Detection system for singlet oxygen luminescence in photodynamic therapy

Singlet oxygen （^1O2） is widely considered to play a major role in photodynamic therapy （PDT）, and thus an increasing attention has been focused on the direct detection of ^1O2 near-infrared luminescence around 1270 nm for PDT dosimetry. A new sensitive detection system is developed to directly measure the temporal and spectral resolved ^1O2 luminescence spectra. The triplet state and ^1O2 lifetimes of Rose Bengal as a model photosensitizer in different solvents are determined, and the obtained results agree well with the published data. Our detection system has the potential application in ^1O2 luminescence-based PDT dosimetry.     

窄带紫外LED照射对大鼠骨代谢的影响

背景：紫外线是维持骨骼健康的关键条件之一，但由于传统的紫外线光谱较宽，在骨质疏松症领域并未引起足够的重视。材料与方法：在研究中，建立了一种新设计的窄带光谱LED器件，以研究紫外LED对骨质疏松大鼠骨代谢、骨形态和皮肤的影响。共设置了去卵巢大鼠（n=24）和去卵巢大鼠（n=36）。然后将去卵巢大鼠分为假手术组（Sham，n=12）和检测模型组（Sham，n=12)。将去卵巢大鼠分为LED照射组（LED，n=12）、未处理组（OVX，n=12）或检测模型组（OVX，n=12）。LED 辐照参数（0.8 mW·cm-2，1 000 s，每周两次）。结果：与假手术组相比，维生素D、mRNA、血清ALP、血清25(OH)D₃、血清P1NP的表达明显升高，血清PTH和血清TRAP的表达明显降低。大鼠皮肤照射前后p53基因未见明显变化。结论：研究结果表明，新型紫外 LED 器件照射可显着提高血液中 25(OH)D₃ 水平，促进骨形成，抑制骨吸收，且对大鼠皮肤无不良影响。     

倾斜潮汐分析及海潮负荷效应

本文采用引潮势、太阳热辐射能流和引力潮的非线性效应作为输入函数,同时提出以海潮潮族作为海潮负荷效应的输入函数对一年实测的倾斜潮汐进行总体响应分析,将频率相同的倾斜引力潮、负荷潮、辐射潮和非线性潮分离开。另外还以j,v模型对倾斜潮汐和分离开的各部分倾斜潮进行了调和分析,进而计算其旋转椭圆要素。     

The Analyses of the Tilt Tides and the Loading Effect of Ocean Tides on the Tilt Tides

Using tidal potential solar thermal-radiating energy current and the nonlinear effect of the gravity tide as the input function, moreover, considering the ocean tidal species as the input function of the loading effect of ocean tide, we make the lumped response analysis of the observational tilt tide in one year. The tilt gravitational tide, the load tide, the radiational tide and the nonlinear tide with the same frequeny are separated off. It is shown that the load tide and the gravitational tide are the same quantity grade, the load tide may spread into inland far away; the solar thermal-radiation has an effect on the tilt tide; there is a little nonlinear tide in the tilt tide, but the nonlinear tide of the ocean tide has the stronger loading effect on the tilt tide than the nonlinear tide brought about by the gravitational tide itself; the lag interval, △τ=41 (h), is the best value in the response analysis. In addition, the harmonic analyses of the tilt tide and the separated tilt tides are made r     

稀土氮杂大环多羧酸配合物Na［Ln（DOTMA）（H_2O）］·2H_2O的合成与表征

稀土氮杂大环多羧酸配合物Ｎａ［Ｌｎ（ＤＯＴＭＡ）（Ｈ_２Ｏ）］·２Ｈ_２Ｏ的合成与表征陈德福，金天柱（北京大学稀土材料化学及应用国家重点实验室，北京，１００８７１）关键词稀土，氮杂大环多羧酸，配合物核磁共振成像技术已成为肿瘤和其它病变组织的临床诊断及生...     

三乙四胺六乙酸钆配合物的合成及晶体结构

在水溶液中合成了三乙四胺六乙酸钆配合物:K4[Gd2(HTTHA)2].14H2O的单晶, 并测定了其结构。晶体属单斜晶系, P21/n空间群。晶胞参数: a=1.1266(5)nm,b=2.5686(4)nm, c=2.2076(8)nm, β=102.50(3)°,V=6.237(6)nm^3, Z=4, Dc=1.812g/cm^3。配合物是比核分子,每个钆离子与来自同一个三乙四胺六乙酸的3个氮原子和4个羧基氧原子, 来自另一个三乙四胺六乙酸的2个羧基氧原子配位,形成三冠三角棱柱型配位多面体。