政府监管下的医院医疗信息分享演化博弈分析

在分析政府监管下医院间医疗信息分享特征的基础上,结合我国当前正在推行的医联体医院间信息分享运作模式,引入梅特卡夫定律并考虑患者评价的影响,分析了监管部门与医院各自的利益组成,建立了监管部门与医院两者之间的演化博弈模型,并采用复制动态方程研究了不同情形下医院间信息分享的演化博弈轨迹。研究表明,政府通过监管并建立激励惩罚机制等引导措施对医院最终达到的演化稳定态具有极大影响;降低医院主体信息分享的风险成本、规范提高医院分享信息的质量、引导患者增强对医院信息分享的关注、制定有吸引力和威慑力的奖惩政策,是促进医院医疗信息分享的关键。研究结果可为政府监管部门预测医院间的信息分享趋势和制定精准化政策以促进分享提供参考。     

基于演化博弈的公共交通、共享汽车与私家车的博弈分析

出行者的选择行为分析是交通系统中的一项重要内容,随着城市的发展,交通出行方式大体分为三大类:公共交通出行、辅助公共交通出行和私人交通出行。本文在以往的研究基础上,采用演化博弈的方法研究公共交通、共享汽车以及私家车三者之间的博弈关系,模拟出行者的选择行为,分析博弈均衡点稳定性及参数条件。通过模型仿真实验,演化结果中各项比例大小取决于各项收益、补贴、损失以及额外收益,要增加公共交通的配套设施,增收拥堵费以及增加对共享汽车的补贴及配套服务。     

生产率差异与企业对外直接投资进入模式选择

基于企业异质性视角,借鉴演化博弈理论探究企业通过OFDI“走出去”时的跨国并购方和标的方在全要素生产率上的差异对企业OFDI进入策略选择的影响机制。利用Hotelling模型构造资本密集型企业与劳动密集型企业OFDI进入策略选择博弈模型,讨论两类企业OFDI进入方式决策在并购双方生产率差异变化之下的变迁机理。研究发现:当并购方和被并购方生产率差异较小时,市场达到两类企业都倾向于跨国并购策略的演化稳定状态;当并购双方生产率差异较大时,企业的生产要素密集度及其结构对其OFDI进入模式决策具有重要的作用,知识或技术密集度较高的资本密集型企业与综合实力强势的部分劳动密集型企业采取跨国并购战略,而另一部分劳动密集型企业选择绿地新建方式进入国际市场。即企业OFDI进入策略选择因其所属的行业生产要素密集度及其结构不同而具有差异性。研究结论在一定程度上弥补了现有研究的不足,为以后的研究工作提供一定的理论参考。     

The Fundamental Equations of Change in Statistical Ensembles and Biological Populations

A recent article in Nature Physics unified key results from thermodynamics, statistics, and information theory. The unification arose from a general equation for the rate of change in the information content of a system. The general equation describes the change in the moments of an observable quantity over a probability distribution. One term in the equation describes the change in the probability distribution. The other term describes the change in the observable values for a given state. We show the equivalence of this general equation for moment dynamics with the widely known Price equation from evolutionary theory, named after George Price. We introduce the Price equation from its biological roots, review a mathematically abstract form of the equation, and discuss the potential for this equation to unify diverse mathematical theories from different disciplines. The new work in Nature Physics and many applications in biology show that this equation also provides the basis for deriving many novel theoretical results within each discipline.     

The cultural Red King effect

Why do minority groups tend to be discriminated against when it comes to situations of bargaining and resource division? In this article, I explore an explanation for this disadvantage that appeals solely to the dynamics of social interaction between minority and majority groups—the cultural Red King effect (Bruner, 2017). As I show, in agent-based models of bargaining between groups, the minority group will tend to get less as a direct result of the fact that they frequently interact with majority group members, while majority group members meet them only rarely. This effect is strengthened by certain psychological phenomenon—risk aversion and in-group preference—is robust on network models, and is strengthened in cases where preexisting norms are discriminatory. I will also discuss how this effect unifies previous results on the impacts of institutional memory on bargaining between groups.     

Computational analysis for the determination of deleterious nsSNPs in human MTHFD1 gene

Single nucleotide polymorphisms (SNPs) are the most common genetic polymorphisms and play a major role in many inherited diseases. Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) is one of the enzymes involved in folate metabolism. In the present study, the functional and structural consequences of nsSNPs of human MTHFD1 gene was analyzed using various computational tools like SIFT, PolyPhen2, PANTHER, PROVEAN, SNAP2, nsSNPAnalyzer, PhD-SNP, SNPs&GO, I-Mutant, MuPro, ConSurf, InterPro, NCBI Conserved Domain Search tool, ModPred, SPARKS-X, RAMPAGE, FT Site and PyMol. Out of 327 nsSNPs form human MTHFD1 gene, total 45 SNPs were predicted as functionally most significant SNPs, among which 17 were highly conserved and functional, 17 were highly conserved and structural residues. Among 45 most significant SNPs, 15 were predicted to be involved in post translational modifications. The p.Gly165Arg may interfere in homodimer interface formation. The p.Asn439Lys and p.Asp445Asn may interfere in binding interactions of MTHFD1 protein with cesium cation and potassium. The two SNPs (p.Asp562Gly and p.Gly637Cys) might interfere in interactions of MTHFD1 with ligand.     

On an initial boundary value problem in nonlinear 3D-magnetoelasticity

We prove existence and uniqueness of a weak solution to an initial boundary value problem, related to the Maxwell and Lamé systems nonlinearly coupled through the so-called magnetoelastic effect. Uniqueness is proved under additional assumptions on the smoothness of the solution.     

用反向渐进结构优化方法研究洞室支护优化

洞室开挖支护的优化是在铁路隧道、矿山开挖、水电站建设中经常面对的课题,特别是研究洞室开挖支护拓扑优化有着重要的意义。本文利用近年来发展的渐进优化方法(ESO)的概念,提出了反向ESO方法的迭代格式,建立了洞室开挖支护优化的准则及其敏感度,研究了均匀地基不同地应力条件使得开挖卸荷产生的总应变能最小的最优支护拓扑。结果证明了反向ESO方法的适用性,最优支护拓扑大致成椭圆或者圆形,其主轴方向与最大主应力主轴方向相同。     

预应力索-桁架结构形状优化设计

就预应力索-桁架结构形状优化设计问题,考虑了施加预应力阶段、预应力与荷载共同作用阶段的性态约束条件,建立了设计变量包括截面尺寸、索力值、杆件及索节点坐标的形状优化数学模型;在求解方法上将设计变量分为两个子空间:第一子空间为索力值和截面尺寸优化设计空间,第二子空间为形状优化设计空间; 第一子空间给出新的求解方法以减轻结构重量,第二子空间用节点渐进法优化结构形状和布索位置以增加结构刚度.算例表明,该方法能使结构重量逐步减轻,结构刚度不减,形状逐步达到最优.     

Lee极值原理与结构的大挠度塑性动力响应

本文介绍了利用Lee 极值原理确定结构的大挠度塑性动力响应的数值方法,给出了在均布冲击载荷作用下的理想刚塑性门形框架的大挠度进化模态解,指出如果模态形式取得合适,可使进化模态解接近于真实解.这样得到的门形框架的大挠度模态解与文献[8]中的实验结果和文献[9]中的大挠度完全解都符合得很好.