共查询到20条相似文献,搜索用时 421 毫秒
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用邻氨基噻吩腈与不同结构的二羰基化合物反应,合成了新的多取代噻吩并吡啶类衍生物4-氨基-5-取代羰基噻吩并[2,3-b]吡啶-6-酮。用元素分析、红外光谱、核磁共振氢谱和质谱等测试技术对所合成化合物的结构进行了表征。初步生物活性测试表明,该类化合物有较好的杀菌活性和一定的除草活性。 相似文献
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在蓝光照射的无金属、 无添加剂的绿色温和条件下, 以2-氯蒽醌为光催化剂, 空气/氧气为氧化剂, 高选择性地将芳族与杂芳族取代的伯醇和仲醇转化为相应的羰基化合物. 实验结果表明, 该催化剂具有较宽的底物适用范围, 为苄基位含氧化合物的合成提供了一条经济、 环保和可持续的新路径, 具有潜在的应用前景. 相似文献
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Selçuk Gümüş Nezir Aslan Nalan Nuriye Büyükadalı Ayşegül Gümüş 《Tetrahedron: Asymmetry》2017,28(3):479-484
A series of novel chiral hybrid compounds between benzofuran and bicyclic cyclopentenone and also benzothiophene and bicyclic cyclopentenone have been designed and synthesized. Chiral enynes derived from enantiomerically enriched homoallyl and homopropargyl alcohols were converted into bicyclic cyclopentenone structures by intramolecular Pauson-Khand reactions. This strategy provides a facile access to various bicyclic cyclopentenones substituted with benzofuran or benzothiophene ring systems in good yields. In addition to the experimental work, the ground state geometries of the hybrid compounds were optimized using Density Functional Theory applications at the B3LYP/6-31G(d,p) level in order to obtain information about the 3D geometries and electronic structure. 相似文献
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Quinoxaline derivatives have been synthesized in a very short time with excellent yields by the condensation of 1,2-diamines with aliphatic or aromatic 1,2-dicarbonyl compounds or benzilmonoxime in the presence of silica sulfuric acid as a very inexpensive solid acid catalyst at room temperature. The recovery and reuse of the catalyst are also satisfactory. 相似文献
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ACC对羰基化合物、含苄基化合物及稠环芳烃中活泼碳氢键的选择性氧化 总被引:4,自引:0,他引:4
前文曾报道了几种以铵盐或氯化铵为配体与三氧化铬所形成的配合物(CH_3)_3NHCrO_3Cl、(CH_3)_2NH_2CrO_3Cl、CH_3NH_3CrO_3Cl和NH_4CrO_3CI。它们都是高效、温和的醇和肟类选择性氧化剂。其中,NH_4CrO_3Cl(ACC)是最廉价的,具有制备简单、性质稳定、选 相似文献
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《合成通讯》2012,42(2):256-270
AbstractA synthesis of novel hybrid molecules containing thiazole or bis(thiazoles) each bearing benzofuran and/or benzo[d]thiazole moieties by the reaction of the appropriate thioamide derivatives with the corresponding bis-bromoacetyl derivatives is reported. Mono- and bis(triazolothiadiazine) derivatives based on benzofuran or benzo[d]thiazole moieties were also synthesized in good yields by the reaction of the appropriate bis(bromoacetyl) derivatives with each of 4-amino-5-mercapto-1,2,4-triazoles and their corresponding bis-derivatives. 相似文献
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Thomas M. Klapötke Stefan M. Sproll 《Journal of polymer science. Part A, Polymer chemistry》2010,48(1):122-127
Nitrogen‐rich energetic polymers were synthesized by the polyaddition reaction of 1,2‐bis(5‐monomethylhydrazinyl‐1H‐tetrazolyl)ethane ( 1a ), 1‐methyl‐1,2‐bis(5‐monomethylhydrazinyl‐1H‐tetrazolyl)ethane ( 1b ), and 1,4‐bis(5‐mono‐methylhydrazinyl‐1H‐tetrazolyl)butane ( 1c ) with hexamethylene diisocyanate. The experiments showed that neither a polymerization from solution or bulk was possible. Therefore, a new method for the polymerization of tetrazolyl hydrazines had to be developed. The formed polymers were characterized by vibrational spectroscopy (IR) and elemental analysis. The energetic properties were investigated by bomb calorimetric measurements along with calculations using the EXPLO5 software. The thermal stability was investigated by DSC measurements. The properties render the polymers into promising compounds regarding an application as energetic binder. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 122–127, 2010 相似文献
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Suteera Witayakran 《Tetrahedron》2007,63(45):10958-10962
The cascade synthesis of benzofuran derivatives was conducted from the reaction of catechols and 1,3-dicarbonyl compounds via oxidation-Michael addition in the presence of laccase and Sc(OTf)3/SDS. This reaction was carried out under air at room temperature in aqueous medium, and provided benzofuran products in moderate to good yields. In addition, this reaction system showed recyclability. 相似文献
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Ahmed M. Sayed Nader S. Abutaleb Ahmed Kotb Hany G. Ezzat Mohamed N. Seleem Abdelrahman S. Mayhoub Mohamed M. Elsebaie 《Journal of heterocyclic chemistry》2023,60(1):134-144
Exploring the structure–activity relationships (SAR) of a new set of phenylpyrazoles unveiled a potential anti-enterococcus lead compound 12 . The benzofuran moiety linked to the phenylpyrazole 12 was 32 times better than vancomycin against Enterococcus faecalis ATCC 51299. Besides, compound 12 is expected to have an excellent oral bioavailability according to the in silico studies. Of SAR analysis, we found that the benzofuran side chain was essential for the activity. Changing the benzofuran with either benzothiophene, phenyl, pyridinyl, tolyl, or naphthyl reduces/nullifies the pharmacological action. Besides the anti-enterococcal activity, derivatives 4 and 6 can be used to develop new broad-spectrum antibiotics as they exhibited activity against the wild-type highly virulent Escherichia coli isolate. Moreover, compound 13 was proved to show antifungal activity (MIC = 4 μg/ml) against the Candida albicans SS5314 (wild type). Finally, the in silico analysis showed that those compounds have good profiles regarding the absorption, distribution, metabolism, and excretion studies, drug-likeness and pharmacokinetics properties. 相似文献
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Benzothiophene, benzofuran, indole, and indene derivatives are privileged heterocyclic motifs. These are present in a wide range of bioactive natural products and pharmaceutical drugs and are the subject of materials science research. However, the construction of benzothiophene, benzofuran, indole, and indene frameworks have been long‐standing challenges to organic chemists. In this review, we classify the derivatives of four structures synthesized from 2‐benzylidene‐1‐benzofuran‐3‐one and their analogues in terms of their ring size (from three‐ to ten‐membered) and type (fused or spiro), as well as summarizing the developments of this field. Finally, we discuss the ring opening and 1,4‐addition reactions. 相似文献