外腔半导体激光器在高低温下的机械形变与功率变化

外腔激光器具有窄线宽、低功耗的特征,主要用于相干光通信,实际应用中外腔激光器的输出光功率会在环境温度为高温或者低温时出现下降现象。通过使用有限元商用软件Ansys分析,发现高低温下机械结构会有微小的挠度变化,相较于常温,高低温下最大的挠度角度为0.04°。外腔激光器的腔长较长,结合光路仿真软件Zemax研究发现,微小的挠度变化会引起较大的光路变化,影响耦合效率,进而导致输出光功率降低。通过实验量测证实了光路变化,并基于挠度变化引起功率降低的理论,从设计角度提出了通过缩短腔长、加厚基座的方式来减小输出光功率随环境温度的变化。提出的模型与思路可以为类似产品的功率温度相关性分析提供量化分析思路。     

Optical wavelength selection for portable hemoglobin determination by near-infrared spectroscopy method

Hemoglobin concentration is commonly used in clinical medicine to diagnose anemia, identify bleeding, and manage red blood cell transfusions. The golden standard method for determining hemoglobin concentration in blood requires reagent. Spectral methods were advantageous at fast and non-reagent measurement. However, model calibration with full spectrum is time-consuming. Moreover, it is necessary to use a few variables considering size and cost of instrumentation, especially for a portable biomedical instrument. This study presents different wavelength selection methods for optical wavelengths for total hemoglobin concentration determination in whole blood. The results showed that modelling using only two wavelengths combination (1143 nm, 1298 nm) can keep on the fine predictability with full spectrum. It appears that the proper selection of optical wavelengths can be more effective than using the whole spectra for determination hemoglobin in whole blood. We also discussed the influence of water absorptivity on the wavelength selection. This research provides valuable references for designing portable NIR instruments determining hemoglobin concentration, and may provide some experience for noninvasive hemoglobin measurement by NIR methods.     

Multi-optical-wavelength ultrasound-modulated optical tomography: a phantom study

We used multiple optical wavelengths to study ultrasound-modulated optical tomography (UOT) in tissue phantoms. By using intense acoustic bursts and a CCD camera-based speckle contrast detection technique, we observed variations of the ultrasound-modulated signal at various optical absorptions. The experimental variations were found to be highly correlated with predictions from Monte Carlo simulations. By irradiating the sample at two optical wavelengths, we quantitatively estimated the total concentration and the concentration ratio of double dyes in objects embedded in tissue phantoms. The results suggest that UOT can potentially provide noninvasive functional imaging of the total concentration and oxygen saturation of hemoglobin in biological tissue.     

基于连通器原理的小探头光纤液位传感器研究

介绍了以汞包层光波导为传感探头的光纤液位传感器的原理及信号处理,其工作原理是利用连通器将液位的变化转变为汞包层光波导包层长度的变化。理论分析和实验表明,当光波导直径和光波长一定时,光功率衰减随汞包层光波导长度增加作线性增加。通过对汞包层光波导引起光功率衰减的检测,探头结构的优化设计以及探测器件的选型,可以获得实时性很强的高精度液位测量。实验测得10m液位的最大测量误差为5．2mm,理论分析的相对测量精度可达0．02％。该液位传感器的研制对于油库等易燃、易爆环境中的液位测量具有重要意义。     

Oxyhemoglobin saturation measurements by green spectral shift

From an analysis of new hemoglobin solution transmission spectra at various oxygen saturations (SO2), path lengths, and pH, we find the determination of SO2 by using the classical oximetry technique to be poorly calibrated. We used this data set to develop a proposed method for SO2 determination based on the spectral shift of the hemoglobin transmission minimum between 475 and 510 nm. The method does not require accurate knowledge of hemoglobin extinction coefficients and is linear in relation to SO2 despite changes in path length, pH, or hemoglobin concentration.     

Correlative studies in optical reflectance measurements of cerebral blood oxygenation

A numerical study is made of correlation development for measuring cerebral blood oxygen saturation (StO) noninvasively using optical reflectance ratio of dual wavelengths. The Monte Carlo (MC) method was used for simulating reflectance measurements in a model neck tissue, where the cerebral blood oxygenation was monitored through the blood flows in the common carotid artery (CCA) and jugular vein. Reflectance ratios between two wavelengths at 633 and 800 nm were obtained under different blood vessel conditions. The results revealed a quantifiable correlation between the reflectance ratio and the cerebral StO level. Correlations for each of the blood vessel parameters such as the location, size, and hemoglobin concentration of the CCA or jugular vein (JV) were developed.     

