新法合成牛福水陈楠周智明*(北京理工大学精细化工教研室100081)四氢糠基丙二酸二乙酯是合成萘呋胺酯草酸盐的重要前体,而萘呋胺酯草酸盐做为一种新型周围血管扩张剂,对脑动脉硬化、脑血栓形成、脑栓塞、耳鸣、头颈损伤及其后遗症有良好... 相似文献
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(1-萘甲基)四氢糠基丙二酸二乙酯的新法合成 总被引:2,自引:1,他引:1
(1-萘甲基)四氢糠基丙二酸二乙酯(Ⅴ)是合成萘呋胺酯草酸盐的重要前体,而萘呋胺酯草酸盐作为一种新型周围血管扩张剂,正受到越来越多的重视[1,2].(1-萘甲基)四氢糠基丙二酸二乙酯(Ⅴ)的原有合成方法[3]产率低,且反应时间长.本文改进了(Ⅴ)的原... 相似文献
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前言丙二酸二乙酯是重要的合成原料,不同取代的丙二酸酯可进一步合成多种不同取代的化合物。烷氧基取代丙二酸酯的合成,文献报导不多。用草酸酯作原料,以醇钠作缩合剂,对于合成脂肪族烷氧基取代的丙二酸酯尚未得到满意的结果。本文进行了正丙氧基丙二酸二乙酯之合成,全部合成过程以反应式表述如下: 相似文献
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Asl? Gök?. ?smail K?rba?lar Hasan Uslu H. Ghanadzadeh Gilani 《Fluid Phase Equilibria》2011,303(1):71-75
Liquid-liquid equilibrium (LLE) data of the solubility (binodal) curves and tie-line end compositions were examined for mixtures of {(water (1) + butyric acid (2) + diethyl succinate or diethyl glutarate or diethyl adipate (3)} at 298.2 K and 101.3 ± 0.7 kPa. The relative mutual solubility of butyric acid is higher in the diethyl succinate or diethyl glutarate or diethyl adipate layers than water layers. The consistency of the experimental tie-lines was determined through the Othmer-Tobias correlation equation. The LLE data were correlated with NRTL model, indicating the reliability of the NRTL equations for these ternary systems. The best results were achieved with the NRTL equation, using non-randomness parameter (α = 0.3) for the correlation. Distribution coefficients and separation factors were measured to evaluate the extracting capability of the solvents. 相似文献
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Jian-Ping Fu 《Journal of fluorine chemistry》2011,132(9):636-640
An efficient and general two-step halogenation procedure to prepare diethyl α,α-bromofluorophosphonates was described, which included bromination by PPh3, 2,3-dichloro-5,6-dicyanobenzquinone (DDQ) and n-Bu4NBr, and electrophilic fluorination by N-fluorobisbenzenesulfonimide (NFSI). Both aromatic and aliphatic α,α-bromofluorophosphonates could be prepared by this method. 相似文献
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The surface tension was investigated with a differential capillary rise method in the temperature range from 273 to 373 K for diethyl carbonate, 278 to 373 K for 1,2-dimethoxyethane, and 293 to 373 K for diethyl adipate, respectively. The uncertainties of the temperature and surface tension were estimated to be within ±10 mK and ±0.2 mN m−1, respectively. A surface tension correlation was developed as a function of temperature with the experimental data, and the average absolute deviations were 0.04, 0.07 and 0.09 mN m−1 for diethyl carbonate, 1,2-dimethoxyethane and diethyl adipate, respectively. 相似文献
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Yossi Zafrani 《Tetrahedron》2009,65(27):5278-5283
A convenient method for the difluoromethylation of phenols and thiophenols, using diethyl bromodifluoromethylphosphonate (1) as a difluorocarbene precursor, is described. This commercially available phosphonate was found to undergo an extremely facile P-C bond cleavage on basic hydrolysis (−78 °C to rt), presumably leading to the bromodifluoromethyl anion, which subsequently converts to a difluorocarbene intermediate. The latter is trapped by phenolates 2 or thiophenolates 3 to give the corresponding difluoromethyl ethers and thioethers in good to excellent yield. The resulting eco-friendly side product, diethyl phosphate ion, is easily separated from the reaction mixture due to its excellent solubility in water. Due to the mild conditions applied to this reaction, phenolate ions bearing carbonyl or enolate functions are selectively difluoromethylated. 相似文献
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Diethyl carbonate has been synthesized via the alcoholysis of ethyl carbamate in supercritical ethanol under catalyst-free conditions.The influences of various parameters such as reaction temperature,reaction time,reaction pressure,ethanol/ethyl molar ratios and reaction loading volume on the yield of DEC were studied systematically.The experimental results indicated that the alcoholysis of ethyl carbamate was greatly improved in supercritical ethanol.The optimal reaction conditions were as follows:a reaction temperature of 573 K,a reaction time of 30 min,a reaction pressure of 13.2 MPa,an ethanol/ethyl carbamate molar ratio of 10 and a reactor loading volume of 285 μL respectively.The optimal yield of DEC was 22.9%. 相似文献
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采用超高效液相色谱法测定化妆品中马来酸二乙酯含量。样品经乙腈超声提取,Waters ACQUITY UPLC HSS T3色谱柱(100mm×2.1mm,1.8μm)分离,乙腈和水为流动相梯度淋洗,在220 nm波长处用二极管阵列检测器检测。马来酸二乙酯的质量浓度在0.50~20 mg·L~(-1)范围内与其峰面积呈线性关系,方法的测定下限(10S/N)为0.5 mg·kg~(-1)。应用此法测定化妆品中两种浓度水平马来酸二乙酯的回收量,方法的平均回收率分别为90.4%和105%,相对标准偏差(n=7)分别为1.5%和3.2%。 相似文献
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A series of arylhydrazines was synthesized from the reaction mixture of Mg powder, 1,2‐dibromoethane, aryl bromide and DEAD (diethyl azodicarboxylate) in THF under ultrasound. This sonochemical Barbier reaction provides an efficient and inexpensive preparation method for synthesis of arylhydrazines. 相似文献
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An efficient synthesis of aryliminophosphoranes is described. A mixture of an aromatic amine, diethyl azodicarboxylate and triphenylphosphine undergo a Mitsonobu type reaction at ambient temperature in dry dichloromethane to afford aryliminophosphoranes in excellent yields. 相似文献
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A concise five step synthesis of the pyrroloquinoline related to makaluvamine, and discorhabdine from 1,2-dimethoxy-3,5-dinitrobenzene is developed. 相似文献
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Novel Bis-β-diketone-type Ligand and Its Copper and Zinc Complexes for Two-photon Biological Imaging
ZHOU Shuang-sheng XUE Xuan WEI Dong JIANG Bo WANG Jia-feng LU Cheng-hua 《高等学校化学研究》2012,28(4):647-651
A curcumin derivative ligand, 1,7-bis(3-methoxyl-4-oxyethylacetate)phenyl-1,6-heptadiene-3,5-diketone (diethyl acetatecurcumin, abbreviated as HL), and its Cu(II) and Zn(II) complexes have been synthesized and characterized by elemental analyses, infrared(IR), 1H NMR and molar conductivity. The experimental results show that the resulting complexes bear strong two-photon excited fluorescence(TPEF) in N,N-dimethyformamide solvent, which has been proven to be potentially useful for two-photon microscopy imaging in living cells. In addition, cytotoxicity tests show that the low-micromolar concentrations of metal-ligand complex(ML2) did not cause significant reduction in cell viability over a period of, at least, 24 h and should be safe for further biological studies. 相似文献