1,4-戊二烯-3-酮肟醚类化合物的合成及生物活性

将1,4-戊二烯-3-酮结构中的羰基转变为肟醚基团,合成了7个1,4-戊二烯-3-酮肟醚类化合物,其结构经1H NMR、13C NMR、IR和ESI-MS表征。生物活性测试结果表明,在药剂浓度为500mg/L时,化合物4c、4f和4g对烟草花叶病毒(TMV)在治疗作用方面的抑制率为49.6%、53.6%和47.4%,与病毒唑(45.2%)相当;化合物4b、4c、4f和4g对TMV在保护作用方面的抑制率分别为57.2%、58.4%、58.9%和59.0%,稍低于病毒唑(61.8%);化合物4a、4b、4c和4g对TMV在钝化作用方面的抑制率分别为95.5%、92.6%、95.0%和89.5%,优于对照药病毒唑(87.9%)。这些结果表明,1,4-戊二烯-3-酮肟醚类化合物对植物病毒表现有良好抑制作用,在其结构基础上进行适当的优化,有望得到具有良好抗植物病毒活性的先导化合物。     

THERMODYNAMIC AND PARTICLE-DYNAMIC STUDIES ON SYNTHESIS OF SILICA NANOPARTICLES USING MICROWAVE-INDUCED PLASMA CVD

1. Introduction1.1 Silica nanoparticles and synthesis methods Silica (SiO2) nanoparticles are widely used in industry asan active filler for polymer reinforcement, a rheologicaladditive in fluids, a free flow agent in powders, and anagent for chemical mechanical polishing during IC (inte-grated circuit) fabrication (Sniegowski & de Boer, 2000).Silica powder is also used for producing silicon carbide(Koc & Cattamanchi, 1998) or opaque silica aerosols (Leeet al., 1995). Many methods can …     

OFDMA中继系统中基于QoS保证的资源分配算法

研究了 OFDMA 中继下行链路通信系统中的动态资源分配问题,提出了一种可以保证用户最低 QoS 需求的资源分配算法.首先在简化资源优化问题的过程中,采用等功率分配方法以降低算法复杂度,然后通过拉格朗日松弛优化方法推导出了子载波分配和中继选择最优解,并在此基础上引入用户速率权衡因子,根据速率权衡因子越大的用户,越具有选择子载波和中继的优先权这一准则进行子载波分配和中继选择.仿真结果表明:新算法能够获得较高的系统容量,同时也能很好地保证不同用户的最低速率需求.     

超声提取-气相色谱-质谱法同时测定尼龙等食品接触材料中5种酰胺类物质

对超声提取法从尼龙等食品接触材料中分离出5种酸胺类物质(丙烯酰胺、甲基丙烯酰胺、己内酰胺、油酸酰胺和硬脂酰胺)的条件进行了优化。预先将所分析的材料洗净晾干,剪成0.5cm×0.5cm的小块,并混匀。取此样品1.00g,用甲醇先后提取2次,每次加甲醇25mL,于25℃超声提取30min。将提取后过滤所得滤液合并,在45℃吹氮至近干。残渣用甲醇溶解并定容至50.0mL。取此溶液1.0mL,用0.22μm滤膜过滤,取其滤液按仪器工作条件进行气相色谱-质谱分析。选用Agilent HP5-MS色谱柱及在60～270℃区间按程序升温模式进行色谱分离,并按5种酰胺化合物的保留时间进行质谱测定。上述5种酰胺的质量浓度均在5～100mg·L~(-1)内与其对应的峰面积呈线性关系。测得其检出限(3S/N)为0.08～1.0mg·L~(-1)。以空白样品为基体,加入5种酰胺的混合标准溶液进行回收试验,测得回收率为90.2%～104%,测定值的相对标准偏差(n=6)为0.78%～1.7%。按本方法分析了4件实样,结果仅在尼龙炊具中检测到已内酰胺,质量分数为10mg·kg~(-1),小于欧盟规定的迁移限量(15mg·kg~(-1))。     

Synthesis and gelation behaviors of five new dimeric cholesteryl derivatives

Five new diacid amides of di-cholesteryl L-glycinates were designed and prepared.The compounds with linkers containing 0,1, 2,3,or 4 methylene units are denoted as 1,2,3,4,and 5,respectively.Their gelation behaviors in 25 solvents were tested as novel low-molecular-mass organic gelators(LMOGs).It was shown that the length of the linker connecting the two-cholesteryl residues in a gelator plays a crucial role in the gelation behavior of the compound.1 gels 11 of the 25 solvents tested at a concentration lowe...     

CHARACTERIZATIONS AND RELATIONSHIPS BETWEEN OUTDOOR AND INDOOR BIOAEROSOLS IN AN OFFICE BUILDING

1.IntroductionBioaerosolsaremicroorganismsorparticles,gases,vapors,orfragmentsofbiologicalorigin(i.e.,aliveorreleasedfromalivingorganism)thatexistintheair.Bioaerosolsareeverywhereintheenvironment.Underfavorableconditions,bioaerosolsareabletogrowandpropagateonavarietyofbuildingmaterialsandindoorsurfaces,causingindoorairpollution.Therefore,owingtotheirubiquitouspresenceinnature,bioaerosolsasapollutionsourcearealmostinevitableinarangeofenclosedenvironmentsandincommunityair(Kodama&McGee,1986;Lig…     

A Trinuclear Ni(Ⅱ) Mixed-ligand Complex Containing Pentadentate N-butylsalicylhydrazide and Monodentate Imidazole:Synthesis, Characterization and Crystal Structure

A novel trinuclear nickel(Ⅱ) complex [Ni3(bushz)2(Himdz)2(H2O)2]?2DMF (1, bushz=N-butylsalicylhydrazide, Himdz=imidazole, DMF=N,N-dimethyl-formamide) has been synthesized and characterized by X-ray single-crystal diffraction characterization. Complex 1 crystallizes in the monoclinic system, space group P21/c with a=7.706(7), b=14.882(6), c=18.639(6) , β=108.08(2)o, V=2032(1) 3, Dc=1.525 g/cm3, Mr=932.95, Z=2, F(000)=972, μ=1.442 mm-1, the final R=0.0359 and wR=0.0771. The three nickel(Ⅱ) atoms in 1 are arranged in a strictly linear structure and exhibit alternating square-planar and octahedral geometries. The complex is connected to form a supramolecule with an infinite three-dimensional network through intermolecular hydrogen bonds. The electrochemical studies reveal that redox of Ni3+/Ni2+ in the complex is a quasi-reversible process. The thermal stability of the title complex was also studied.