Evidence specifically favoring the equalization-cancellation theory of binaural unmasking

Three experiments investigated the roles of interaural correlation (rho) and of the monaural power spectrum in the detection and discrimination of narrow-band-noise signals (462-539 Hz) in broadband maskers (0-3 kHz). The power and rho of the target band were independently controlled, while the flanking noise was fixed and diotic. Experiments 1 and 2 involved rho and power values that would be produced by specific values of signal-to-noise ratio (SNR) in the NoSpi binaural configuration. Listeners were required to discriminate different SNRs via a 2I-FC loudness-discrimination task. At low reference SNRs, changes in rho fully accounted for listeners' performance, but as reference SNR increased, additional energy in the target band played an increasing role. Experiment 2 showed that at these higher SNRs the combination of information from the power spectrum and rho was superadditive and could not be explained by simple signal-detection models. The equalization-cancellation (EC) theory would explain these data using the output from interaural cancellation, Y, rather than rho. Experiment 3 attempted to foil binaural processing, by fixing either rho or Y across intervals. Consistent with EC theory, when Y was fixed, the contribution of the binaural system appeared negligible, while fixing rho did not have this effect.     

Micro double tapered optical fiber sensors based on the evanescent field-effect and surface modification

A double tapered optical fiber sensor based on evanescent field-effect and surface modification technology was introduced in this work. Whether the liquid and gas molecules had polarities or not, they all could be detected by the sensors modified in different silane coupling agents. At the same time, the sensing characters of the single mode optical fiber with three different tapering lengths were researched, and it came to a conclusion that the optical fiber sensor had stronger evanescent field effect and higher sensitivity when length of tapered fiber was 30 mm. The functionalized tapered fibers modified by 3-aminopropyltrimethoxy silane (APTES) or 3-methylpropenylacyloxy propyltrimethoxy silane (MPAPTES), were employed to detect the polar or nonpolar molecules which had corresponding features. Further, the results of quantitative tests showed that the fiber optic sensor was sensitive to the change of the ethanol concentration and the characteristic peaks of the absorption power spectra could reach to 3–5 dB.     

In vivo near-infrared spectral detection of pressure-induced changes in breast tissue

A diffuse near-infrared tomography system was used to measure dynamic changes in the absolute optical properties of the human breast that were induced through pressure applied to the tissue surface. Results from five subjects show that absorption and scattering coefficients changed measurably when pressure was increased and that these relative changes correlated with the subjects' body-mass index, indicating that the effect depends on tissue composition. Fitting the absolute absorption and scattering coefficients at six wavelengths to the molar absorption spectra of the three predominant chromophores revealed that both the average total hemoglobin and oxygen saturation increased by 10%, while water concentration decreased by more than 12%. These changes indicate that the pressure-induced variation is likely due to water displacement and vascular volume increase in the region being imaged, for mild application of pressure to the breast. These results suggest that the pressure applied during optical measurements of tissue may alter the tissue physiology, and care should be taken to factor this effect into the design of optical medical instrumentation. In addition, the technique provides a unique approach to measuring tissue elastic changes in vivo in the female breast and may offer a new method for dynamic contrast imaging based on elasto-optical measurements.     

激光致晶态Ag11In12Te26Sb51相变介质光学常数的研究

研究了结晶度对Ag11In12 Te2 6Sb51相变薄膜光学常数的影响。用初始化仪使相变薄膜晶化 ,改变晶化参量得到不同的结晶度 ,当转速固定时 ,随激光功率的增加 ,折射率基本随之减小 ,消光系数先是增大 ,而后减小 ;当激光功率固定时 ,随转速的增大 ,折射率也随之增大 ,消光系数也是先增大后减小。非晶态与晶态间的变换、薄膜微结构的变化 (包括晶型的转变和原子间键合状态的变化 )以及薄膜内残余应力是影响Ag11In12 Te2 6Sb51相变薄膜复数折射率的主要原因。测量了单层膜的透过率和CD RW相变光盘中Ag11In12 Te2 6Sb51薄膜非晶态和晶态的反射率     

Influence of a skull cranial window on the measurement of haemoglobin concentration in cortical tissue by multi-spectral imaging analysis

