A series of ionic liquids (ILs) based on nitrile-functionalized imidazolium, pyridinium, and quaternary ammonium as cations and chlorides and tetrafluoroborate, hexafluorophosphate, dicyanamide, and bis(trifluoromethanesulfonyl)imide as anions have been prepared and characterized. The physicochemical properties such as spectroscopic, thermal, solubility, surface, electrochemical, tribological, and toxic properties were comparatively studied. The results showed that the incorporation of a CN group to cations could result in remarkable changes in these properties. The reason resulting in such remarkable differences in the properties may be attributed to the conformational changes in the imidazolium groups caused by the interaction between the CN group with other neighboring cations or anions and the enhancement in hydrogen-bonding interactions due to the incorporation of a CN group. 相似文献
Two new series of diaryl thiourea containing sorafenib derivatives 9a – 9t were designed and synthesized, and their antiproliferative activities against PC‐3, HCT116 and MDA‐MB‐231 cell lines were evaluated. All compounds generally showed antiproliferative activity to PC‐3 cells, most of the analogs exhibited potent antiproliferative activity to HCT116 cells, and compounds 9e , 9f , 9o and 9p demonstrated inhibitory activities against all three cell lines. The structures of all the newly synthesized compounds were determined by 1H NMR, 13C NMR and HRMS. 相似文献
A new series of ionic liquids composed of three cyclic sulfonium cations and four anions has been synthesized and characterized. Their physicochemical properties, including their spectroscopic characteristics, ion cluster behavior, surface properties, phase transitions, thermal stability, density, viscosity, refractive index, tribological properties, ion conductivity, and electrochemical window have been comprehensively studied. Eight of these salts are liquids at room temperature, at which some salts based on [NO3]? and [NTf2]? ions exhibit organic plastic crystal behaviors, and all the saccharin‐based salts display relatively high refractive indices (1.442–1.594). In addition, some ionic liquids with the [NTf2]? ion exhibit peculiar spectroscopic characteristics in FTIR and UV/Vis regions, whilst those salts based on the [DCA]? ion show lower viscosities (34.2–62.6 mPa s at 20 °C) and much higher conductivities (7.6–17.6 mS cm?1 at 20 °C) than most traditional 1,3‐dialkylimidazolium salts. 相似文献
Factoring business, an important aspect in the supply chain finance field, has significant potential in adopting blockchain-based intelligent contract technology. Based on the existing theories of factoring business in supply chains, this paper conducts a coupling analysis between blockchain technology and supply chain factoring business. Specifically, we propose the application scenarios of blockchain-based intelligent contract technology in the supply chain factoring business from three aspects: the division and transfer of creditors’ rights certificate, the factoring financing of upstream suppliers, and the due payment of core enterprises, and elaborate their implementation processes. Furthermore, from a game theoretical perspective, we analyze the mechanism of the key technology implementation of the intelligent contract to verify whether the nodes on the blockchains will follow the relevant protocols to automatically execute them. Finally, we conduct a three-way game analysis of the supply chain factor financing process and obtain an equilibrium solution based on the principle of utility maximization, which highlights the optimization effect of the intelligent contract technology on the decision-making behavior of individual entities in the supply chain.
A series of flavonoids were isolated from Dodonaea Viscosa and tested for inhibition of human neutrophil elastase (HNE), enzyme involved in inflammatory disorders. Isolated compounds were identified as a novel flavonol (1) along with eight known flavonoids (2–9). Novel flavonol, visconata (1) has a very rare skeleton having odd numbered long chain (C19) fatty acid, which was completely identified by mass fragmentation and 2D NMR analysis. All compounds (1–9) inhibited HNE in dose dependent manner with IC50s ranging between 2.4 and 150 μM. Visconata (1) emerged to be the most potent compound with 2.4 μM of IC50. In kinetic studies, compound (1) was observed to be reversible, noncompetitive inhibitor having Ki = 1.8 μM, whereas other flavonoids (2–9) displayed mixed type inhibition. 相似文献