| 苯并异噻唑啉酮类化合物的合成与活性研究 |
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| 引用本文： | 王向辉,杨建新,游诚航,林强.苯并异噻唑啉酮类化合物的合成与活性研究[J].化学研究与应用,2011,23(10):1290-1294. |
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| 作者姓名： | 王向辉 杨建新 游诚航 林强 |
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| 作者单位： | 1. 昆明理工大学环境科学与工程学院,云南昆明,650093
2. 海南大学教育部热带药用植物化学省部共建实验室,海南海口,570228 |
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| 基金项目： | 国家自然科学基金(20962007)资助项目 |
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| 摘 要： | 通过烷基醇与固体三光气(BTC)反应后加入1,2-苯并异噻唑啉-2(3H)-酮(BIT)继续反应的“一锅法”制备了8种未见文献报道的2-(苯并异噻唑啉-3-酮-2-基)甲酸酯类化合物.化合物结构经IR、1HNMR和元素分析确认,并且对枯草芽孢杆菌、金黄色葡萄球菌、嗜水单细胞菌和大肠杆菌进行了初步抑菌活性实验,实验结果表...
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| 关 键 词： | 1 2-苯并异噻唑啉-2(3H)-酮 合成 抑菌活性 |
Synthesis and biological activity of benzisothiazoleones |
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| WANG Xiang-hui,YANG Jian-xin,YOU Cheng-hang,LIN Qiang.Synthesis and biological activity of benzisothiazoleones[J].Chemical Research and Application,2011,23(10):1290-1294. |
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| Authors: | WANG Xiang-hui YANG Jian-xin YOU Cheng-hang LIN Qiang |
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| Institution: | WANG Xiang-hui1,YANG Jian-xin2,YOU Cheng-hang2,LIN Qiang2(1.Institute of Environmental Science and Engineering,Kunming University of Science and Technology,Kunming 650093,China,2.Key Lab of Tropical Pharmaceutical Herb Chemistry of Hainan Province,Hainan University,Haikou 570228,China) |
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| Abstract: | Eight novel alkyl 3-oxobenzod]isothiazole-2(3H)-carboxylate derivatives were synthesized through reaction of alkyl alcohol with bis(trichloromethy1)car,followed with 1,2-benzisothiazol-2(3H)-one.The structures of these compounds were confirmed by elemental analyses,IR and 1HNMR.Primary antibacterial test against B.subtilis,S.aureus,A.hydrophila,and E.coli showed that most of them had good antibacterial activities.The B.subtilis could be inhibited completely and the inhibition against S.aureus ranged from 7... |
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| Keywords: | 1 2-benzisothiazol-2(3H)-one synthesis antibacterial activity |
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