The simplified cranial window, which is transparent thinned skull, has been used for the optical imaging of cortical tissue of small animals to measure the concentration change in haemoglobin as an intrinsic signal of brain activation. The multi-spectral images of the cortical tissue of guinea pigs through the skull cranial window were compared with those of the exposed cortex to evaluate the influence of the scattering and absorption properties of the skull on the measurement of the concentration change in haemoglobin. Although skull thickness affects the sensitivity of the optical signal due to a decrease in mean optical path length in the cortical tissue, the influence of the skull cranial window on the wavelength dependence of optical path length can be ignored when the skull thickness is less than approximately 100 mm. Accurate concentration changes in oxygenated and deoxygenated haemoglobins can be calculated from the optical signal measured through a skull cranial window and the wavelength dependence of optical path length for the exposed cortex.     

In vivo integrated photoacoustic and confocal microscopy of hemoglobin oxygen saturation and oxygen partial pressure

We developed dual-modality microscope integrating photoacoustic microscopy (PAM) and fluorescence confocal microscopy (FCM) to noninvasively image hemoglobin oxygen saturation (sO?) and oxygen partial pressure (pO?) in vivo in single blood vessels with high spatial resolution. While PAM measures sO? by imaging hemoglobin optical absorption at two wavelengths, FCM quantifies pO? using phosphorescence quenching. The variations of sO? and pO? values in multiple orders of vessel branches under hyperoxic (100% oxygen) and normoxic (21% oxygen) conditions correlate well with the oxygen-hemoglobin dissociation curve. In addition, the total concentration of hemoglobin is imaged by PAM at an isosbestic wavelength.     

Spectral studies of photomodification of blood by therapeutic doses of optical radiation at different wavelengths

We analyze changes in electronic and IR absorption spectra of samples of blood and its components, in the fluorescence spectra of plasma, as well as in the gas composition of blood, the hemoglobin concentration, and acid-base balance indices, upon the irradiation of blood by therapeutic doses of optical radiation at 254, 632.8, 670, and 806 nm. We show that the irradiation of blood by radiation at these wavelengths initiates similar molecular changes in blood and its components and that monochromatic incoherent light acts equally as efficiently as laser radiation. We find that, if the blood irradiation wavelength is in the range of the absorption bands of hemoglobin, the hemoglobin acts as a primary photoacceptor and that the dissociation of hemoglobin complexes with ligands directly in erythrocytes is a primary photoprocess. We conclude that the photomodification of blood should be attributed to therapeutic methods capable of controlling the balance between the production of active forms of oxygen and their inhibition by antioxidant systems of the organism.     

二极管泵浦准三能级板条固体激光器的优化设计

基于最大激光增益条件，分析和优化了二极管泵浦准三能级Yb∶YAG固体板条激光器的激光增益、板条的最佳光学长度和最佳宽度参数。结果表明：在低功率侧面泵浦条件下，板条增益介质的掺杂浓度和板条宽度满足一定的关系，这为研究该类激光器提供了一条有效途径，其结果可应用于其他准三能级固体激光器设计。     

薄膜厚度对AgInSbTe相变薄膜的光学性质的影响

采用射频溅射法制备了Ag8In14Sb55Te23相变薄膜,对深积态薄膜在300℃时进行了热处理,测量了不同厚度薄膜的反射、吸收谱及光学常数。研究了薄膜的光学常数与薄膜厚度的关系。结果表明在一定的厚度范围其光学常数随膜层厚度的不同有较大的变化,尤其在短波长范围内更为明显,这对于短波长记录相变光盘有重要意义。     

Wavelength tuning in Er3+,Yb3+:glass microchip lasers

The paper presents the investigation results of laser generation around 1.5 μm at different wavelengths. The shifts of the wavelength were achieved by the change of pump power, transmission of an output mirror, and length of an active medium. Mathematical analysis and explanation of this phenomenon was curried out on the basis of the change in relation between the gain and loss lines.     

Stable multiwavelength fiber ring laser with equalized power spectrum based on a semiconductor optical amplifier

We experimentally demonstrated a new structure of a multiwavelength semiconductor optical amplifier (SOA) ring laser based on a fiber Sagnac loop filter that can generate up to 25 stable output lasing wavelengths at room temperature. By varying the length of a polarization-maintaining (PM) fiber within the Sagnac loop filter, the wavelength spacing between the output lasing wavelengths can be changed to a desired value. By tuning a polarization controller (PC) within the Sagnac loop filter, stable multiwavelength 1550-nm operation with up to 17 lasing lines within 3 dB power level variation and with a wavelength spacing of ∼0.8 nm was achieved. The optical signal-to-noise ratios (OSNRs) of all the lasing wavelengths are greater than 40 dB.     

Demodulation of micro fiber-optic Fabry–Perot interferometer using subcarrier and dual-wavelength method

Subcarrier technology and dual-wavelength demodulation method are combined for tracking the cavity length variation of a micro fiber-optic Fabry–Perot (F–P). Compared with conventional dual-wavelength demodulation method, two operation wavelengths for demodulation are modulated with two different carrier frequencies, respectively, and then injected into optical link connected with the F–P cavity. Light power reflected for the two wavelengths is obtained by interrogating the powers of Fast Fourier Transform (FFT) spectrum at their carrier frequencies. Because the light at the two wavelengths experiences the same optical and electrical routes, measurement deviation resulting from the drift of optical and electrical links can be entirely eliminated.     

Character analysis of slow light with communication waveband in fiber optical parametric amplifier

The comprehensive characters of delay time and delay bandwidth with distortion, signal wavelength dependence and delay bandwidth product in fiber optical parametric amplifier are investigated theoretically when the pump locates at anomalous dispersion region. The delay character of single pulse, data stream with certain bit pattern and pseudo random data stream are analyzed comprehensively. In this category of fiber optical parametric amplifier, the delay time and delay bandwidth product vary from signal wavelengths and bit rates. For the same nonlinear coefficient, pump power and fiber length, the diverse dependences of bit pattern in different signal wavelengths are found by numerical simulation. The impacts of pump power and fiber length on the delay character and distortion are also discussed. These relations are conductive to the design of slow light based on fiber optical parametric amplifier in telecommunication waveband.     

基于近红外光谱的SG-MSC-MC-UVE-PLS算法在全血血红蛋白浓度检测中的应用

为提高全血血红蛋白浓度预测模型的预测精度,基于近红外光谱分析,首先对原始全血透射光谱数据分别进行均值中心化、标准化、标准正态变量变换(SNV)、多元散射校正(MSC)以及Savitzky-Golay（SG）卷积平滑结合MSC的预处理操作,最终选择预处理效果最好的SG-MSC方法作为数据预处理方法,其最大相关系数达到0.944 1。对SG平滑的平滑窗口宽度进行讨论,找出平滑效果最好的窗口宽度为27。数据预处理消除了全血吸收光谱的基线失真,提高了全血吸收光谱数据的信噪比。将190个样本（190个血红蛋白浓度对应的透射光谱数据）分为具有相近血红蛋白浓度分布的校正集和测试集,其中校正集为143个样本（对应血红蛋白浓度分布为10.6～17.3 g·dL-1）,测试集为47个样本（对应血红蛋白浓度分布为10.3～17.3 g·dL-1）,确保建立模型的适用性。对校正集数据预处理后利用蒙特卡洛无信息变量消除（MC-UVE）方法对其进行波长变量选择,剔除含信息量少的波长点,提高含信息量多的波长占比。设置蒙特卡洛迭代次数为1 000,最终从全血吸收光谱的700个波长变量中筛选出191个波长变量用于建立全血血红蛋白浓度偏最小二乘（PLS）回归模型。对比分析原始全血透射光谱全谱PLS模型、原始全血吸收光谱全谱PLS模型、预处理全血吸收光谱全谱PLS模型、SG-MSC-MC-UVE-PLS模型以及已有二阶导数PLS模型的模型效果,表明基于SG-MSC-MC-UVE-PLS算法的全血血红蛋白浓度预测模型效果较其他模型效果更优,预测相关系数由0.676 3提高到0.979 1,预测集均方根误差由0.898 1减小到0.220 3,最大绝对误差由2.426 1减小到0.411 2。同时,利用MC-UVE方法进行波长变量选择,在保证预测精度的前提下,筛选出建模的波长个数更少,有利于提高模型计算效率。研究结果表明,SG-MSC-MC-UVE-PLS方法能够提高全血吸收光谱信号的信噪比,简化模型结构,提高模型的预测精度和计算效率,对推动血红蛋白浓度检测技术的发展具有进步意义。